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The Phases of Haemophilus pertussis

  • P. H. Leslie (a1) and A. D. Gardner (a1)

Haemophilus pertussis is a uniform species, without fixed varieties or “types.”

After isolation from the human subject it tends to pass through a series of antigenically distinct phases, of which the first two are toxic to guinea-pigs, whereas the last two are relatively harmless. The former probably correspond to the smooth, the latter to the rough phase of other bacteria.

The phase-changes are, up to a point, reversible.

Experiments on guinea-pigs have produced some evidence that the toxic Phase I is the best and perhaps the only antigen for the production of active immunity in guinea-pigs.

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G. Dreyer and W. Ray (1911). Phil. Trans. Royal Soc. (London), B, 202, 191.

C. Krumwiede , L. Mishulow and C. Oldenbusch (1923). J. Infect. Dis. 32, 22.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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