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Nasal mucus and influenza viruses. I. The haemagglutinin inhibitor in nasal secretions

Published online by Cambridge University Press:  15 May 2009

S. Fazekas De St Groth
S. Fazekas De St Groth
Affiliation:
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
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A technique is developed by which minimal changes in haemagglutinin inhibitors can be detected.

It is shown that the inhibitor index of normal human nasal secretions is 33·2 with a standard deviation of ±7·4. This value is independent of the donor, of the absolute amount of mucus collected, of the time of extraction, and of the period of storage.

Minimal amounts of influenza viruses (less than one agglutinating dose) are capable of causing significant alteration in the inhibitor index upon interaction in vitro for 60 min. at 37° C.

Type
Research Article
Information
Journal of Hygiene , Volume 50 , Issue 4 , December 1952 , pp. 471 - 490
Copyright
Copyright © Cambridge University Press 1952

References

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