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Serological examination of IgE- and IgG-specific antibodies to egg protein during influenza virus immunization

  • N. Yamane (a1) and H. Uemura (a1)
Summary
SUMMARY

The concentrations of serum IgE (PRIST) and IgE- and IgG-specific antibodies to egg protein were determined in paired sera taken from students who had received influenza virus vaccine. Although persons who gave a history of allergy to egg or to chicken feathers were excluded, 10–16% of vaccinees possessed higher titres of serum IgE and IgE-specific antibody (RAST) to egg white (Fl) allergen before vaccination. The titres of IgG-specific antibody to egg protein (ovalbumin and ovomucoid antigens) were negligible, and did not show any significant response after vaccination. In contrast, IgE-specific antibody to Fl allergen rose significantly in a considerable number of the vaccinccs. The results obtained indicate possible contamination of vaccine products with allergens of egg origin and a potential risk of allergic manifestation after influenza vaccination.

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References
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Davies R. & Pepys J. (1976). Egg allergy, influenza vaccine, and immunoglobulin-E antibody. Journal of Allergy and Clinical Immunology 57, 373378.
Francis T. Jr (1967). Epidemic influenza: immunization and control. Medical Clinics of North America 51, 781790.
Hosoi S., Shinomiya K., Nakano H., Mikawa H. & Harada S. (1985). Monoclonal antihuman IgG antibodies for quantitation of allergen-specific IgG in human sera. Journal of Allergy and Clinical Immunology 75, 320327.
Ishizaka K. & Ishizaka T. (1967). Identification of γE-antibodies as a carrier of reaginic activity. Journal of Immunology 99, 11871198.
Ishizaka K. & Ishizaka T. (1968). Human reaginic antibodies and immunoglobulin E. Journal of Allergy 42, 330363.
Kawashima H. (1986). Study on contaminated antigen in purified mumps virus antigen from allantoic fluids of hens' eggs for enzyme-linked immunosorbent assay (ELISA). Journal of the Japanese Association for Infectious Diseases 60, 257266.
Parish W. E. (1970). Short-term anaphylactic IgG antibodies in human sera. Lancet ii, 591592.
Shioda H., Mishima K., Kohno S., Horiuchi K., Tomita Y., Muramatsu Y., Itakura Y., Arai Y., Joh M., Tanaka A., Kubo M. & Takahashi K. (1973). Allergy and vaccination. Pediatric Examination 36, 530539.
Tsuji M., Sasaki K., Nakagawa M., Mori T., Nakayama T., Makino S. & Okamura M. (1983). Improved enzyme-linked immunosorbent assay (ELISA) for the detection of mumps virus antibodies Kitasato Archives of Experimental Medicine 56, 137147.
Tsunoda A., Kumasaka M., Takai S. & Shibazaki K. (1980). The adverse reactions associated with the HA influenza vaccine. Clinical Virology 8, 4951.
Yamane N., Hiratsuka M., Arikawa J., Odagiri T. & Ishida N. (1981). Antibody responses after repeated influenza A virus immunizations among schoolchildren in Japan. Journal of Hygiene 87, 383392.
Yamane N., Nakamura Y., Yuki M., Odagiri T. & Ishida N. (1984). Serological evaluation of an influenza A virus cold-adapted reassortmant live vaccine, CR-37(H1N1), in Japanese adult volunteers. Journal of Hygiene 92, 231242.
Yamane N. & Uemura H. (1986). Enzyme-linked immunosorbent assay to quantify IgG antibody specific to Dermatophagoides pteronyssinus. Clinical Allergy 6, 230237.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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