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Rates of Stenotrophomonas maltophilia colonization and infection in relation to antibiotic cycling protocols

  • A. L. PAKYZ (a1) and B. M. FARR (a2)

This study evaluated whether antibiotic cycling programmes using broad-spectrum agents including carbapenems were associated with increased rates of colonization or infection by Stenotrophomonas maltophilia. Retrospective analyses of colonization or infection by S. maltophilia from 1992 to 2002 were conducted using University of Virginia Hospital clinical microbiology records of patients with any culture positive for S. maltophilia and hospital epidemiology records of nosocomial S. maltophilia infections. Incidence rates were calculated and compared for cycling and non-cycling periods. No significant differences were found in incidence rates of S. maltophilia isolates between cycling and non-cycling periods, but there was a significant secular increase in the hospital-wide rate of infections caused by S. maltophilia (P=0·01728). Antibiotic cycling protocols were not associated with a significantly increased rate of colonization of S. maltophilia as determined by the frequency of patients having at least one positive routine clinical culture in this hospital.

Corresponding author
*Author for correspondence: A. L. Pakyz, Pharm.D., M.S., Virginia Commonwealth University, School of Pharmacy, Medical College of Virginia Campus, 410 North 12th Street, PO Box 980583, Richmond, VA 23298, USA. (Email:
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1. DP Raymond , Impact of a rotating empiric antibiotic schedule on infectious mortality in an intensive care unit. Critical Care Medicine 2001; 29: 11011108.

2. TH Dellit , Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America Guidelines for developing an institutional program to enhance antimicrobial stewardship. Clinical Infectious Diseases 2007; 44: 159177.

4. ME Villarino , Risk factors for epidemic Xanthomonas maltophilia/colonization in intensive care unit patients. Infection Control and Hospital Epidemiology 1991; 13: 201206.

5. Y Carmeli , MH Samore . Comparison of treatment with imipenem vs. ceftazidime as a predisposing factor for nosocomial acquisition of Stenotrophomonas maltophilia: a historical cohort study. Clinical Infectious Diseases 1997; 24: 11311134.

7. JS Garner , CDC definitions for nosocomial infections. American Journal of Infection Control 1988; 16: 128140.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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