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Risk factors for community-associated Staphylococcus aureus infections: results from parallel studies including methicillin-resistant and methicillin-sensitive S. aureus compared to uninfected controls

  • K. J. COMO-SABETTI (a1), K. H. HARRIMAN (a1), S. K. FRIDKIN (a2), S. L. JAWAHIR (a3) and R. LYNFIELD (a1)
  • DOI:
  • Published online: 01 June 2010

Despite the increasing burden of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections, the risk factors are not well understood. We conducted a hypothesis-generating study using three parallel case-control studies to identify risk factors for CA-MRSA and community-associated methicillin-susceptible S. aureus (CA-MSSA) infections. In the multivariate model, antimicrobial use in the 1–6 months prior to culture was associated with CA-MRSA infection compared to CA-MSSA [adjusted odds ratio (aOR) 1·7, P=0·07] cases. Antimicrobial use 1–6 months prior to culture (aOR 1·8, P=0·04), history of boils (aOR 1·6, P=0·03), and having a household member who was a smoker (aOR 1·3, P=0·05) were associated with CA-MRSA compared to uninfected community controls. The finding of an increased risk of CA-MRSA infection associated with prior antimicrobial use highlights the importance of careful antimicrobial stewardship.

Corresponding author
*Author for correspondence: K. J. Como-Sabetti, M.P.H., Infectious Disease Epidemiology, Prevention and Control, Minnesota Department of Health, Orville L. Freeman Building, 625 Robert St. N, PO Box 64975, St. Paul, MN55164-0975, USA. (Email:
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