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Plague metapopulation dynamics in a natural reservoir: the burrow system as the unit of study

  • S. DAVIS (a1), N. KLASSOVSKIY (a2), V. AGEYEV (a2), B. SULEIMENOV (a2), B. ATSHABAR (a2), A. KLASSOVSKAYA (a2), M. BENNETT (a3), H. LEIRS (a1) (a4) and M. BEGON (a3)...

The ecology of plague (Yersinia pestis infection) in its ancient foci in Central Asia remains poorly understood. We present field data from two sites in Kazakhstan where the great gerbil (Rhombomys opimus) is the major natural host. Family groups inhabit and defend burrow systems spaced throughout the landscape, such that the host population may be considered a metapopulation, with each occupied burrow system a subpopulation. We examine plague transmission within and between family groups and its effect on survival. Transmission of plague occurred disproportionately within family groups although not all gerbils became infected once plague entered a burrow system. There were no spatial patterns to suggest that family groups in close proximity to infected burrow systems were more at risk of infection than those far away. At one site, infection increased the chances of burrow-system extinction. Overall, it is useful to consider the burrow system as the unit of study within a much larger metapopulation.

Corresponding author
*Author for correspondence: Dr S. Davis, Faculty of Veterinary Medicine, University of Utrecht, Theoretical Epidemiology, Yalelaan 7, 3584 CL Utrecht, The Netherlands. (Email:
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1. Tikhomirov E. Epidemiology and distribution of plague. In: Dennis DT, Gage KL, Gratz N, Poland JD, Tikhomirov E eds. Plague Manual. Geneva: World Health Organisation, 1999, pp. 1142.
2. Davis S, et al. Predictive thresholds for plague in Kazakhstan. Science 2004; 304: 736738.
3. Frigessi A, et al. Bayesian population dynamics of interacting species: great gerbils and fleas in Kazakhstan. Biometrics 2005; 61: 230238.
4. Begon M, et al. Epizootiological parameters for plague (Yersinia pestis infection) in a natural reservoir in Kazakhstan. Emerging Infectious Diseases 2006; 12: 268273.
5. Pollitzer R. Plague and Plague Control in the Soviet Union. New York: Fordham University, 1966.
6. Gratz N. Rodent reservoirs and flea vectors of natural foci of plague. Plague Manual: epidemiology, distribution, surveillance and control. Geneva: World Health Organisation, 1999, pp. 6396.
7. Gage KL, Kosoy MY. Natural history of plague: perspectives from more than a century of research. Annual Review of Entomology 2004; 50: 505528.
8. Kunitskiy VN, Gauztein DM. Ecological groups of the gerbil's fleas and their importance in natural focality of plague, pp. 5961. Saratov. Material to conference devoted to the Institute ‘Microbe’'s 50th anniversary, 1968.
9. Naumov NP, Lobachev VS. Ecology of desert rodents of the USSR (Jerboas and Gerbils). Great Gerbil. In: Prakash I, Ghosh PK eds. Rodents in Desert Environments, 1975, pp. 549598.
10. Rothschild VE. Spatial Structure of Plague Natural Focus and Methods of its Study. Moscow: Publishing House of Moscow University, 1978.
11. Randall JA, Rogovin KA. Variation in and meaning of alarm calls in a social desert rodent Rhombomys opimus. Ethology 2002; 108: 513527.
12. Hess GR. Conservation corridors and contagious disease: a cautionary note. Conservation Biology 1994; 8: 256262.
13. Hess GR. Disease in metapopulation models: implications for conservation. Ecology 1996; 77: 16171632.
14. Gog J, Woodroffe R, Swinton J. Disease in endangered metapopulations: the importance of alternative hosts. Proceedings of the Royal Society of London, Series B: Biological Sciences 2002; 269: 671676.
15. McCallum H, Dobson A. Disease, habitat fragmentation and conservation. Proceedings of the Royal Society of London Series B: Biological Sciences 2002; 269: 20412049.
16. Keeling MJ, Gilligan CA. Bubonic plague: a metapopulation model of a zoonosis. Proceedings of the Royal Society of London, Series B: Biological Sciences 2000; 267: 22192230.
17. Xia YC, Bjornstad ON, Grenfell BT. Measles metapopulation dynamics: a gravity model for epidemiological coupling and dynamics. American Naturalist 2004; 164: 267281.
18. Stapp P, Antolin MF, Ball M. Patterns of extinction in prairie dog metapopulations: plague outbreaks follow El Niño events. Frontiers in Ecology and Environment 2004; 2: 235240.
19. Biggins DE, Kosoy MY. Influences of introduced plague on North American mammals: Implications from ecology of plague in Asia. Journal of Mammalogy 2001; 82: 906916.
20. MacIntyre S, Knight SD, Fooks LJ. Structure, assembly and applications of the polymeric F1 antigen of Yersinia pestis. In: Carniel E, Hinnebusch BJ eds. Yersinia Molecular and Cellular Biology. Norfolk: Horizon Bioscience, 2004, pp. 363407.
21. Ineichen R, Batschelet E. Genetic selection and de Finetti diagrams. Journal of Mathematical Biology (Historical Archive) 1974; 2: 3339.
22. Diggle PJ. Statistical Analysis of Spatial Point Patterns. London: Arnold, 2003.
23. Lawton JH, et al. Animal distributions: patterns and processes. In: Edwards PJ, May RM, Webb NR eds. Large-scale Ecology and Conservation Biology. Oxford: Blackwell, 1994, pp. 4158.
24. Grenfell BT, Harwood J. (Meta)population dynamics of infectious diseases. Trends in Ecology & Evolution 1997; 12: 395399.
25. Gulland FMD. Impact of infectious diseases on wild animal populations: a review. In: Grenfell BT, Dobson AP eds. Ecology of Infectious Diseases in Natural Populations. Cambridge: Cambridge University Press, 1995, pp. 2051.
26. Korneyev GA. The quantitative characteristics of parasitic exchange in some mammals species resulting from simulation of epizootics in desert biocenoses, 1968. Microbe Institute, Saratov.
27. Rudenchik YuV, et al. Quantitative evaluation of the possibility of the territorial advance of epizooty of plague in the population of the Rhombymus opimus (northern Karakum). Zoological Zhurnal 1967; 46: 117123.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
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