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On the Supersensitation of Persons suffering from Diphtheria by Repeated Injections of Horse Serum

Published online by Cambridge University Press:  15 May 2009

J. R. Currie
J. R. Currie
Affiliation:
Senior Assistant Physician, Belvidere Fever Hospital, Glasgow.
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When the blood serum of one animal is injected into an animal of a different species the injected animal in many instances appears to take no hurt. If however after a certain interval the experiment is repeated, it has been noted that the injected animal may speedily show evidence of physical disturbance. Its breathing becomes rapid: its heart-beat grows feeble: its limbs move spasmodically and general convulsions may ensue. These phenomena have been taken to indicate that the injected animal has been supersensitized—or rendered abnormally sensitive—to the serum employed. They may attain such gravity that the animal dies. It has been suggested that the same untoward issue is possible in the case of man, and that the death of patients under treatment for diphtheria is to be apprehended in certain circumstances as the result of repeated injections of antidiphtherial serum, for the reason that the serum in question is derived not from the human subject but from the horse. A suggestion which assails the prestige of the antitoxin treatment of diphtheria cannot be viewed with indifference: it must either be sustained or rejected.

Type
Research Article
Information
Journal of Hygiene , Volume 7 , Issue 1 , January 1907 , pp. 35 - 60
Copyright
Copyright © Cambridge University Press 1907

References

REFERENCES

Anderson, (ix. 1906). Simultaneous transmission of resistance to diphtheria toxin and hypersusceptibility to horse serum by the female guinea-pig to her young. Journ. Med. Research, Boston, Mass., Vol. xv. p. 259.Google Scholar
Arthus, (26. vi. 1903). Injections répétées de sérum de cheval chez le lapin. C. R. Soc. de Biol., T. 55, p. 817.Google Scholar
Arthus, and Breton, (27. xi. 1903). Lésions cutanées produites par les injections de sérum de cheval chez le lapin anaphylactisé par et pour ce sérum. C. R. Soc. de Biol., T. 55, p. 1478.Google Scholar
Battelli, (17. iii. 1905). L'anaphylaxie vis-à-vis des globules sanguins chez les animaux immunisés. C. R. Soc. de Biol., T. 58, p. 450.Google Scholar
von Behring, and Kitashima, (11. ii. 1901). Ueber Verminderung und Steigerung der ererbten Giftempfindlichkeit. Berlin. klin. Wochenschr., pp. 157, 162.Google Scholar
Brieger, . Cited by Otto, p. 9.Google Scholar
Brownlee, (7. xi. 1906). Statistical studies in immunity: the incubation period and the crisis. Trans. Royal Philos. Soc. Glasgow, 1906–1907.Google Scholar
von Dungern, (1903). Die Antikörper. Gustav Fischer, Jena, pp. 87, 88 and 109.Google Scholar
Ehrlich, . Cited by von Pirquet Schick, 1906, p. 68.Google Scholar
Kretz, . Cited by Wassermann in Kolle Wassermann's Handbuch der pathogenen Mikroorganismen 1904. Band iv. Teil i. p. 478.Google Scholar
Löventhal, . Cited by Wladimiroff in Kolle Wassermann's Handbuch der pathogenen Mikroorganismen, Bd. iv. Teil ii. p. 1138.Google Scholar
Nocard, Les Tuberculoses animales. Paris, G. Masson, p. 76.Google Scholar
Otto, . Das Theobald Smithsche Phänomen der Serum-Ueberempfindlichkeit. v. Leuthold Gedenkschrift, Bd. i. pp. 9, 16, 18. (Reprint.)Google Scholar
von Pirquet, and Schick, (1905). Die Serumkrankheit. Franz Deuticke, Leipzig und Wien, pp. 84, 89, 98.Google Scholar
von Pirquet, and Schick, (9. i. 1906). Ueberempfindlichkeit und beschleunigte Reaktion. Münch. med. Wochenschrift. Jg. 53, p. 67.Google Scholar
Rist, (17. vii. 1903). Sur la toxicité des corps des Bacilles Diphtériques. C. R. Soc. de Biol. T. 55, p. 978.Google Scholar
Rolleston, (v. 1905). Some aspects of the serum treatment of diphtheria. Practitioner, Vol. lxxiv. p. 664.Google Scholar
Rosenau, and Anderson, (vii. 1906). A new toxic action of horse serum. Journ. of Med. Research, Boston, Mass., Vol. xv. pp. 179, 193.Google Scholar
Vallée., Apropósito de la tolerancia de la tuberculina por los animales tuberculosos. Boletin del Instituto de Alfonso XIII, 1905, año i. No. 3, p. 161. From Rev. Gén. de Méd. Vétér. Num. 40. Also, A propósito de la reaccion a la tuberculina. The same, año i. No. 3, p. 165. From the same, 15 March, 1905.Google Scholar
Wolff, (1904). Ueber Grundgesetze der Immunität. Centralbl. f. Bakteriol. Originale, Bd. 37, p. 687.Google Scholar
Wright, (9. v. 1903). On Therapeutic Inoculations of Bacterial Vaccines. Brit. Med. Journ. Vol. i. p. 1069.CrossRefGoogle Scholar
Zucker, (2. xi. 1905). Ueber den Effekt des Diphtherieheilserums bei widerholter Erkrankung und Injektion. Wien. klin. Wochenschr. Jg. 18, p. 1150.Google Scholar