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Listeria monocytogenes meningitis: serotype distribution and patient characteristics in The Netherlands, 1976–95

Published online by Cambridge University Press:  18 July 2002

Y. AOUAJ ,
L. SPANJAARD ,
N. VAN LEEUWEN  and
J. DANKERT
Y. AOUAJ
Affiliation:
Netherlands Reference Laboratory for Bacterial Meningitis of the Academic Medical Center (AMC) and the National Institute of Public Health and the Environment (RIVM), Academic Medical Center, Amsterdam
L. SPANJAARD
Affiliation:
Netherlands Reference Laboratory for Bacterial Meningitis of the Academic Medical Center (AMC) and the National Institute of Public Health and the Environment (RIVM), Academic Medical Center, Amsterdam
N. VAN LEEUWEN
Affiliation:
The National Institute of Public Health and the Environment, Bilthoven, The Netherlands
J. DANKERT
Affiliation:
Netherlands Reference Laboratory for Bacterial Meningitis of the Academic Medical Center (AMC) and the National Institute of Public Health and the Environment (RIVM), Academic Medical Center, Amsterdam
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Abstract

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Two hundred and seven cases of listeria meningitis that occurred in The Netherlands over 20 years were reviewed to study associations between Listeria monocytogenes serotype, age, underlying disease, and outcome. The mean annual incidence per 100000 population was 0·12 in 1981–90, decreasing to 0·07 in 1991–5. Underlying disease was present in 50% of non-neonatal patients, most often haematological malignancy (15%) and the use of immunosuppressive therapy (14%). The meningitis-related case fatality rate was 16%; a significantly higher rate was associated with the presence of underlying disease (30%) or age [ges ]70 years (29%). Serotype 4b was most frequent (65%) and L. monocytogenes types 1/2a, 1/2b, or 1/2c (30% of cases) were significantly more often isolated from non-neonatal patients with underlying disease, suggesting a higher virulence of listerial serotype 4b.

Type
Research Article
Information
Epidemiology & Infection , Volume 128 , Issue 3 , June 2002 , pp. 405 - 409
Copyright
2002 Cambridge University Press