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Prevalence of hepatitis C virus and hepatitis B virus infections in HIV-positive Chinese patients

  • Y. X. YAN (a1), Y. Q. GAO (a2), X. SUN (a2), W. WANG (a1), X. J. HUANG (a2), T. ZHANG (a2), M. LI (a1), C. P. ZANG (a3), Z. C. LI (a2) and H. WU (a2)...
Summary
SUMMARY

To evaluate the prevalence of hepatitis C virus (HCV) and/or hepatitis B virus (HBV) infections in HIV-infected patients in China, an epidemiological serosurvey was conducted from May 2007 to September 2008 using a random cluster sampling design of infectious disease hospitals in seven high HIV-prevalent provinces (municipalities). Univariate analysis and logistic regression were used to study the determinants of HIV and HBV and/or HCV co-infection. The overall prevalence was 41·83% (95% CI 40·36–43·30) for anti-HCV and 12·49% (95% CI 11·50–13·48) for HBsAg, respectively. The prevalence of anti-HCV and HBsAg varied according to the route of HIV transmission. Compared to those with sexually acquired HIV infection, intravenous drug users and blood donors/recipients had the greatest risk of carrying anti-HCV. Needle sharing and unprotected sexual exposures are important modes of transmission for HBV. Further interventions including health education and harm reduction strategies should be implemented in high-risk populations.

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Corresponding author
*Author for correspondence: Dr Hao Wu, STD and AIDS Clinical Center, Beijing Youan Hospital, Capital Medical University, No. 8 Xitoutiao, You An Men, Beijing 100069, P.R. China. (Email: wuccmu2010@163.com)
References
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1.Thimme R, Spangenberg HC, Blum HE. Hepatitis B or hepatitis C and human immunodeficiency virus infection. Journal of Hepatology 2005; 42: S37S44.
2.Rockstroh JK. Influence of viral hepatitis on HIV infection. Journal of Hepatology 2006; 44: S25S27.
3.Liang XF, et al. A study on the sero-epidemiology of hepatitis B in Chinese population aged over 3-years old: the report from Chinese Center for Disease Control and Prevention. Chinese Journal of Epidemiology 2005; 26: 655658.
4.Liang X, et al. Epidemiological serosurvey of hepatitis B in China – declining HBV prevalence due to hepatitis B vaccination. Vaccine 2009; 27: 65506557.
5.Kang LY, et al. Studies on epidemiology of the population with HCV and HEV infections and their epidemic factors in China. Chinese Journal Infectious Diseases 1997; 15: 7175.
6.Watts J. Sex, drugs, and HIV/AIDS in China. Lancet 2008; 1371: 103104.
7.Gill B, Okie S. China and HIV – a window of opportunity. New England Journal of Medicine 2007; 356: 18011805.
8.Ministry of Health of the Peoples Republic of China. Chinese Health Statistics Yearbook (2009). Beijing: Beijing Union Medical College Press, 2009, pp. 238239.
9.Sherman KE, et al. Hepatitis C virus prevalence among patients infected with human immunodeficiency virus: a cross-sectional analysis of the US Adult AIDS Clinical Trials Group. Clinical Infectious Diseases 2002; 34: 831837.
10.Larsen C, et al. Prevalence of hepatitis C and hepatitis B virus infections in HIV infected persons (France, 2004). Journal of Clinical Virology 2006; 36: S190.
11.Dimitrakopoulos A, et al. The prevalence of hepatitis B and C in HIV-positive Greek patients: relationship to survival of deceased AIDS patients. Journal of Infection 2000; 40: 127131.
12.Nyirenda M, et al. Prevalence of infection with hepatitis B and C virus and coinfection with HIV in medical patientsin Malawi. Journal of Infection 2008; 57: 7277.
13.Wasley A, Alter M. Epidemiology of hepatitis C: geographic differences and temporal trends. Seminars in Liver Disease 2000; 20: 116.
14.Xia X, et al. Epidemiology of hepatitis C virus infection among injection drug users in China: systematic review and meta-analysis. Public Health 2008; 122: 990–1003.
15.Li DM, Shun XH, Zeng G. National HIV sentinel surveillance for high-risk population in China in 2005. Chinese Journal of AIDS and STD 2007; 13: 13.
16.Zhang W, et al. Spread of HIV in one village in central China with a high prevalence rate of blood-borne AIDS. International Journal of Infectious Diseases 2006; 10: 475480.
17.Yang H, et al. Heterosexual transmission of HIV in China: a systematic review of behavioral studies in past two decades. Sexually Transmitted Diseases 2005; 32: 270280.
18.Settle E. HIV/AIDS Policy issues. China AIDS survey (http://www.casy.org/overview.htm). Accessed 3 September 2004.
19.Li X, et al. HIV/STD risk behaviors and perceptions among rural-to-urban migrants in China. AIDS Education and Prevention 2004; 16, 538556.
20.Zhang KL, Ma SJ. Epidemiology of HIV in China. British Medical Journal 2002; 324: 803804.
21.Thio CL, et al. HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS). Lancet 2002; 360: 19211926.
22.Kellerman SE, et al. Prevalence of chronic hepatitis B and incidence of acute hepatitis B infection in human immunodeficiency virus-infected subjects. Journal of Infectious Diseases 2003; 188: 571577.
23.Konopnicki D, et al. Hepatitis B and HIV: prevalence, AIDS progression, response to highly active antiretroviral therapy and increased mortality in the EuroSIDA cohort. AIDS 2005; 19: 593601.
24.Shang G, et al. Two HBV DNA+/HBsAg- blood donors identified by HBV NAT in Shenzhen, China. Transfusion and Apheresis Science 2009; 41: 37.
25.Jia GU. Prevention of mother-to-infant transmission of HIV: a new programme in China. Chinese Medical Journal 2003; 116: 1292.
26.China Ministry of Health, China Center for Disease Control and Prevention. Working guidelines to prevent mother to child transmission of HIV. November 2004 (www.chinaids.org.cn). Accessed 27 March 2005.
27.Wu Z, et al. Evolution of China's response to HIV/AIDS. Lancet 2007; 369: 679690.
28.Gu J, et al. Severity of drug dependence, economic pressure and HIV-related risk behaviors among non-institutionalized female injecting drug users who are also sex workers in China. Drug and Alcohol Dependence 2008; 97: 257267.
29.Yang Z, et al. HCV positivity rate in the seronegative blood donors in China. Biomedicine and Pharmacotherapy 2009; 63: 319320.
30.Soldan K, Davison K, Dow B. Estimates of the frequency of HBV, HCV and HIV infectious donations entering the blood supply in the United Kingdom, 1996–2003. Eurosurveillance 2005; 10: 1719.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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