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Polyvinyl-pyrrolidone-iodine: an assessment of antibacterial activity

  • B. A. Saggers (a1) and G. T. Stewart (a1)

Extract

Polyvinyl-pyrrolidone-iodine complex (PVP-I) was shown to have a rapid disinfectant activity in vitro against vegetative bacteria and fungi and against vegetative Trichomonas. The presence of organic matter had a slight delaying effect on the killing time. Bacterial spores survived in PVP-I for 17 hr. and fungal spores for 1½ hr. Used as an agent for pre-operative preparation of the skin, PVP-I was more efficient than others tested, rendering the skin surface sterile even when heavily contaminated, and keeping it so for 1 hr. None of the staining characteristics of iodine were noted since PVP-I was easily removed by water. Two individuals, known to be iodine sensitive, developed mild iodism after application of PVP-I.

The authors are indebted to the staff of the hospital for their co-operation; and to Berk Pharmaceuticals Limited for supplies of PVP-I, manufactured by them as Betadine (Povidone-iodine B.P.).

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Copyright

References

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Gershenfeld, L. (1962). Povidone-iodine as a sporicide. Amer. J. Pharm. 134, 78.
Joress, S. M. (1962). A study of disinfection of the skin: A comparison of Povidone-iodine with other agents used for surgical scrubs. Ann. Surg. 155, 296.
Lederberg, J. & Lederberg, E. M. (1952). Replica plating and indirect selection of bacterial mutants. J. Bact. 63, 399.
Lenhardt, H. F. & Lachapelle, N. C. (1961). Povidone-iodine as a topical antiseptic. Virginia med. (Semi-)Month. 88, 454.
Lowbury, E. J. L., Lilly, H. A. & Bull, J. P. (1963). Disinfection of hands, removal of resident bacteria. Brit. med. J. i, 1251.
Shelanski, H. A. & Shelanski, M. V. (1956). P.V.P.-iodine: History, toxicity and therapeutic uses. J. int. Coll. Surg. 25, 727.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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