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Prevalence of human astrovirus serotype 4: capsid protein sequence and comparison with other strains

  • M. M. Willcocks (a1), J. B. Kurtz (a2), T. W. Lee (a2) and M. J. Carter (a1)

Astrovirus serotype 4 has increased in relative prevalence in the Oxford, UK area in 1993. The structural gene of human astrovirus serotype 4 has been sequenced and the results indicate that this protein differs substantially from serotypes 1 and 2. In particular, conservation at the C terminus is greatly reduced. However, amino acid substitutions in this region show a strong conservation in character suggesting that structural or functional constraints operate in this region.

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