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Prospective evaluation of latent tuberculosis with interferon-γ release assays in drug and alcohol abusers

  • I. RIVAS (a1), I. LATORRE (a2), A. SANVISENS (a1), J. DOMÍNGUEZ (a2), J. TOR (a1), C. PRAT (a2), C. REY-JOLY (a1) and R. MUGA (a1)
  • DOI: http://dx.doi.org/10.1017/S0950268809002131
  • Published online: 26 February 2009
Abstract
SUMMARY

In vitro tests have been developed for the diagnosis of tuberculosis (TB) infection. The objective was to analyse latent TB infection in drug and alcohol abusers through two interferon-γ techniques. One hundred and thirty-nine patients were admitted between February 2006 and May 2007. Mean age was 39·8 years [31% HIV positive]. The enzyme immunoassay (EIA) and enzyme-linked immunospot (ELISPOT) interferon-γ assays were positive in 34% of patients with an agreement of 83% (κ=0·63). Tuberculin skin test (TST) was positive in 29% of patients and the agreement of TST with EIA and ELISPOT interferon-γ assays was 85% (κ=0·62) and 83% (κ=0·57), respectively. Almost 50% of patients with history of TB had a positive in vitro test. In conclusion, we observed a high prevalence of latent TB and good agreement between the new in vitro tests that otherwise may continue to be positive long after developing TB disease.

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Corresponding author
*Author for correspondence: R. Muga, M.D., Ph.D., Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Carretera Canyet s/n, 08916Badalona, Barcelona. (Email: rmuga.germanstrias@gencat.cat)
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4.L Friedman , Tuberculosis, AIDS and death among substance abusers on welfare in New York City. New England Journal of Medicine 1996; 334: 828833.

6.S Moreno , Risk for developing tuberculosis among anergic patients infected with HIV. Annals of Internal Medicine 1993; 119: 194198.

8.R Muga , Changes in the incidence of tuberculosis in a cohort of HIV-seroconverters before and after the introduction of HAART. AIDS 2007; 21: 25212527.

9.PA Selwyn , A prospective study of the risk of tuberculosis among intravenous drug users with human immunodeficiency virus infection. New England Journal of Medicine 1989; 320: 545550.

10.C Horsburgh . Priorities for the treatment of latent tuberculosis infection in the United States. New England Journal of Medicine 2004; 350: 20602067.

11.LE Duncan , Tuberculin sensitivity and HIV-1 status of patients attending a sexually transmitted diseases clinic in Lusaka, Zambia: a cross-sectional study. Transactions of the Royal Society of Tropical Medicine and Hygiene 1995; 89: 3740.

12.L Richeldi . An update on the diagnosis of tuberculosis infection. American Journal of Respiratory and Critical Care Medicine 2006; 174: 736742.

13.PJ Converse , Comparison of a tuberculin Interferon-gamma assay with the tuberculin skin test in high-risk adults: effect of human immunodeficiency virus infection. Journal of Infectious Diseases 1997; 176: 144150.

14.M Pai , LW Riley , JM Colford . Interferon gamma assays in the immunodiagnosis of tuberculosis: a systematic review. Lancet Infectious Diseases 2004; 4: 761776.

15.SM Arend , Tuberculin skin testing and in vitro T cell responses to ESAT-6 and culture filtrate protein 10 after infection with Mycobacterium marinum or M. kansasii. Journal of Infectious Diseases 2002; 186: 17971807.

16.D Menzies , M Pai , G Comstock . Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research. Annals of Internal Medicine 2007; 146: 340354.

17.A Lalvani , Enumeration of T cells specific for RDI-encoded antigens suggest a high prevalence of latent Mycobacterium tuberculosis infection in healthy urban Indians. Journal of Infectious Diseases 2001; 183: 469477.

18.M Kimura , Comparison between a whole blood interferon-γ release assay and tuberculin skin testing for the detection of tuberculosis infection among patients at risk for tuberculosis exposure. Journal of Infectious Diseases 1999; 179: 12971300.

19.PK Dewan , Feasibility, acceptability, and cost of tuberculosis testing by whole-blood interferon-gamma assay. BMC Infectious Diseases 2006; 6: 47.

21.G Ferrara , Use in routine clinical practice of two commercial blood tests for diagnosis of infection with Mycobacterium tuberculosis: a prospective study. Lancet 2006; 367: 13281334.

22.S Liebeschuetz , Diagnosis of tuberculosis in South African children with a T-cell-based assay: a prospective cohort study. Lancet 2004; 364: 21962203.

23.EW Taggart , Evaluation of an In Vitro assay for Interferon gamma production in response to the Mycobacterium tuberculosis-synthesized peptide antigens ESAT-6 and CFP-10 and the PPD skin test. American Journal of Clinical Pathology 2006; 125: 467473.

24.SJ Tsiouris , Sensitivity analysis and potential uses of a novel gamma interferon release assay for diagnosis of tuberculosis. Journal of Clinical Microbiology 2006; 44: 28442850.

25.AL Chapman , Rapid detection of active and latent tuberculosis infection in HIV positive individuals by enumeration of Mycobacterium tuberculosis-specific T cells. AIDS 2002; 16: 22852293.

26.I Brock , Latent tuberculosis in HIV positive, diagnosed by the M. tuberculosis specific Interferon Gamma test. Respiratory Research 2006; 7: 56.

27.MX Rangaka , Effect of HIV-infection on T-cell-based and skin test detection of tuberculosis infection. American Journal of Respiratory and Critical Care Medicine 2007; 175: 514520.

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