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Induction of immunological memory in UK infants by a meningococcal A/C conjugate vaccine

  • R. BORROW (a1), A. J. FOX (a1), P. C. RICHMOND (a2), S. CLARK (a1), F. SADLER (a1), J. FINDLOW (a1), R. MORRIS (a3), N. T. BEGG (a2) and K. A. V. CARTWRIGHT (a3)...

Abstract

The induction of immunological memory to serogroup A and C polysaccharides in UK infants immunized with three doses of a meningococcal A/C oligosaccharide CRM197 conjugate vaccine was investigated. Forty UK infants vaccinated previously with three doses of a meningococcal A/C oligosaccharide-CRM197 conjugate vaccine at 2, 3 and 4 months of age, were revaccinated at a mean age of 145·6 weeks with either a 10 or 50 μg dose of licensed meningococcal A/C polysaccharide vaccine. Serogroup-specific antibody and serum bactericidal antibody (SBA) responses were measured by enzyme-linked immunosorbent assay and serum bactericidal assays, respectively. Following challenge, anti-serogroup A and C polysaccharide antibody levels rose from pre-booster geometric mean concentrations (GMC) of 3·1 and 2·1 μg/ml respectively to 19·6 and 21·0 μg/ml 1 month post-booster. Serum bactericidal antibody geometric mean titres (GMTs) for serogroups A and C increased 156- and 113-fold from 2·1 and 7·1 pre-booster respectively to 327·4 and 800·7 post-booster. A serogroup A control group of 45 children received a 10 μg dose of licensed meningococcal A/C polysaccharide vaccine (with no prior history of serogroup A vaccination) had serogroup A SBA GMTs of 2·3 pre- vaccination rising to 8 post-vaccination with corresponding GMCs of 0·8 and 10·8 μg/ml. These rises in SBA following serogroup A/C conjugate vaccination are indicative of immunological priming.

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