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Modelling Ebola within a community

  • R. N. LEANDER (a1), W. S. GOFF (a1), C. W. MURPHY (a1) and S. A. PULIDO (a1)
Summary

The 2014 Ebola epidemic was the largest on record. It evidenced the need for improved models of the spread of Ebola. In this research we focus on modelling Ebola within a small village or community. Specifically, we investigate the potential of basic Susceptible-Exposed-Infectious-Recovered (SEIR) models to describe the initial Ebola outbreak, which occurred in Meliandou, Guinea. Data from the World Health Organization is used to compare the accuracy of various models in order to select the most accurate models of transmission and disease-induced responses. Our results suggest that (i) density-dependent transmission and mortality-induced behavioural changes shaped the course of the Ebola epidemic in Meliandou, while (ii) frequency-dependent transmission, disease-induced emigration, and infection-induced behavioural changes are not consistent with the data from this epidemic.

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Corresponding author
*Author for correspondence: Professor R. N. Leander, Department of Mathematical Sciences, Middle Tennessee State University, Murfreesboro, TN 37132, USA. (Email: rachel.leander@mtsu.edu)
References
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1. World Health Organization Ebola Response Team. Ebola virus disease in West Africa: the first 9 months of the epidemic and forward projections. New England Journal of Medicine 2014; 371: 14811495.
2. World Health Organization. Ground zero in Guinea: the outbreak smoulders undetected for more than 3 months (http://www.who.int/csr/disease/ebola/ebola-6-months/guinea/en/). Accessed 16 March 2015.
3. Rivers, C, et al. Modeling the impact of interventions on an epidemic of Ebola in Sierra Leone and Liberia. PLOS Currents Outbreaks. Published online: 16 October 2014. doi:10.1371/currents.outbreaks.fd38dd85078565450b0be3fcd78f5ccf.
4. Metzler, M, et al. Estimating the future number of cases in the ebola epidemic – Liberia and Sierra Leone, 2014–2015. 2014. Morbidity and Mortality Weekly Report 2014; 63: 114.
5. Center for Disease Control (CDC). 2014 Ebola outbreak in West Africa – case counts (http://www.cdc.gov/vhf/ebola/outbreaks/2014-west-africa/case-counts.html). Accessed 20 February 2015.
6. Keeling, M, Rohani, P. Modeling Infectious Diseases in Humans and Animals, 1st edn. Princeton, New Jersey: Princeton University Press, 2008, pp. 17.
7. United Nations, Department of Economic and Social Affairs, Population Division. Annex table. Data for 12 indicators, by country. In: Charting the Progress of Populations. New York, NY, USA, 2000; ST/ESA/SER.R/151.
8. Faul, M. The village of Meliandou: Guinea's ground zero for the Ebola virus. Vatican Radio. Published online: 12 October 2014 (http://en.radiovaticana.va/news/2014/12/10/the_village_of_meliandou_guineas_ground_zero_ebola_/1114310). Accessed 20 June 2015.
9. Copernicus: The European Earth observation programme. Meliandou-Guinea Other. 1 March 2014. Reference Map. Detail (http://emergency.copernicus.eu/mapping/system/files/components/EMSR076_01MELIANDOU_REFERENCE_DETAIL01_v2_300dpi.pdf). Accessed 20 June 2015.
10. World Health Organization (WHO). Origins of the 2014 Ebola epidemic: one year into the Ebola epidemic. January 2015 (http://www.who.int/csr/disease/ebola/one-year-report/virus-origin/en/).
11. Beukes, S. Finding Ebola's patient zero. Daily Maverick. Published online: 28 October 2014 (http://www.theguardian.com/world/2014/oct/28/ebola-virus-guinea-first-victim-patient-zero). Accessed 16 March 2015.
12. McCallum, H, Barlow, N, Hone, J. How should pathogen transmission be modeled? Trends in Ecology and Evolution 2001; 16: 295300.
13. The World Bank. Population, total (http://data.worldbank.org/indicator/SP.POP.TOTL). Accessed 5 February 2016.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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