Hostname: page-component-848d4c4894-ndmmz Total loading time: 0 Render date: 2024-05-22T05:08:54.363Z Has data issue: false hasContentIssue false
  • English
  • Français

Quaternary ammonium compounds. A new technique for the study of their bactericidal action and the results obtained with cetavlon* (Cetyltrimethylammonium bromide)

Published online by Cambridge University Press:  15 May 2009

G. E. Davies
G. E. Davies
Affiliation:
From Imperial Chemical Industries Ltd, Biological Laboratories, Hexagon House, Blackley, Manchester
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Some sources of error in the testing of quaternary ammonium compounds for bactericidal activity have been investigated. These resolve themselves into (a) errors caused by bacteriostasis, and (b) errors caused by the clumping of bacteria.

2. A suitable technique, free from these errors, is described.

3. Cetavlon in 0·1% solution is a powerful bactericide even in the presence of moderate amounts of organic matter.

4. One per cent Cetavlon will not kill spores at room temperature even when contact is maintained for several days.

5. Bacteria surviving the action of quaternary ammonium compounds retain their virulence.

Type
Research Article
Information
Journal of Hygiene , Volume 47 , Issue 3 , November 1949 , pp. 271 - 277
Copyright
Copyright © Cambridge University Press 1949

References

REFERENCES

Barnes, J. M. (1942). Lancet, 1, 531–2.CrossRefGoogle Scholar
Blubaugh, L. V., Grewe, E. G., Botts, C. W. & Helvig, H. L. (1940). J. Bact. 41, 34–5.Google Scholar
Davies, G. E. & Fishburn, A. G. (1946). Quart. J. Pharm. Pharmacol. 19, 365–72.Google Scholar
Domagk, G. (1935). Dtsch. Med. Wschr. 61, 829–32.CrossRefGoogle Scholar
Du Bois, A. S. (1947). Soap and San. Chem. 23, 139.Google Scholar
Du Bois, A. S. & Dibblee, D. (1946). Science. 103, 734.CrossRefGoogle Scholar
Du Bois, A. S. & Dibblee, D. (1947). Quoted by Du Bois, 1947.Google Scholar
Graydon, J. J. & Biggs, C. L. (1942). Med. J. Aust. 2, 513–15.CrossRefGoogle Scholar
Green, T. W. & Birkeland, J. M. (1941). J. Bact. 41, 34.Google Scholar
Heinemann, P. G. (1937). J. Amer. Pharm. Ass. 26, 711–17.Google Scholar
Kenner, B. A., Quisno, R. A., Foter, M. J. & Gibby, I. W. (1946). J. Bact. 52, 449–51.CrossRefGoogle Scholar
Kivela, E. W., Mallmann, W. L. & Churchill, E. S. (1948). J. Bact. 55, 565–72.CrossRefGoogle Scholar
Klarmann, E. G. & Wright, E. S. (1946). Soap and San. Chem. 22, 125.Google Scholar
Klarman, E. G. & Wright, E. S. (1948). Amer. J. Pharm. 120, 146–57.Google Scholar
Mallmann, W. L. & Hands, M (1945). J. Bact. 49, 528.Google Scholar
Mallmann, W. L. & Leavttt, A. H (1948). Amer. J. Vet. Res. 9, 104–8.Google Scholar
McCullooh, E. C. (1947). Science. 105, 480–1.CrossRefGoogle Scholar
McCulloch, E. C, Hauge, S. & Migaki, H. (1948a). J. Amer. Vet. Med. Ass. 112, 283–90.Google Scholar
McCulloch, E. C, Hauge, S. & Migaki, H. (1948b). Amer. J. Publ. Hlth. 38, 493–503.CrossRefGoogle Scholar
Miller, C. P. (1942). Amer. J. Publ. Hlth. 49, 197.Google Scholar
Nagel, A. (1940). München. Med. Wschr. 1, 970.Google Scholar
Quisno, R. A. & Foter, M. J. (1946). J. Bact. 52, 111–17.CrossRefGoogle Scholar
Quisno, R. A., Foter, M. J. & Rubenkoenig, H. L. (1947). Soap and San. Chem. 23, 145.Google Scholar
Quisno, R. A., Gibby, I. W. & Foter, M. J. (1946a). J. Amer. Pharm. Ass. 35, 317–19.CrossRefGoogle Scholar
Quisno, R. A., Gibby, I. W. & Foter, M. J. (1946b). Amer. J. Pharm. 118, 320–3.Google Scholar
Valko, E. I. & Du Bois, A. S. (1944). J. Bact. 47 15–25.CrossRefGoogle Scholar