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Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011–2012

  • L. N. M. HOA (a1), J. E. BRYANT (a1) (a2), M. CHOISY (a1) (a3), L. A. NGUYET (a1), N. T. BAO (a1), N. H. TRANG (a1), N. T. K. CHUC (a4), T. K. TOAN (a4), T. SAITO (a5), N. TAKEMAE (a5), P. HORBY (a1) (a2), H. WERTHEIM (a1) (a2) and A. FOX (a1) (a6)...

Summary

A reassortant swine-origin A(H3N2) virus (A/swine/BinhDuong/03-9/2010) was detected through swine surveillance programmes in southern Vietnam in 2010. This virus contains haemagglutinin and neuraminidase genes from a human A(H3N2) virus circulating around 2004–2006, and the internal genes from triple-reassortant swine influenza A viruses (IAVs). To assess population susceptibility to this virus we measured haemagglutination inhibiting (HI) titres to A/swine/BinhDuong/03-9/2010 and to seasonal A/Perth/16/2009 for 947 sera collected from urban and rural Vietnamese people during 2011–2012. Seroprevalence (HI ⩾ 40) was high and similar for both viruses, with 62·6% [95% confidence interval (CI) 59·4–65·7] against A/Perth/16/2009 and 54·6% (95% CI 51·4–57·8%) against A/swine/BinhDuong/03-9/2010, and no significant differences between urban and rural participants. Children aged <5 years lacked antibodies to the swine origin H3 virus despite high seroprevalence for A/Perth/16/2009. These results reveal vulnerability to infection to this contemporary swine IAV in children aged <5 years; however, cross-reactive immunity in adults would likely limit epidemic emergence potential.

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Copyright

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Corresponding author

* Author for correspondence: J. E. Bryant, Oxford University Clinical Research Unit Vietnam, National Hospital of Tropical Diseases, 78 Giai Phong Street, Dong Da District, Hanoi, Vietnam (Email: jbryant@oucru.org)

References

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Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011–2012

  • L. N. M. HOA (a1), J. E. BRYANT (a1) (a2), M. CHOISY (a1) (a3), L. A. NGUYET (a1), N. T. BAO (a1), N. H. TRANG (a1), N. T. K. CHUC (a4), T. K. TOAN (a4), T. SAITO (a5), N. TAKEMAE (a5), P. HORBY (a1) (a2), H. WERTHEIM (a1) (a2) and A. FOX (a1) (a6)...

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