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IL-8/IL-17 gene variations and the susceptibility to severe viral bronchiolitis

  • L. A. PINTO (a1) (a2), L. A. DE AZEREDO LEITÃO (a1) (a2), M. MOCELLIN (a1) (a2), P. ACOSTA (a1) (a3), M. T. CABALLERO (a1) (a3), R. LIBSTER (a1) (a3), J. E. VARGAS (a1) (a2), F. POLACK (a1) (a3), T. COMARU (a1) (a2), R. T. STEIN (a1) (a2) and A. P. DE SOUZA (a1) (a2)...

Clinical manifestations of acute bronchiolitis (AB) vary from minimal disease to severe respiratory failure. The response to respiratory viral infections is possibly influenced by genetic polymorphisms linked to the regulation of the inflammatory response. In the present study, we investigated whether interleukin-8 (IL-8) and interleukin-17 (IL-17) genetic variants are associated with the severity of AB. A group of Brazilian infants hospitalized with AB and a control group (infants with no or mild AB, without hospitalization) were genotyped for four IL-8/IL-17 variations. For replication, we studied an Argentinean population sample of infants with mild and severe AB. IL-8 polymorphism (rs 2227543) and IL-17 (rs2275913) variants showed significant associations with the severity of AB. The effect of the IL-8 variation could be replicated in the Argentinean sample. This finding suggests that IL-8 variations may influence the severity of AB in young infants. Further genetic association studies in low- or middle-income populations are necessary with the aim of expanding knowledge in this area.

Corresponding author
*Author for correspondence: Dr L. A. Pinto, Avenida Ipiranga, 6690, 2° andar, Instituto de Pesquisas Biomédicas. CEP 90·610-000, Porto Alegre, RS, Brasil. (Email:
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1. Mallol, J, et al. International prevalence of recurrent wheezing during the first year of life: variability, treatment patterns and use of health resources. Thorax 2010; 65: 10041009.
2. Ciencewicki, JM, et al. A genetic model of differential susceptibility to human respiratory syncytial virus (RSV) infection. Journal of the Federation of American Societies for Experimental Biology 2014; 28: 19471956.
3. Hull, J, Thomson, A, Kwiatkowski, D. Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families. Thorax 2000; 55: 10231027.
4. Faber, TE, et al. Specific increase in local IL-17 production during recovery from primary RSV bronchiolitis. Journal of Medical Virology 2012; 84: 10841088.
5. Heinzmann, A, et al. Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. Journal of Allergy and Clinical Immunology 2004; 114: 671676.
6. Hacking, D, et al. Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility. Genes and Immunity 2004; 5: 274282.
7. Beigelman, A, et al. Randomized trial to evaluate azithromycin's effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis. Journal of Allergy and Clinical Immunology 2015; 135: 11711178.
8. Pinto, LA, et al. Azithromycin therapy in hospitalized infants with acute bronchiolitis is not associated with better clinical outcomes: a randomized, double-blinded, and placebo-controlled clinical trial. Journal of Pediatrics 2012; 161: 11041108.
9. Pinto, LA, et al. Polymorphisms in the IRF-4 gene, asthma and recurrent bronchitis in children. Clinical and Experimental Allergy 2013; 43: 11521159.
10. Caballero, MT, et al. TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization. Journal of Clinical Investigation 2015; 125: 571582.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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