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A hospital-based matched case–control study to identify risk factors for clinical infection with OXA-48-producing Klebsiella pneumoniae in rectal carriers

  • A. MADUEÑO (a1), J. GONZALEZ GARCIA (a2), A. AGUIRRE-JAIME (a3) and M. LECUONA (a1) (a4)

Summary

Asymptomatic colonisation of the gastrointestinal tract by carbapenemase-producing Enterobacteriaceae is an important reservoir for transmission, which may precede infection. This retrospective observational case–control study was designed to identify risk factors for developing clinical infection with OXA-48-producing Klebsiella pneumoniae in rectal carriers during hospitalisation. Case patients (n = 76) had carbapenemase-producing K. pneumoniae (CPKP) infection and positive rectal culture for CPKP. Control patients (n = 174) were those with rectal colonisation with CPKP but without CPKP infection. Multivariate analysis identified the presence of a central venous catheter (OR 4·38; 95% CI 2·27–8·42; P = 0·008), the number of transfers between hospital units (OR 1·27; 95% CI (1·06–1·52); P < 0·001) and time at risk (OR 1·02 95% CI 1·01–1·03; P = 0·01) as independent risk factors for CPKP infection in rectal carriers. Awareness of these risk factors may help to identify patients at higher risk of developing CPKP infection.

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Copyright

Corresponding author

*Author for correspondence: A. Madueño, Hospital Universitario de Canarias, Ofra s/n 38 320 La Laguna, Santa Cruz de Tenerife, Spain. (Email: ana_madueno@hotmail.com)

References

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