Skip to main content
×
Home
    • Aa
    • Aa

The seroprevalance of Crimean-Congo haemorrhagic fever in people living in the same environment with Crimean-Congo haemorrhagic fever patients in an endemic region in Turkey

  • I. KOKSAL (a1), G. YILMAZ (a1), F. AKSOY (a1), S. ERENSOY (a1) and H. AYDIN (a1)...
Abstract
SUMMARY

Crimean-Congo haemorrhagic fever (CCHF) is endemic in Turkey, and since 2004 many cases have been reported from different regions of Turkey. There are limited data about the seroprevalence of the disease in household members of patients or persons sharing the same environment. We evaluated seroprevalence of CCHF in the immediate neighbourhood and in household members of patients living in the same environment as confirmed cases of CCHF in an endemic area of Turkey. A total of 625 healthy subjects [mean (s.d.) age: 42·3 (18·4) years, 58·7% females] without a past history of CCHF infection included in this case-control, retrospective study were evaluated in terms of sociodemographic characteristics, risk factors for CCHF via a study questionnaire, while serum analysis for CCHF virus (CCHFV) IgG antibodies was performed by ELISA. Anti-CCHFV IgG antibodies were positive in 85 (13·6%) participants. None of the seropositive individuals had a history of symptomatic infection. Regression analysis revealed that animal husbandry [odds ratio (OR) 1·84, 95% confidence interval (CI) 1·09–3·11], contact with animals (OR 2·31, 95% CI 1·08–5·10), contact with ticks (OR 3·45, 95% CI 1·87–6·46), removing ticks from animals by hand (OR 2·48, 95% CI 1·48–4·18) and living in a rural area (OR 4·05, 95% CI 1·65–10·56) were associated with increased odds of having IgG seropositivity, while being a household member of a patient with prior CCHF infection had no influence on seropositivity rates. This result also supports the idea that CCHF is not transmitted person-to-person by the airborne route.

Copyright
Corresponding author
*Author for correspondence: Professor I. Koksal, Karadeniz Technical University Medical Faculty, Infectious Diseases and Clinical Microbiology Department, Trabzon, Turkey. (Email: iftihar@yahoo.com)
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

3. M Saijo , S Morikawa , I Kurane . Recent progress in the treatment for Crimean-Congo haemorrhagic fever and future perspectives. Future Virology 2010; 5: 801809.

4. P Sidira , Seroepidemiological study of Crimean-Congo haemorrhagic fever in Greece, 2009–2010. Clinical Microbiology and Infection 2012; 18: E1619.

9. S Chinikar , Crimean-Congo haemorrhagic fever in Iran and neighboring countries. Journal of Clinical Virology 2010; 47: 110114.

11. I Gergova , M Kunchev , B Kamarinchev . Crimean-Congo haemorrhagic fever virustick survey in endemic areas in Bulgaria. Journal of Medical Virology 2012; 84: 608614.

12. H Bodur , Subclinical infections with Crimean-Congo haemorrhagic fever virus, Turkey. Emerging Infectious Diseases 2012; 18: 640642.

13. S Izadi , Crimean-Congo haemorrhagic fever in Sistan and Baluchestan Province of Iran, a case-control study on epidemiological characteristics. International Journal of Infectious Diseases 2004; 8: 299306.

15. RJ Williams , Crimean-congo haemorrhagic fever: a seroepidemiological and tick survey in the Sultanate of Oman. Tropical Medicine and International Health 2000; 5: 99106.

17. CC Mathiot , Antibodies to haemorrhagic fever viruses in Madagascar populations. Transactions of the Royal Society Tropical Medicine and Hygiene 1989; 83: 407409.

19. O Ergonul , Zoonotic infections among veterinarians in Turkey: Crimean-Congo haemorrhagic fever and beyond. International Journal of Infectious Diseases 2006; 10: 465469.

20. O Ergonul , The lack of Crimean-Congo haemorrhagic fever virus antibodies in healthcare workers in an endemic region. International Journal of Infectious Diseases 2007; 11: 4851.

22. B Ertugrul , The seroprevalence of Crimean-Congo haemorrhagic fever among inhabitants living in the endemic regions of Western Anatolia. Scandinavian Journal of Infectious Diseases 2012; 44: 276281.

23. Z Vatansever , Crimean-Congo haemorrhagic fever in Turkey. In: O Ergonul , CA Whitehouse , eds. Crimean-Congo Haemorrhagic Fever: A Global Perspective. Amsterdam: Springer, 2007, pp. 5974.

24. I Koksal , The efficacy of ribavirin in the treatment of Crimean-Congo haemorrhagic fever in Eastern Black Sea region in Turkey. Journal of Clinical Virology 2010; 47: 6568.

27. A Tarantola , E Ergonul , P Tattevin . Estimates and prevention of Crimean Congo haemorrhagic fever risks for health-care workers. In: O Ergonul , CA Whithouse , eds. Crimean-Congo Haemorrhagic Fever: A Global Perspective. Amsterdam: Springer, 2007, pp. 281294.

29. MA Cevik , Viral load as a predictor of outcome in Crimean-Congo haemorrhagic fever. Clinical Infectious Diseases 2007; 45: 96100.

30. A Saksida , Interacting roles of immune mechanisms and viral load in the pathogenesis of Crimean-Congo haemorrhagic fever. Clinical and Vaccine Immunology 2010; 17: 10861093.

31. MA Cevik , Clinical and laboratory features of Crimean-Congo haemorrhagic fever: predictors of fatality. International Journal of Infectious Diseases 2008; 12: 374379.

32. R Vorou , IN Pierroutsakos , HC Maltezou . Crimean-Congo haemorrhagic fever. Current Opinion in Infectious Diseases 2007; 20: 495500.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 1
Total number of PDF views: 9 *
Loading metrics...

Abstract views

Total abstract views: 155 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 23rd May 2017. This data will be updated every 24 hours.