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Routine experience of the mouse-protection assay of pertussis vaccine

Published online by Cambridge University Press:  19 October 2009

J. Ungar  and
B. Basil
J. Ungar
Affiliation:
Glaxo Laboratories, Limited, Greenford, Middlesex
B. Basil
Affiliation:
Glaxo Laboratories, Limited, Greenford, Middlesex
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The mouse-protection test is discussed as a routine procedure. It has been shown that the assay is exceptionally subject to variation and that an average slope of 1·47 has been found over a year. With this slope and tests involving 90–180 mice it is possible tobe reasonably sure that a vaccine actually 3 times as potent as needed passes a test which lays down that the lower fiducial limit (P = 0·95) should exceed the specified requirement. For a vaccine only 1·5 times as potent as needed, much more extensive laboratory work would be necessary.

Type
Research Article
Information
Journal of Hygiene , Volume 55 , Issue 1 , March 1957 , pp. 45 - 49
Copyright
Copyright © Cambridge University Press 1957

References

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