Hostname: page-component-7dd5485656-j7khd Total loading time: 0 Render date: 2025-10-30T19:18:20.639Z Has data issue: false hasContentIssue false
  • English
  • Français

A model based evaluation of the 1996–7 pertussis epidemic in the Netherlands

Published online by Cambridge University Press:  28 August 2001

M. VAN BOVEN ,
H. E. DE MELKER ,
J. F. P. SCHELLEKENS  and
M. KRETZSCHMAR
M. VAN BOVEN
Affiliation:
Department of Infectious Diseases Epidemiology, National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
H. E. DE MELKER
Affiliation:
Department of Infectious Diseases Epidemiology, National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
J. F. P. SCHELLEKENS
Affiliation:
Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
M. KRETZSCHMAR
Affiliation:
Department of Infectious Diseases Epidemiology, National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

In the Netherlands a strong epidemic outbreak of pertussis took place in 1996–7. Here we investigate the possible causes of the epidemic, using an age-structured epidemic model. Motivated by the observation that during the epidemic the number of cases in vaccinated children had increased considerably compared to the preceding period, we focus on two vaccination related changes. First, we consider the possibility that the potency of the vaccine decreased so that it confers protection for a shorter period of time in newly vaccinated children. Second, we consider the possibility that at a certain point in time the duration of protection after vaccination decreased for all individuals. This may be the case if the pathogen population changed such that the current vaccine confers less protection. A comparison of the observed and simulated age-distribution of infections indicates that the second scenario is more in line with the observed pattern of the 1996–7 epidemic. We discuss the implications of this conclusion for B. pertussis circulation, and for the design of vaccination programmes in the face of a polymorphic B. pertussis population that may adapt itself to vaccination.

Information

Type
Research Article
Information
Epidemiology & Infection , Volume 127 , Issue 1 , August 2001 , pp. 73 - 85
Copyright
2001 Cambridge University Press