Skip to main content
×
×
Home

High prevalence of Seoul hantavirus in a breeding colony of pet rats

  • L. M. McELHINNEY (a1) (a2), D. A. MARSTON (a1), K. C. POUNDER (a2), H. GOHARRIZ (a1), E. L. WISE (a1), J. VERNER-CARLSSON (a3), D. JENNINGS (a1), N. JOHNSON (a1), A. CIVELLO (a4), A. NUNEZ (a4), T. BROOKS (a2) (a5), A. C. BREED (a6) (a7), J. LAWES (a6), Å. LUNDKVIST (a3) (a8), C. A. FEATHERSTONE (a9) and A. R. FOOKS (a1) (a2)...
Summary

As part of further investigations into three linked haemorrhagic fever with renal syndrome (HFRS) cases in Wales and England, 21 rats from a breeding colony in Cherwell, and three rats from a household in Cheltenham were screened for hantavirus. Hantavirus RNA was detected in either the lungs and/or kidney of 17/21 (81%) of the Cherwell rats tested, higher than previously detected by blood testing alone (7/21, 33%), and in the kidneys of all three Cheltenham rats. The partial L gene sequences obtained from 10 of the Cherwell rats and the three Cheltenham rats were identical to each other and the previously reported UK Cherwell strain. Seoul hantavirus (SEOV) RNA was detected in the heart, kidney, lung, salivary gland and spleen (but not in the liver) of an individual rat from the Cherwell colony suspected of being the source of SEOV. Serum from 20/20 of the Cherwell rats and two associated HFRS cases had high levels of SEOV-specific antibodies (by virus neutralisation). The high prevalence of SEOV in both sites and the moderately severe disease in the pet rat owners suggest that SEOV in pet rats poses a greater public health risk than previously considered.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      High prevalence of Seoul hantavirus in a breeding colony of pet rats
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      High prevalence of Seoul hantavirus in a breeding colony of pet rats
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      High prevalence of Seoul hantavirus in a breeding colony of pet rats
      Available formats
      ×
Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Corresponding author
*Author for correspondence: Dr L. McElhinney, Animal and Plant Health Agency (APHA), Weybridge, Surrey, UK. (Email: lorraine.mcelhinney@apha.gsi.gov.uk)
Footnotes
Hide All

Deceased.

Footnotes
References
Hide All
1. Vaheri, A, et al. Hantavirus infections in Europe and their impact on public health. Reviews in Medical Virology 2013; 23: 3549.
2. Holmes, EC, Zhang, YZ. The evolution and emergence of hantaviruses. Current Opinions in Virology 2015; 10: 2733.
3. Pounder, KC, et al. Novel hantavirus in field vole, United Kingdom. Emerging Infectious Diseases 2013; 19: 673675.
4. Jameson, LJ, et al. The continued emergence of hantaviruses: isolation of a Seoul virus implicated in human disease, United Kingdom, October 2012. Eurosurveillance 2013; 18: 47.
5. Firth, C, et al. Detection of zoonotic pathogens and characterization of novel viruses carried by commensal Rattus norvegicus in New York City. MBio 2014; 5: e01933–14.
6. Pépin, M, et al. Of rats and pathogens: pathogens transmitted by urban rats with an emphasis on hantaviruses. CAB Reviews 2016; 11: 113.
7. Lin, XD, et al. Migration of Norway rats resulted in the worldwide distribution of Seoul hantavirus today. Journal of Virology 2012; 86: 972981.
8. Taori, SK, et al. UK hantavirus, renal failure, and pet rats. Lancet 2013; 381: 1070.
9. Lloyd, G, Jones, N. Infection of laboratory workers with hantavirus acquired from immunocytomas propagated in laboratory rats. Journal of Infection 1986; 12: 117125.
10. McKenna, P, et al. Serological evidence of hantavirus disease in Northern Ireland. Journal of Medical Virology 1994; 43: 3338.
11. Macé, G, et al. Severe Seoul hantavirus infection in a pregnant woman, France, October 2012. Eurosurveillance 2013; 18: 1417.
12. Jameson, LJ, et al. Pet rats as a source of hantavirus in England and Wales, 2013. Eurosurveillance 2013; 18(9). pii: 20415.
13. McElhinney, LM, et al. Hantavirus (Seoul virus) in pet rats: a zoonotic viral threat. Veterinary Record 2016; 178: 171172.
14. Lundkvist, Å, et al. Pet rat harbouring Seoul hantavirus in Sweden, June 2013. Eurosurveillance 2013; 18(27). pii: 20521.
15. Pether, JV, Lloyd, G. The clinical spectrum of human hantavirus infection in Somerset, UK. Epidemiology and Infection 1993; 111: 171175.
16. McCaughey, C, et al. Evidence of hantavirus in wild rodents in Northern Ireland. Epidemiology and Infection 1996; 117: 361365.
17. Clement, J, et al. Hantavirus infections in rodents. In: Horzinek, MC, ed. Virus Infections of Rodents and Lagomorphs, 5th Volume in a series (Osterhaus, , ed) ‘Virus infections in Vertebrates’. Amsterdam: Elsevier Science BV, 1994, pp. 295316 (ISBN 0-444-81909-6).
18. Heyman, P, et al. Serological and genetic evidence for the presence of Seoul hantavirus in Rattus norvegicus in Flanders, Belgium. Scandinavian Journal of Infectious Diseases 2009; 41: 5156.
19. Plyusnina, A, et al. Genetic characterization of Seoul hantavirus originated from Norway rats (Rattus norvegicus) captured in Belgium. Journal of Medical Virology 2012; 84: 12981303.
20. Heyman, P, et al. Seoul hantavirus in Europe: first demonstration of the virus genome in wild Raffus norvegicus captured in France. European Journal Clinical Microbiology 2004; 23: 711717.
21. Dupinay, T, et al. Detection and genetic characterization of Seoul Virus from commensal brown rats in France. Virology 2014; 11: 32.
22. Filipe, AR, et al. Hantaviral antigens and antibodies in wild rodents in Portugal. Acta Virologica 1991; 35: 287291.
23. Verner-Carlsson, J, et al. First evidence of Seoul hantavirus in the wild rat population in the Netherlands. Infection Ecology and Epidemiology 2015; 5: 27215.
24. Bennett, M, et al. Prevalence of antibody to hantavirus in some cat populations in Britain. Veterinary Record 1990; 127: 548549.
25. Dobly, A, et al. Sero-epidemiological study of the presence of hantaviruses in domestic dogs and cats from Belgium. Research in Veterinary Science 2012; 92: 221224.
26. Klempa, B, et al. Hantavirus in African wood mouse, Guinea. Emerging Infectious Diseases 2006; 12: 838840.
27. Schlegel, M, et al. Molecular identification of small mammal species using novel cytochrome B gene-derived degenerated primers. Biochemical Genetics 2012; 50: 440447.
28. Tamura, K, et al. MEGA6: molecular evolutionary genetics analysis version 6.0. Molecular Biology and Evolution 2013; 30: 27252729.
29. Felsenstein, J. Confidence-limits on phylogenies – an approach using the bootstrap. Evolution 1985; 39: 783791.
30. Lundkvist, Å, et al. Puumala and Dobrava viruses cause hemorrhagic fever with renal syndrome in Bosnia-Herzegovina: evidence of highly cross-neutralizing antibody responses in early patient sera. Journal of Medical Virology 1997; 53: 5159.
31. Glass, GE, et al. Association of intraspecific wounding with hantaviral infection in wild rats (Rattus norvegicus). Epidemiology and Infection 1988; 101: 459472.
32. Cao, S, et al. Genetic characterization of hantaviruses isolated from rodents in the port cities of Heilongjiang, China, in 2014. BMC Veterinary Research 2016; 12: 69.
33. Shi, XH, McCaughey, C, Elliott, RM. Genetic characterisation of a hantavirus isolated from a laboratory-acquired infection. Journal of Medical Virology 2003; 71: 105109.
34. Puckett, E, et al. Global population divergence and admixture of the brown rat (Rattus norvegicus). Proceedings Biological Sciences 2016; 283(1841). pii: 20161762.
35. Clement, J, Maes, P, Ranst, MV. Hemorrhagic fever with renal syndrome in the new, and hantavirus pulmonary syndrome in the old world: paradi(se)gm lost or regained?. Virus Research 2014; 187: 5558.
36. Barthold, SW, et al. Pathology of Laboratory Rodents and Rabbits, 4th edn. Ames, USA: John Wiley & Sons, Inc., 2016.
37. Rothenburger, JL, et al. Respiratory pathology and pathogens in wild urban rats (Rattus norvegicus and Rattus rattus). Veterinary Pathology 2015; 52: 12101219.
38. Plyusnina, IZ, Solov'eva, MY, Oskina, IN. Effect of domestication on aggression in gray Norway rats. Behavior Genetics 2011; 41: 583592.
39. Ruan, C, Zhang, Z. Laboratory domestication changed the expression patterns of oxytocin and vasopressin in brains of rats and mice. Anatomical Science International 2016; 91: 358370.
40. Hinson, ER, et al. Wounding: the primary mode of Seoul virus transmission among male Norway rats. American Journal of Tropical Medicine and Hygiene 2004; 70(3): 310317.
41. Lundkvist, A, Horling, J, Niklasson, B. The humoral response to Puumala virus infection (nephropathia epidemica) investigated by viral protein specific immunoassays. Archives of Virology 1993; 130: 121130.
42. Manigold, T, et al. Highly differentiated, resting gn-specific memory CD8+ T cells persist years after infection by Andes hantavirus. PLoS Pathogens 2010; 6: 1000779.
43. Vapalahti, O, et al. Isolation and characterization of a hantavirus from Lemmus sibiricus: evidence for host-switch during hantavirus evolution. Journal of Virology 1999; 73: 55865592.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Type Description Title
WORD
Supplementary materials

McElhinney et al supplementary material 1
McElhinney et al supplementary material

 Word (181 KB)
181 KB

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed