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Optimum moving averages for the estimation of median effective dose in bioassay

Published online by Cambridge University Press:  15 May 2009

B. M. Bennett
B. M. Bennett
Affiliation:
University of Washington, Seattle
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Optimum forms of moving averages are derived for the estimation of LD 50 in the situation where no assumptions are made about the form of the dose-response distribution. The theory is also applied to uses of moving averages based on the angular transformation of the percentage response. A numerical example illustrates this application, and its results are compared with the corresponding probit and logit estimates.

Type
Research Article
Information
Journal of Hygiene , Volume 61 , Issue 4 , December 1963 , pp. 401 - 406
Copyright
Copyright © Cambridge University Press 1963

References

Bennett, B. M. (1952). Estimation of LD 50 by moving averages. J. Hyg., Camb., 50, 157–64.CrossRefGoogle ScholarPubMed
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Thompson, W. R. (1947). Use of moving averages and interpolation to estimate median-effective dose. Bact. Rev. 11, 115–45.CrossRefGoogle ScholarPubMed