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Population-based contact investigation of a cluster of tuberculosis cases in a small village

  • J. CASTILLA (a1) (a2), R. PALMERA (a3), A. NAVASCUÉS (a4), M. ABETI (a5), A. GUILLERMO (a5), F. IRISARRI (a1) (a2), M. S. JIMÉNEZ (a6), M. GARCÍA CENOZ (a1) (a2) and A. BARRICARTE (a1) (a2)...
Abstract
SUMMARY

A cluster of five cases of tuberculosis (TB) in persons aged 19–23 years who were not close contacts was detected in a small village in Spain in 2006. All culture isolates had the same chromosomal-DNA restriction pattern. Contact investigations of family members, friends, workmates and schoolmates were complemented with tuberculin screening offered to the resident population born between 1976 and 1995. Expanded contact tracing detected two new cases of TB, 27 tuberculin conversions and an excess of latent tuberculosis infections (LTI) in persons born between 1978 and 1990. The contacts of two cases had a significantly elevated prevalence of LTI. Two secondary cases of TB, 33·3% of those diagnosed with LTI and 47·8% of the converters were unaware of any contact with the TB cases, but had frequented some of the same bars. This study suggests that a considerable percentage of the episodes of TB transmission in young people may escape detection in conventional contact studies.

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Corresponding author
*Author for correspondence: Dr J. Castilla, Instituto de Salud Pública de Navarra. Leyre 15, 31003 Pamplona, Navarra, Spain. (Email: jcastilc@navarra.es)
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1. CM Bran , Study of tuberculosis outbreaks reported in Catalonia, 1998–2002. Archivos de Bronconeumología 2006; 42: 260266.

3. A Sánchez Marenco , Epidemic outbreak of tuberculosis in a primary and secondary school in Granada (Spain). Anales de Pediatría 2003; 58: 432437.

11. J Elizaga , Recent transmission of tuberculosis in an area with low incidence: epidemiological and molecular study. Medicina Clínica (Barcelona) 2002; 118: 645649.

15. M Yates , FA Drobniewski , SM Wilson . Evaluation of a rapid PCR-based epidemiological typing method for routine studies of Mycobacterium tuberculosis. Journal of Clinical Microbiology 2002; 40: 712714.

16. CR MacIntyre , High rates of transmission of tuberculosis in an office: impact of delayed diagnosis. Clinical Infectious Diseases 1995; 21: 11701174.

17. BM Allos , Management of an outbreak of tuberculosis in a small community. Annals of Internal Medicine 1996; 125: 114117.

18. CM Kettunen , Contact investigation of a case of active tuberculosis in the community. American Journal of Infection Control 2007; 35: 421424.

21. N Bock , Outbreak of tuberculosis associated with a floating card game in the rural south: lessons for tuberculosis contact investigations. Clinical Infectious Diseases 1998; 27: 12211226.

23. Y Nakamura , A small outbreak of pulmonary tuberculosis in non-close contact patrons of a bar. Internal Medicine 2004; 43: 263267.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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