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Pathogenesis of foot-and-mouth disease: the lung as an additional portal of entry of the virus

Published online by Cambridge University Press:  15 May 2009

P. Sutmoller  and
J. W. McVicar
P. Sutmoller
Affiliation:
Plum Island Animal Disease Center, Northeastern Region, Agricultural Research Service, U.S. Department of Agriculture, Greenport, L.I., New York 11944 U.S.A.
J. W. McVicar
Affiliation:
Plum Island Animal Disease Center, Northeastern Region, Agricultural Research Service, U.S. Department of Agriculture, Greenport, L.I., New York 11944 U.S.A.
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Summary

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Donor cattle infected with foot and mouth disease (FMD) virus subtype O1 were used to expose experimental cattle. The pharyngeal virus growth and viraemia patterns after contact exposure were quite different from those obtained after intranasal inoculation and suggested that the lower respiratory tract might provide an additional portal of entry for the virus. A tracheotomy was performed on experimental cattle to let the respiration bypass the pharynx, followed by exposure to FMD virus by different routes. The results confirmed that FMD virus can enter the bloodstream via the lung, followed by haematogenic infection of the pharynx and other replication sites simultaneously. These observations led to further experiments in which the intravenous route of infection was used to study the interaction of virus growth in the phayrnx, in other sites, and in viraemia.

Type
Research Article
Information
Journal of Hygiene , Volume 77 , Issue 2 , October 1976 , pp. 235 - 243
Copyright
Copyright © Cambridge University Press 1976

References

REFERENCES

Burrows, R., Mann, J. A., Greig, A., Chapmen, W. G. & Goodridge, D. (1971). The growth and persistence of foot-and-mouth disease virus in the bovine mammary gland. Journal of Hygiene 69, 307.CrossRefGoogle ScholarPubMed
Callis, J. J. & Cottral, G. E. (1968). Methods for containment of animal pathogens at the Plum Island Animal Disease Laboratory. Methods in Virology(Ed. Maramorosch, K. and Koprowski, H.), p. 465, Academic Press.Google Scholar
Donaldson, A. I., Herniman, K. A. J., Parker, J. & Sellers, R. F. (1970). Further investigations on the airborne excretion of foot-and-mouth disease virus. Journal of Hygiene 68, 557.Google ScholarPubMed
Eskildsen, M. K. (1968). Experimental pulmonary foot-and-mouth disease infection of cattle. Presented: European Commission for the Control of Foot-and-Mouth Disease. Report of the Meeting of the Research Group of the Standing Technical Committee, State Veterinary Institute for Virus Research, 93 Rome, Food and Agriculture Organization of the United Nations, 124 (1969).Google Scholar
Gailiunas, P. & Cottral, G. E. (1966). Presence and persistence of foot-and-mouth disease virus in bovine skin. Journal of Bacteriology 91, 2333.CrossRefGoogle ScholarPubMed
Graves, J. H., McVicar, J. W., Sutmoller, P. & Trautman, R. (1971). Contact transmission of foot-and-mouth disease from infected to susceptible cattle. Journal of Infectious Diseases 123, 386.CrossRefGoogle ScholarPubMed
Graves, J. H., McVicar, J. W., Sutmoller, P., Trautman, R. & Wagner, G. G. (1971). Latent viral infection in transmission of foot-and-mouth disease by contact between infected and susceptible cattle. Journal of Infectious Diseases 124, 270.CrossRefGoogle ScholarPubMed
Hyslop, N. St G. (1965). Airborne infection with the virus of foot-and-mouth disease. Journal of Comparative Pathology 75, 119.CrossRefGoogle ScholarPubMed
Korn, G. (1957). Experimentelle Untersuchungen zum Virusnachweis im Inkubations-stadium der Maul – und Klauenseuche und zu ihrer Pathogenese. Archiv für experimentelle Veterinaermedizin 11, 637.Google Scholar
McVicar, J. W., Graves, J. H. & Sutmoller, P. (1970). The growth of foot-and-mouth disease virus in the bovine pharynx. United States Animal Health Association Proceedings 74, 230.Google Scholar
McVicar, J. W. & Sutmoller, P. (1974). Neutralizing activity in the serum and oesophageal-pharyngeal fluid of cattle after exposure to foot-and-mouth disease virus and subsequent re-exposure. Archiv für die gesamte Virusforschung 44, 173.CrossRefGoogle ScholarPubMed
McVicar, J. W. & Sutmoller, P. (1976). The growth of foot-and-mouth disease virus in the upper respiratory tract of non-immunized, vaccinated, and recovered cattle after intranasal inoculation. Journal of Hygiene 76, 467.CrossRefGoogle ScholarPubMed
McVicar, J. W., Sutmoller, P. & Andersen, A. A. (1974). Foot-and-mouth disease virus: Plaque reduction neutralization test. Archiv für die gesamte Virusforschung 44, 168.CrossRefGoogle Scholar
Mims, C. A. (1964). Aspects of the pathogenesis of virus diseases. Bacteriological Reviews 28, 30.CrossRefGoogle ScholarPubMed
Seibold, H. R. (1963). A revised concept of the lingual lesions in cattle with foot-and-mouth disease. American Journal of Veterinary Research 24, 1123.Google ScholarPubMed
Sellers, R. F., Barlow, D. F., Donaldson, A. I., Herniman, K. A. J. & Parker, J. (1973). Foot-and-mouth disease: A case study of airborne disease. In: International Symposium of Aerobiology iv, 405, Utrecht: Oosthoek Publishing Company.Google Scholar
Sellers, R. F., Donaldson, A. I. & Herniman, K. A. J. (1970). Inhalation, persistence, and dispersal of foot-and-mouth disease virus by man. Journal of Hygiene 68, 565.Google ScholarPubMed
Sellers, R. F. & Parker, J. (1969). Airborne excretion of foot-and-mouth disease virus. Journal of Hygiene 67, 671.Google ScholarPubMed
Skinner, H. H. & Knight, E. H. (1964). Environmental factors influencing the response of guinea-pigs to modified strains of foot-and-mouth disease virus. Bulletin of the Office International des Epizooties. 61, 1523.Google Scholar
Sutmoller, P. (1971). Persistent foot-and-mouth disease virus infections. In: International Symposium on Medical and Applied Virology, III. Ft. Lauderdale, Fla. 1970; Viruses Affecting Man and Animals; 295, compiled and edited by Sanders, Murray, and Schaeffer, Morris. St. Louis, Missouri, Green, xvii, 459.Google Scholar
Sutmoller, P., Graves, J. H. & McVicar, J. W. (1970). Influence of enterovirus on foot-and-mouth disease virus infection. A hypothesis. United States Animal Health Association Proceedings 74, 235.Google Scholar
Sutmoller, P. & McVicar, J. W. (1972). Three variants of foot-and-mouth disease virus, type O: III. Exposure of cattle. American Journal of Veterinary Research 33, 1641.Google Scholar
Sutmoller, P. & McVicar, J. W. (1976). Pathogenesis of foot-and-mouth disease: clearance of virus from the circulation of cattle and goats during experimental viraemia. Journal of Hygiene, 77, 245.CrossRefGoogle ScholarPubMed