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Epidemiology & Infection Epidemiology & Infection

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Pandemic (H1N1) 2009 influenza in the UK: clinical and epidemiological findings from the first few hundred (FF100) cases

Published online by Cambridge University Press:  01 July 2010

E. McLEAN ,
R. G. PEBODY ,
C. CAMPBELL ,
M. CHAMBERLAND ,
C. HAWKINS ,
J. S. NGUYEN-VAN-TAM ,
I. OLIVER ,
G. E. SMITH ,
C. IHEKWEAZU  and
S. BRACEBRIDGE
...Show all authors
E. McLEAN
Affiliation:
Health Protection Agency, Centre for Infections, London, UK
R. G. PEBODY*
Affiliation:
Health Protection Agency, Centre for Infections, London, UK
C. CAMPBELL
Affiliation:
Health Protection Agency, Centre for Infections, London, UK
M. CHAMBERLAND
Affiliation:
Health Protection Agency, Centre for Infections, London, UK
C. HAWKINS
Affiliation:
Health Protection Agency, Centre for Infections, London, UK
J. S. NGUYEN-VAN-TAM
Affiliation:
University of Nottingham, UK
I. OLIVER
Affiliation:
Health Protection Agency, Local and Regional Services, UK
G. E. SMITH
Affiliation:
Health Protection Agency, Local and Regional Services, UK
C. IHEKWEAZU
Affiliation:
Health Protection Agency, Local and Regional Services, UK
S. BRACEBRIDGE
Affiliation:
Health Protection Agency, Local and Regional Services, UK
H. MAGUIRE
Affiliation:
Health Protection Agency, Local and Regional Services, UK
R. HARRIS
Affiliation:
Health Protection Agency, Centre for Infections, London, UK
G. KAFATOS
Affiliation:
Health Protection Agency, Centre for Infections, London, UK
P. J. WHITE
Affiliation:
Health Protection Agency, Centre for Infections, London, UK MRC Centre for Outbreak Analysis & Modelling, Imperial College London, UK
E. WYNNE-EVANS
Affiliation:
Health Protection Agency, Centre for Infections, London, UK
J. GREEN
Affiliation:
Health Protection Agency, Centre for Infections, London, UK
R. MYERS
Affiliation:
Health Protection Agency, Centre for Infections, London, UK
A. UNDERWOOD
Affiliation:
Health Protection Agency, Centre for Infections, London, UK
T. DALLMAN
Affiliation:
Health Protection Agency, Centre for Infections, London, UK
T. WREGHITT
Affiliation:
Health Protection Agency, Regional Microbiology Network, UK
M. ZAMBON
Affiliation:
Health Protection Agency, Centre for Infections, London, UK
J. ELLIS
Affiliation:
Health Protection Agency, Centre for Infections, London, UK
N. PHIN
Affiliation:
Health Protection Agency, Centre for Infections, London, UK
B. SMYTH
Affiliation:
Public Health Agency for Northern Ireland, Belfast, UK
J. McMENAMIN
Affiliation:
Health Protection Scotland, Glasgow, UK
J. M. WATSON
Affiliation:
Health Protection Agency, Centre for Infections, London, UK
*
*Author for correspondence: Dr R. Pebody, Health Protection Agency, Centre for Infections, 61 Colindale Avenue, London, NW9 5EQ. (Email: Richard.Pebody@hpa.org.uk)
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Summary

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The UK was one of few European countries to document a substantial wave of pandemic (H1N1) 2009 influenza in summer 2009. The First Few Hundred (FF100) project ran from April–June 2009 gathering information on early laboratory-confirmed cases across the UK. In total, 392 confirmed cases were followed up. Children were predominantly affected (median age 15 years, IQR 10–27). Symptoms were mild and similar to seasonal influenza, with the exception of diarrhoea, which was reported by 27%. Eleven per cent of all cases had an underlying medical condition, similar to the general population. The majority (92%) were treated with antiviral drugs with 12% reporting adverse effects, mainly nausea and other gastrointestinal complaints. Duration of illness was significantly shorter when antivirals were given within 48 h of onset (median 5 vs. 9 days, P=0·01). No patients died, although 14 were hospitalized, of whom three required mechanical ventilation. The FF100 identified key clinical and epidemiological characteristics of infection with this novel virus in near real-time.

Keywords

Influenzapandemic
Type
Original Papers
Information
Epidemiology & Infection , Volume 138 , Issue 11 , November 2010 , pp. 1531 - 1541
Copyright
Copyright © Cambridge University Press 2010

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