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Polyvinyl-pyrrolidone-iodine: an assessment of antibacterial activity

Published online by Cambridge University Press:  15 May 2009

B. A. Saggers
Affiliation:
Department of Pathology, Queen Mary's Hospital for Children, Carshalton, Surrey
G. T. Stewart
Affiliation:
Department of Pathology, Queen Mary's Hospital for Children, Carshalton, Surrey
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Extract

Polyvinyl-pyrrolidone-iodine complex (PVP-I) was shown to have a rapid disinfectant activity in vitro against vegetative bacteria and fungi and against vegetative Trichomonas. The presence of organic matter had a slight delaying effect on the killing time. Bacterial spores survived in PVP-I for 17 hr. and fungal spores for 1½ hr. Used as an agent for pre-operative preparation of the skin, PVP-I was more efficient than others tested, rendering the skin surface sterile even when heavily contaminated, and keeping it so for 1 hr. None of the staining characteristics of iodine were noted since PVP-I was easily removed by water. Two individuals, known to be iodine sensitive, developed mild iodism after application of PVP-I.

The authors are indebted to the staff of the hospital for their co-operation; and to Berk Pharmaceuticals Limited for supplies of PVP-I, manufactured by them as Betadine (Povidone-iodine B.P.).

Type
Research Article
Copyright
Copyright © Cambridge University Press 1964

References

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