Hostname: page-component-cb9f654ff-d5ftd Total loading time: 0 Render date: 2025-08-01T07:43:27.022Z Has data issue: false hasContentIssue false
  • English
  • Français

Experimental studies on the comparative infectivity and pathogenicity of Streptococcus suis type 2. II. Porcine and human isolates in laboratory animals

Published online by Cambridge University Press:  15 May 2009

I. D. Robertson  and
D. K. Blackmore
I. D. Robertson*
Affiliation:
Department of Veterinary Pathology and Public Health, Massey University, Palmerston North, New Zealand
D. K. Blackmore
Affiliation:
Department of Veterinary Pathology and Public Health, Massey University, Palmerston North, New Zealand
*
* Address for reprints/correspondence: I. D. Robertson, School of Veterinary Studies, Murdoch University, Perth, 6150, Western Australia.
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Mice, rats, guinea-pigs and rabbits were inoculated with isolates of Streptococcus suis type 2. An isolate cultured from the tonsils of a healthy pig, produced disease in rabbits after intravenous inoculation but not in mice, rats or guinea-pigs. An isolate of S. suis type 2, that was pathogenic for pigs and had been cultured from a human patient with clinical disease, produced signs of neurological disease in mice, rats and rabbits following intravenous inoculation. There was an apparent dose response in mice with 31 % of mice receiving more than 106 organisms developing clinical disease, whilst mice receiving less than this did not develop disease. There were no detectable histopathological lesions in the brains or meninges of mice with nervous signs. It is proposed that the disease in mice may mimic that reported in humans and that mice may be a useful indicator species for determining the virulence of isolates cultured from pigs.

Information

Type
Research Article
Information
Epidemiology & Infection , Volume 105 , Issue 3 , December 1990 , pp. 479 - 484
Copyright
Copyright © Cambridge University Press 1990

References

REFERENCES

1.Robertson, ID. Streptococcus suis type 2 - a zoonotic agent in New Zealand. N Z Med J 1986; 99: 167–8.Google Scholar
2.Keymer, IF, Heath, SE, Wood, JGP. Streptococcus suis type 2 infection in a racoon dog (Nyctereutes procyonoides) family Canidae. Vet Record 1983; 113: 624.Google Scholar
3.Hommez, J, Wullepit, J, Cassimon, P, Castryck, F, Ceyssens, K, Devriese, LA. Streptococcus suis and other streptococcal species as a cause of extramammary infection in ruminants. Vet Record 1986; 123: 626–7.Google Scholar
4.Williams, AE, Blakemore, WF, Alexander, TJL. A murine model of Streptococcus suis type 2 meningitis in the pig. Res Vet Sci 1988; 45: 394–9.CrossRefGoogle ScholarPubMed
5.Dickie, AS, Wong, PYN, North, JDK, Robertson, ID. Streptococcus suis bacteraemia. N Z Med J 1987; 100: 677.Google Scholar
6.Robertson, ID, Blackmore, DK. Experimental studies on the comparative infectivity and pathogenicity of Streptococcus suis type 2. I. Porcine and human isolates in pigs. Epidemiol Infect 1990; 105: 469–78.CrossRefGoogle ScholarPubMed
7.Chau, PY, Huang, CY, Kay, R. Streptococcus suis meningitis. An important underdiagnosed disease in Hong Kong. Med J Aust 1983; 1: 414–7.Google Scholar