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A norovirus oyster-related outbreak in a nursing home in France, January 2012

  • P. LOURY (a1), F. S. LE GUYADER (a2), J. C. LE SAUX (a2), K. AMBERT-BALAY (a3), P. PARROT (a4) and B. HUBERT (a1)...
Summary

The presence of norovirus in shellfish is a public health concern in Europe. Here, we report the results of an investigation into a norovirus gastroenteritis outbreak following a festive lunch which affected 84 (57%) residents and staff members of a nursing home in January 2012 in France. Individuals who had eaten oysters had a significantly higher risk of developing symptoms in the following 2·5 days than those who had not, the risk increasing with the amount eaten [relative risk 2·2 (1·0–4·6) and 3·3 (1·6–6·6) for 3–4 and 5–12 oysters, respectively]. In healthy individuals during those days, 29 (32%) subsequently became ill, most of whom were staff members performing activities in close contact with residents. Genogroup II noroviruses were detected in faecal samples, in a sample of uneaten oysters and in oysters from the production area. Identifying a norovirus's infectious dose may facilitate the health-related management of contaminated shellfish.

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Corresponding author
* Author for correspondence: Miss P. Loury, InVS-Cire Pays de la Loire, ARS des Pays de la Loire, 17 boulevard Gaston Doumergue, CS 56 233, 44 262 Nantes, Cedex 2, France. (Email: pascaline.loury@ars.sante.fr)
References
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1. Van Beek, J, et al. Indications for worldwide increased norovirus activity associated with emergence of a new variant of genotype II.4, late 2012. Eurosurveillance 2013; 18: 89.
2. Glass, RI, Parashar, UD, Estes, MK. Norovirus gastroenteritis. New England Journal of Medicine 2009; 361: 17761785.
3. Le Guyader, FS, Atmar, RL, Le Pendu, J. Transmission of viruses through shellfish: when specific ligands come into play. Current Opinion in Virology 2012; 2: 103110.
4. European Food Safety Authority Panel on Biological Hazards. Scientific opinion on norovirus in oysters: methods, limits and control options. European Food Safety Authority Journal 2012; 10(1), 2500 (39 pp).
5. Teunis, PF, et al. Norwalk virus: how infectious is it? Journal of Medical Virology 2008; 80: 14681476.
6. Thebault, A, et al. Infectivity of GI and GII noroviruses established from oyster related outbreaks. Epidemics 2013; 5: 98110.
7. Heymann, DL. Control of Communicable Diseases Manual, 18th edn. Washington: APHA, 2004.
8. Gotz, H, et al. Clinical spectrum and transmission characteristics of infection with Norwalk-like virus: findings from a large community outbreak in Sweden. Clinical Infectious Diseases 2001; 33: 622628.
9. Lyman, WH, et al. Prospective study of etiologic agents of acute gastroenteritis outbreaks in child care centers. Journal of Pediatrics 2009; 154: 253257.
10. Da Silva, AK, et al. Evaluation of removal of noroviruses during wastewater treatment, using real-time reverse transcription-PCR: different behaviors of genogroups I and II. Applied and Environmental Microbiology 2007; 73: 78917897.
11. Sdiri-Loulizi, K, et al. Acute infantile gastroenteritis associated with human enteric viruses in Tunisia. Journal of Clinical Microbiology 2008; 46: 13491355.
12. Chapman, NM, et al. Molecular detection and identification of enteroviruses using enzymatic amplification and nucleic acid hybridization. Journal of Clinical Microbiology 1990; 28: 843850.
13. Robertson, BH, Brown, VK, Khanna, B. Altered hepatitis A VP1 protein resulting from cell culture propagation of virus. Journal of Virology 1989; 13: 207212.
14. Le Guyader, FS, et al. Comprehensive analysis of a norovirus-associated gastroenteritis outbreak, from the environment to the consumer. Journal of Clinical Microbiology 2010; 48: 915920.
15. Sima, LC, et al. Calicivirus removal in a membrane bioreactor wastewater treatment plant. Applied and Environmental Microbiology 2011; 77: 51705177.
16. Le Guyader, FS, et al. Detection of multiple noroviruses associated with an international gastroenteritis outbreak linked to oyster consumption. Journal of Clinical Microbiology 2006; 44: 38783882.
17. Le Guyader, FS, et al. Aichi virus, norovirus, astrovirus, enterovirus, and rotavirus involved in clinical cases from a French oyster-related gastroenteritis outbreak. Journal of Clinical Microbiology 2008; 46: 40114017.
18. Guillois-Becel, Y, et al. Investigation of two foodborne disease outbreaks linked to shellfish consumption in the Loire-Atlantique district, France, 2010 [in French]. Bulletin Epidémiologique Hebdomadaire 2010; 37: 390392.
19. Schaeffer, J, et al. Norovirus contamination on French marketed oysters. International Journal of Food Microbiology 2013; 166: 244248.
20. Richards, GP, McLeod, C, Le Guyader, FS. Processing strategies to inactivate enteric viruses in shellfish. Food Environmental Virology 2010. Report No.: 2.
21. Kaplan, JE, et al. An outbreak of acute nonbacterial gastroenteritis in a nursing home. Demonstration of person-to-person transmission by temporal clustering of cases. American Journal of Epidemiology 1982; 116: 940948.
22. French Agency for Food Environmental and Occupational Health and Safety (Anses). Opinion on a risk assessment relating to the reopening of a shellfish growing area closed due to the presence of calicivirus (norovirus and sapovirus) in live shellfish. Maison-Alfort, France: Anses, February 2011.
23. Sukhrie, FH, et al. Nosocomial transmission of norovirus is mainly caused by symptomatic cases. Clinical Infectious Diseases 2012; 54: 931937.
24. Hutson, AM, et al. Norwalk virus infection and disease is associated with ABO histo-blood group type. Journal of Infectious Diseases 2002; 185: 13351337.
25. Larsson, MM, et al. Antibody prevalence and titer to norovirus (genogroup II) correlate with secretor (FUT2) but not with ABO phenotype or Lewis (FUT3) genotype. Journal of Infectious Diseases 2006; 194: 14221427.
26. Nordgren, J, et al. Norovirus gastroenteritis outbreak with a secretor-independent susceptibility pattern, Sweden. Emerging Infectious Diseases 2010; 16: 425434.
27. Le Pendu, J, et al. Mendelian resistance to human norovirus infections. Seminars in Immunology 2006; 18: 375386.
28. Atmar, RL, et al. Norwalk virus shedding after experimental human infection. Emerging Infectious Diseases 2008; 14: 15531557.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
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