Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-23T06:41:21.182Z Has data issue: false hasContentIssue false
  • English
  • Français

Isolation of variants during passage of a strain of foot-and-mouth disease virus in partly immunized cattle

Published online by Cambridge University Press:  15 May 2009

N. St G. Hyslop  and
R. H. Fagg
N. St G. Hyslop
Affiliation:
The Animal Virus Research Institute, Pirbright, Woking, Surrey
R. H. Fagg
Affiliation:
The Animal Virus Research Institute, Pirbright, Woking, Surrey
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Foot-and-mouth disease virus of Type SAT 1 (strain Turkey 323/62) was passaged serially 34 times in cattle previously vaccinated with increasing doses of formol-treated vaccine of the homologous strain. Primary vesicles developed in all the partly immunized animals and secondary lesions occurred in the majority. Virus from the 34th passage was capable of reinfecting a steer only 76 days after primary infection early in the passage series. Virus isolated from the second infection of this animal differed from that isolated from the primary infection in complement-fixing properties and in sensitivity to antiserum, and these differences were of a degree indicative of subtype variation.

The variant strain was transmissible by contact, and virus titres in tongue and foot lesions of partly immunized animals were of the same order as those encountered in susceptible cattle.

These observations suggest one way in which variant strains may arise in the field.

Type
Research Article
Information
Journal of Hygiene , Volume 63 , Issue 3 , September 1965 , pp. 357 - 368
Copyright
Copyright © Cambridge University Press 1965

References

Bradish, C. J. & Brooksby, J. B. (1960). Complement fixation studies of the specificity of the interactions between components of the virus system of foot-and-mouth disease and its antibodies. J. gen. Microbiol. 22, 405.CrossRefGoogle ScholarPubMed
Beadish, C. J., Brooksby, J. B. & Tsubahara, H. (1960). The complement fixation test in studies of components of the virus system of foot-and-mouth disease and its antibodies. J. gen. Microbiol. 22, 392.CrossRefGoogle Scholar
Brooksby, J. B. (1952). The technique of complement fixation in foot-and-mouth disease research. A.R.G. Rep. Ser. no. 12.Google Scholar
Frenkel, H. S. (1949). Histologic changes in explanted bovine epithelial tongue tissue infected with the virus of foot-and-mouth disease. Am. J. vet. Res. 10, 142.Google ScholarPubMed
Frenkel, H. S. (1951). Research on foot-and-mouth disease. III. The cultivation of virus on a practical scale. Am. J. vet. Res. 12, 187.Google ScholarPubMed
Frenkel, H. S. (1953). Recherches sur la fièvre aphteuse. IV. Bull. Off. int. Éipizoot. 39, 91.Google Scholar
Hyslop, N. St G., Davie, J. & Carter, S. P. (1963). Antigenic differences between strains of foot-and-mouth disease virus of type SAT 1. J. Hyg., Camb., 61, 217.CrossRefGoogle ScholarPubMed
Kärber, G. (1931). Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche. Arch. exp. Path. Pharmah. 162, 480.CrossRefGoogle Scholar
Martin, W. B. & Chapman, W. G. (1961). The tissue culture colour test for assaying the virus and neutralizing antibody of foot-and-mouth disease and its application to the measurement of immunity in cattle. Res. vet. Sci. 2, 53.CrossRefGoogle Scholar
Skinner, H. H. (1951). Propagation of strains of foot-and-mouth disease virus in unweaned white mice. Proc. R. Soc. Med. 44, 1041.Google ScholarPubMed