Skip to main content
×
×
Home

The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses

  • D. Hobson (a1), R. L. Curry (a1), A. S. Beare (a2) and A. Ward-Gardner (a3)
Summary

The intranasal inoculation of volunteers with living partially attenuated strains of influenza A and B viruses offers a new opportunity to determine the protective effect of serum haemagglutin-inhibiting antibody against a strictly homologous virus, under conditions where the time and dosage of the infective challenge can be controlled, the scoring of proven infections can be more precise and higher rates of infection can be achieved than in most natural epidemics.

In 1032 adult volunteers, whose serum HI antibody titre was determined immediately before virus challenge, there was a consistent inverse quantitative relationship between the HI titre and the likelihood of infection. The PD50 (50 % protective dose) of HI antibody was 1/18–1/36, but an unusual finding was that volunteers with no detectable pre-challenge antibody often seem to be less susceptible to infection than those with pre-challenge antibody in low titre.

In one group of volunteers challenged with an influenza B strain there was no evidence that pre-challenge antibody titres against viral neuraminidase had any significant protective effect against challenge infection.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses
      Available formats
      ×
Copyright
References
Hide All
Allison, A. C. (1965). Genetic factors in resistance against virus infections. Archiv für die gesamte Virusforschung 17, 280.
Bashe, W. J., Stegmuller, H., Leonida, D. & Greenwald, P. (1964). Failure of polyvalent vaccine to provide clinical protection against Asian influenza. New England Journal of Medicine 270, 870.
Beare, A. S., Hobson, D., Reed, S. E. & Tyrrell, D. A. J. (1968). A comparison of live and killed influenza virus vaccines. Lancet ii, 418.
Beare, A. S., Maassab, H. F., Tyrrell, D. A. J., Slepushkin, A. N. & Hall, T. S. (1971). A comparative study of attenuated influenza viruses. Bulletin of the World Health Organisation 44, 593.
Beare, A. S., Tyrrell, D. A. J., Hobson, D., Howells, C. H. L., Pereira, M. S., Pollock, T. M. & Tyler, L. E. (1969). Live influenza B vaccine in volunteers. Journal of Hygiene 67, 1.
Downie, J. C. (1970). Neuraminidase-inhibiting and haemagglutination-inhibiting antibodies in serum and nasal secretion of volunteers immunized with attenuated and inactivated influenza B/Eng/13/65 virus vaccines. Journal of Immunology 105, 620.
Downie, J. C. & Stuart-Harris, C. H. (1970). The production of neutralizing activity in serum and nasal secretion following immunization with influenza B virus. Journal of Hygiene 68, 233.
Easterday, B., Laver, W. G., Pereira, H. G. & Schild, G. C. (1969). Antigenic composition of recombinant virus strains produced from human and avian influenza viruses. Journal of General Virology 5, 83.
Hobson, D., Lane, C. A., Beare, A. S. & Chivers, C. P. (1964). Serological studies on adult volunteers inoculated with oil-adjuvant Asian influenza vaccine. British Medical Journal ii, 271.
Hoyle, L. (1968). The Influenza Viruses, chap. 27. Vienna: Springer-Verlag.
Laver, W. G. (1963). The structure of influenza viruses. 3. Disruption of the virus particle and separation of neuraminidase activity. Virology 20, 251.
Lindenmann, J., Lane, C. A. & Hobson, D. (1963). The resistance of A2G mice to myxoviruses. Journal of Immunology 90, 942.
McDonald, J. C., Zuckermann, A. J., Beare, A. S. & Tyrrell, D. A. J. (1962). Trials of live influenza vaccine in the Royal Air Force. British Medical Journal i, 1036.
McDonald, J. C. & Zuckermann, A. J. (1962). A B O blood groups and acute respiratory virus disease. British Medical Journal ii, 89.
Maynard, J. E., Dull, H. B., Hanson, M. L., Feltz, E. T., Berger, B. & Hammes, L. (1968). Evaluation of monovalent and polyvalent influenza vaccines during an epidemic of Type A2 and B influenza. American Journal of Epidemiology 87, 148.
Meiklejohn, G., Kempe, C. H., Thalman, W. G. & Lennette, E. H. (1952). Evaluation of monovalent influenza vaccines. II. Observations during an influenza A-prime epidemic. American Journal of Hygiene 55, 12.
Potter, C. W. (1969). HI antibody to various influenza viruses and adenoviruses in individuals of blood groups A and O. Journal of Hygiene 67, 67.
Schild, G. C. & Newman, R. W. (1969). Antibody against influenza A2 virus neuraminidase in human sera. Journal of Hygiene 67, 353.
Slepushkin, A. N., Schild, G. C., Beare, A. S., Chinn, S. & Tyrrell, D. A. J. (1971). Anti-neuraminidase antibody and resistance to vaccination with live A2/Hong Kong influenza virus vaccines. Journal of Hygiene 69, 571.
Tyrrell, D. A. J. (1963). The use of volunteers. American Review of Respiratory Diseases 88, Supplement 128.
Webster, R. G. & Laver, W. G. (1967). Preparation and properties of antibody directed specifically against the neuraminidase of influenza virus. Journal of Immunology 99, 49.
World Health Organization (1953). Expert Committee on Influenza. Technical Report Series of the World Health Organization, no. 64.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 78 *
Loading metrics...

Abstract views

Total abstract views: 611 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 22nd August 2018. This data will be updated every 24 hours.