Hostname: page-component-7c8c6479df-ph5wq Total loading time: 0 Render date: 2024-03-28T19:34:05.224Z Has data issue: false hasContentIssue false

The impact of physico-chemical stress on the toxigenicity of Vibrio cholerae

Published online by Cambridge University Press:  19 October 2009

Christopher J. Miller
Affiliation:
Department of Tropical Hygiene, London School of Hygiene and Tropical Medicine
Bohumil S. Drasar
Affiliation:
Department of Medical Microbiology, London School of Hygiene and Tropical Medicine
Richard G. Feachem
Affiliation:
Department of Tropical Hygiene, London School of Hygiene and Tropical Medicine
Richard J. Hayes
Affiliation:
Tropical Epidemiology Unit, London School of Hygiene and Tropical Medicine
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The expression of toxigenicity by Vibrio cholerae, before and after exposure to various conditions of salinity, pH and cation composition and concentration, has been measured. Exposure to these conditions did not select for hyper- or hypo-toxigenic strains. This suggests that toxigenic V. cholerae O 1 are unlikely to lose their toxigenicity when exposed to environmental stress and that V. cholerae toxin production is not a response to the stresses included in this study. These results are consistent with an aquatic reservoir for toxigenic V. cholerae O 1.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1986

References

REFERENCES

Craig, J. P., Yamamoto, K., Takeda, Y. & Miwatani, T. (1981). Production of a cholera like enterotoxin by a Vibrio cholerae non O 1 strain isolated from the environment. Infection and Immunity 34, 9097.CrossRefGoogle Scholar
Finkelstein, R. A., Atthasampunna, P., Chulasamaya, M. & Charunmethee, P. (1966). Pathogenesis of experimental cholera: biologic activities of purified procholeragen A. Journal of Immunology 96, 440449.CrossRefGoogle Scholar
Giugliano, L. G., Mann, G. F. & Drasar, B. S. (1982). Response of mammalian cell lines to the toxins of Eacherichia coli. Journal of Medical Microbiology 15, 531539.CrossRefGoogle Scholar
Jiwa, S. F. H., Krovaoek, K. & Wadstrom, T. (1981). Enterotoxigenic bacteria in food and water from an Ethiopian community. Applied and Environmental Microbiology 41, 10101019.CrossRefGoogle ScholarPubMed
Miller, C. J., Drasar, B. S. & Feachem, R. G. (1984). Response of toxigenic Vibrio cholerae O 1 to physico-chemical stresses in aquatic environments. Journal of Hygiene 93, 475496.CrossRefGoogle Scholar
Miller, C. J., Feachem, R. G. & Drasar, B. S. (1985). Cholera epidemiology in developed and developing countries: new thoughts on transmission, seasonality and control. Lancet i, 261263.CrossRefGoogle Scholar
Sack, D., Huda, S., Neogi, P., Daniel, R. & Spira, W. (1980). Microtitre ganglioside enzyme-linked immunosorbent assay for Vibrio and Escherichia coli heat labile enterotoxins and antitoxin. Journal of Clinical Microbiology 11, 3540.CrossRefGoogle ScholarPubMed
Sanyal, S. C., Alam, K., Neogi, P. K. B., Huq, M. I. & Al-Mahmud, K. A. (1983). A new cholera toxin. Lancet i, 1337.CrossRefGoogle Scholar