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Skin reactivity and antibody response following vaccination against smallpox

Published online by Cambridge University Press:  15 May 2009

A. L. Terzin ,
B. Vuković ,
V. Mudrić  and
A. Banković
A. L. Terzin
Affiliation:
Medical Faculty and Institute of Public Health, Novi Sad, Yugoslavia
B. Vuković
Affiliation:
Medical Faculty and Institute of Public Health, Novi Sad, Yugoslavia
V. Mudrić
Affiliation:
Medical Faculty and Institute of Public Health, Novi Sad, Yugoslavia
A. Banković
Affiliation:
Medical Faculty and Institute of Public Health, Novi Sad, Yugoslavia
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Summary

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Revaccination between 2 and 5 years after the last vaccination induced higher complement-fixation titres than revaccination 7–63 years after the last vaccination. The highest CF titres were reached during the 3rd to the 5th week after vaccination.

Fifty-two serum samples, taken 137 or more days after a successful vaccination, all showed CF titres lower than 1/2.

In a group of successfully vaccinated persons with no post-vaccinal complications, 65 out of 66 had a successful ‘take’ after one or two subsequent vaccinations.

Sera of persons receiving primary vaccination showed significantly lower CF titres than sera of revaccinated persons. Cases of post-vaccinal encephalitis showed greater antibody response than uncomplicated successfully vaccinated cases in both the primary vaccination and revaccination groups. The antibody response in revaccinated persons with post-vaccinal encephalitis was greater than that in the group of successfully revaccinated cases without encephalitis.

A group of 26 naturally hyporeactive persons completely failed to ‘take’ even after vaccination repeated between 3 and 10 times (average 5 times per person). The frequency of seropositives in this group, and the height of their CF titres, were significantly lower than in the group of successfully vaccinated persons. These findings support the view that untreated persons who repeatedly fail to ‘take’ with the vaccine must not be considered immune.

In vaccinated persons treated with immunoglobulin (with or without simultaneous treatment with Marboran) antibody production was apparently diminished. Treatment of patients with Marboran significantly lowers the capacity of the vaccine to ‘take’.

Type
Research Article
Information
Journal of Hygiene , Volume 72 , Issue 2 , April 1974 , pp. 173 - 180
Copyright
Copyright © Cambridge University Press 1974

References

REFERENCES

Chambers, E. G. (1952). Statistical Calculations for Beginners. Cambridge University Press.Google Scholar
Diem, K. (1960). Mathematische und statistische Tabellen. In Documenta Geigy, Wissen-schaftliche Tabellen. Basle: J. R. Geigy A.G.Google Scholar
Dixon, C. W. (1962). Smallpox. London: J. and A. Churchill Ltd.Google Scholar
Downie, A. W. (1965). Poxvirus group. In Horsfall, F. L. Jr. and Tam, I.: Viral and Rickettsial Infections of Man. Philadelphia, Toronto: J. B. Lippincott Co.Google Scholar
McCarthy, K., Downie, A. W. & Bradley, W. H. (1958). The antibody response in man following infection with viruses of the pox group. II. Antibody response following vaccination. Journal of Hygiene 56, 466–78.Google ScholarPubMed
Terzin, A. L., Bordjoški, M. N., Milovanović, M. V., Stojković, LJ. V. & Dimić, M. M. (1954). Some viral, rickettsial and leptospiral infections diagnosed in Serbia. Journal of Hygiene 52, 129–50.CrossRefGoogle ScholarPubMed
Terzin, A. L., Mašić, M., Vuković, B. & Mudrić, V. (1974). A virological study of postvaccinal encephalitis. Journal of Hygiene 72, 169–72.CrossRefGoogle Scholar
van Rooyen, C. E. & Rhodes, A. J. (1948). Virus Diseases of Man. New York: Thomas Nelson and Sons.Google Scholar