Skip to main content
×
Home
    • Aa
    • Aa

Prevalence of human astrovirus serotype 4: capsid protein sequence and comparison with other strains

  • M. M. Willcocks (a1), J. B. Kurtz (a2), T. W. Lee (a2) and M. J. Carter (a1)
Abstract
Summary

Astrovirus serotype 4 has increased in relative prevalence in the Oxford, UK area in 1993. The structural gene of human astrovirus serotype 4 has been sequenced and the results indicate that this protein differs substantially from serotypes 1 and 2. In particular, conservation at the C terminus is greatly reduced. However, amino acid substitutions in this region show a strong conservation in character suggesting that structural or functional constraints operate in this region.

Copyright
Corresponding author
* Author for correspondence.
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1. CR Madeley , BP Cosgrove . Viruses in infantile gastroenteritis. Lancet 1975; ii: 124.

2. CR Madeley , BP Cosgrove . 28 nm particles in faeces in infantile gastroenteritis. Lancet 1975; ii: 451–2.

3. MM Willcocks , MJ Carter , CR Madeley . Astroviruses. Rev Med Virol 1992; 2: 97106.

5. LS Oshiro , CE Haley , RR Roberts , A 27 nanometre virus isolated during an outbreak of acute infectious nonbacterial gastroenteritis in a convalescent hospital: a possible new serotype. J Infect Dis 1981; 143: 791–5.

7. JG Silcock , MM Willcocks , A Codd , MJ Carter , CO Record . Virus involvement in community acquired diarrhoea examined by stool dot-blot hybridization and electron microscopy. Europ J Gastroent Hepatol 1993; 5: 601–6.

8. AR Oliver , AD Phillips . An electron microscopical investigation of faecal small round viruses. J Med Virol 1988; 24: 211–18.

9. JE Herrmann , DN Taylor , P Echeverria , NR Blacklow . Astroviruses as a cause of gastroenteritis in children. N Eng J Med 1991; 324: 1757–60.

12. I Oishi , K Yamazaki , T Kimoto , A large outbreak of acute gastroenteritis associated with astrovirus among students and teachers in Osaka, Japan. J Infect Dis 1994; 170: 439–43.

13. S Myint , R Manley , WD Cubitt . Viruses in bathing waters. Lancet 1994; 343: 1640–1.

15. JB Kurtz , TW Lee . Human astrovirus serotypes. Lancet 1984; ii: 1405.

16. TW Lee , JB Kurtz . Serial propagation of astrovirus in tissue culture with the aid of trypsin. J Gen Virol 1981; 57: 421–4.

17. MM Willcocks , MJ Carter , FR Laidler , CR Madeley . Growth and characterization of human faecal astrovirus in a continuous cell line. Arch Virol 1990; 113: 7382.

18. MM. Willcocks MJ Carter . The 3′ terminal sequence of a human astrovirus. Arch Virol 1992; 124: 279–89.

19. MM Willcocks , MJ Carter . Identification and sequence determination of the capsid protein gene of human astrovirus serotype 1. FEMS Micro Lett 1993; 114: 18.

21. MM Willcocks , CR Madeley , TDK Brown , MJ Carter . The complete sequence of a human astrovirus. J Gen Virol 1994; 75: 1785–8.

22. B Jiang , SS Monroe , EV Koonin , SE Stine , RI Glass . RNA sequence of astrovirus: distinctive genomic organization and a putative retrovirus-like ribosomal frame-shifting signal that directs the viral replicase synthesis. Proc Natl Acad Sci USA 1993; 90: 10539–43.

26. A Sanchez-Fauquier , AL Carrascosa , JL Carrascosa , Characterisation of a human astrovirus serotype 2 structural protein (VP26) that contains an epitope involved in virus neutralization. Virology 1994; 201: 312–20.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 1 *
Loading metrics...

Abstract views

Total abstract views: 13 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 22nd May 2017. This data will be updated every 24 hours.