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Marked decrease in the incidence and prevalence of hepatitis A in the Basque Country, Spain, 1986–2004

  • G. CILLA (a1), E. PÉREZ-TRALLERO (a1) (a2), J. ARTIEDA (a3), E. SERRANO-BENGOECHEA (a1), M. MONTES (a1) and D. VICENTE (a1)
  • DOI:
  • Published online: 20 July 2006

The aim of this study was to determine changes in the epidemiology of hepatitis A virus (HAV) infection in the Basque Country, Spain, and to evaluate their implications for vaccination strategies. A total of 1356 persons were enrolled in a study of the prevalence of anti-HAV in 2004 and compared with two previous studies (1986–1987 and 1992). The selection method and the characteristics of the population were similar in the three studies. A marked decline in the seroprevalence in all age groups (P<0·001) and in the incidence of cases/100000 inhabitants (from 38·0 in 1986–1988 to 2·9 in 2002–2004) were observed. The mean age of patients with hepatitis A increased from 17·7 years in 1986–1992 to 21·2 years in 1993–1998 and 25·3 years in 1999–2004 (P<0·001). Between 1997 and 2004, 20% of patients were hospitalized. The changes observed have occurred rapidly causing a change in the epidemiological pattern from middle-high endemicity (1986) to low endemicity (2004).

Corresponding author
Servicio de Microbiología, Hospital Donostia, Paseo Dr. Beguiristain s/n, 20014 San Sebastián, Spain. (Email:
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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