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The relationship of meteorological conditions to the epidemic activity of respiratory syncytial virus

  • S. YUSUF (a1), G. PIEDIMONTE (a2), A. AUAIS (a2), G. DEMMLER (a3), S. KRISHNAN (a4), P. VAN CAESEELE (a5), R. SINGLETON (a6), S. BROOR (a7), S. PARVEEN (a7), L. AVENDANO (a8), J. PARRA (a8), S. CHAVEZ-BUENO (a9), T. MURGUÍA DE SIERRA (a10), E. A. F. SIMOES (a11), S. SHAHA (a12) and R. WELLIVER (a1)...
Summary
SUMMARY

Our aim was to obtain knowledge of how meteorological conditions affect community epidemics of respiratory syncytial virus (RSV) infection. To this end we recorded year-round RSV activity in nine cities that differ markedly in geographic location and climate. We correlated local weather conditions with weekly or monthly RSV cases. We reviewed similar reports from other areas varying in climate. Weekly RSV activity was related to temperature in a bimodal fashion, with peaks of activity at temperatures above 24–30°C and at 2–6°C. RSV activity was also greatest at 45–65% relative humidity. RSV activity was inversely related to UVB radiance at three sites where this could be tested. At sites with persistently warm temperatures and high humidity, RSV activity was continuous throughout the year, peaking in summer and early autumn. In temperate climates, RSV activity was maximal during winter, correlating with lower temperatures. In areas where temperatures remained colder throughout the year, RSV activity again became nearly continuous. Community activity of RSV is substantial when both ambient temperatures and absolute humidity are very high, perhaps reflecting greater stability of RSV in aerosols. Transmission of RSV in cooler climates is inversely related to temperature possibly as a result of increased stability of the virus in secretions in the colder environment. UVB radiation may inactivate virus in the environment, or influence susceptibility to RSV by altering host resistance.

Copyright
Corresponding author
*Author for correspondence: R. Welliver, Sr., M.D., Women & Children's Hospital of Buffalo – Pediatric Infectious Diseases, 219 Bryant Street, Buffalo, NY 14222, USA. (Email: rwelliver@upa.chob.edu)
References
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1. Leader S, Kohlhase K. Respiratory syncytial virus-coded pediatric hospitalizations, 1997 to 1999. Pediatric Infectious Disease Journal 2002; 21: 629632.
2. Shay DK, et al. Bronchiolitis-associated hospitalizations among US children, 1980–1996. Journal of the American Medical Association 1999; 282: 14401446.
3. Sigurs N, et al. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. American Journal of Respiratory and Critical Care Medicine 2000; 161: 15011507.
4. Denny FW, Clyde WA Jr.. Acute lower respiratory tract infections in nonhospitalized children. Journal of Pediatrics 1986; 108: 635646.
5. Laham FR, et al. Differential production of inflammatory cytokines in primary infection with human metapneumonirus and with other common respiratory viruses of infancy. Journal of Infectious Diseases 2004; 189: 4756.
6. Chew FT, et al. Seasonal trends of viral respiratory tract infections in the tropics. Epidemiology and Infection 1998; 121: 121128.
7. Chan PWK, et al. Seasonal variation in respiratory syncytial virus chest infection in the tropics. Pediatric Pulmonology 2002; 34: 4751.
8. Groothuis JR, et al. Prophylactic administration of respiratory syncytial virus immune globulin to high-risk infants and young children. New England Journal of Medicine 1993; 329: 15241530.
9. The IM-pact-RSV Study Group. Palivizumab, a humanized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants. Pediatrics 1998; 102: 531537.
10. Hall CB, Douglas RG Jr.. Modes of transmission of respiratory syncytial virus. Journal of Pediatrics 1981; 99: 100103.
11. Rechsteiner J, Winkler KC. Inactivation of respiratory syncytial virus in aerosol. Journal of General Virology 1969; 5: 405410.
12. Hambling MH. Survival of the respiratory syncytial virus during storage under various conditions. British Journal of Experimental Pathology 1964; 45: 647655.
13. Wang TT, et al. 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. Journal of Immunology 2004; 173: 29092912.
14. Gombart AF, Luong QT, Koeffler HP. Vitmin D compounds: activity against microbes and cancer. Anticancer Research 2006; 26: 25312542.
15. Liu PT, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006; 311: 17701773.
16. Ganz T. Defensins: antimicrobial peptides of innate immunity. Nature Reviews Immunology 2003; 3: 710720.
17. Daher KA, Selsted ME Lehrere RI. Direct inactivation of viruses by human granulocyte defensins. Journal of Virology 1986; 60: 10681074.
18. Holick MF. Resurrection of vitamin D and rickets. Journal of Clinical Investigation 2006; 116: 20622072.
19. Rehman PK. Sub-clinical rickets and recurrent infection. Journal of Tropical Pediatrics 1994; 40: 58.
20. Cannell JJ, et al. Epidemic influenza and vitamin D. Epidemiology and Infection 2006; 134: 11291140.
21. Cherian T, et al. Bronchiolitis in tropical South India. American Journal of Diseases of Children 1990; 144: 10261030.
22. Gilchrist S, et al. National surveillance for respiratory syncytial virus, United States, 1985–1990. Journal of Infectious Diseases 1994; 170: 986990.
23. Washburne JF, Bocchini JA Jr., Jamison RM. Summertime respiratory syncytial virus infection: epidemiology and clinical manifestations. Southern Medical Journal 1992; 85: 579583.
24. Halstead DC, Jenkins SG. Continuous non-seasonal epidemic of respiratory syncytial virus infection in the Southeast United States. Southern Medical Journal 1998; 91: 433436.
25. Huq F, et al. Acute lower respiratory tract infection due to virus among hospitalized children in Dhaka, Bangladesh. Review of Infectious Diseases 1990; 12 (Suppl. 8): S982S987.
26. Sung RYT, et al. Epidemiology and aetiology of acute bronchiolitis in Hong Kong infants. Epidemiology and Infection 1992; 108: 147154.
27. Mullins JA, et al. Substantial variablilty in community respiratory syncytial virus season timing. Pediatric Infectious Disease Journal 2003; 22: 857862.
28. Welliver RC. Detection, pathogenesis, and therapy of respiratory syncytial virus infections. Clinical Microbiology Reviews 1988; 1: 2739.
29. Barone SR. Rapid diagnosis of infection with respiratory syncytial virus. Report on Pediatric Infectious Diseases 1997; 7: 67.
30. Weber MW, et al. The clinical spectrum of respiratory syncytial virus disease in The Gambia. Pediatric Infectious Disease Journal 1998; 17: 224230.
31. Jamjoom GA, et al. Respiratory syncytial virus infection in young children hospitalized with respiratory illness in Riyadh. Journal of Tropical Pediatrics 1993; 39: 346349.
32. Hijazi Z, et al. Respiratory syncytial virus infections in children in a desert country. Pediatric Infectious Disease Journal 1995; 14: 322324.
33. Florman AL, McLaren LC. The effect of altitude and weather on the occurrence of outbreaks of respiratory syncytial virus infections. Journal of Infectious Diseases 1988; 158: 14011402.
34. Orstavik I, Carlsen K-HC, Halvorsen K. Respiratory syncytial virus infections in Oslo 1972–1978. Acta Paediatrica Scandinavica 1980; 69: 717722.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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