Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 9
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    2013. Mollison's Blood Transfusion in Clinical Medicine.


    Smyth, E. C. Capanu, M. Janjigian, Y. Y. Kelsen, D. K. Coit, D. Strong, V. E. and Shah, M. A. 2012. Tobacco Use Is Associated with Increased Recurrence and Death from Gastric Cancer. Annals of Surgical Oncology, Vol. 19, Issue. 7, p. 2088.


    Fock, K Ming Katelaris, Peter Sugano, Kentaro Ang, Tiing Leong Hunt, Richard Talley, Nicholas J Lam, Shiu Kum Xiao, Shu-Dong Tan, Huck Joo Wu, Chun-Ying Jung, Hyun Chae Hoang, Bui Huu Kachintorn, Udom Goh, Khean-Lee Chiba, Tsutomu and Rani, Abdul Aziz 2009. Second Asia-Pacific Consensus Guidelines forHelicobacter pyloriinfection. Journal of Gastroenterology and Hepatology, Vol. 24, Issue. 10, p. 1587.


    Suzuki, Takeshi Matsuo, Keitaro Ito, Hidemi Sawaki, Akira Hirose, Kaoru Wakai, Kenji Sato, Shigeki Nakamura, Tsuneya Yamao, Kenji Ueda, Ryuzo and Tajima, Kazuo 2006. Smoking Increases the Treatment Failure for Helicobacter pylori Eradication. The American Journal of Medicine, Vol. 119, Issue. 3, p. 217.


    Tsukada, Katsuhiko Katoh, Hiroyuki Miyazaki, Tatsuya Fukuchi, Minoru Kuwano, Hiroyuki Kimura, Hitoshi Fukai, Yasuyuki Inose, Takanori Motojima, Teiji Toda, Naotaka and Yamada, Shuji 2006. Factors Associated with the Development of Reflux Esophagitis After Helicobacter pylori Eradication. Digestive Diseases and Sciences, Vol. 51, Issue. 3, p. 539.


    Masaoka, T. Suzuki, H. Kamiya, A. G. and Ishii, H. 2004. Second-line treatment of Helicobacter pylori infection after dilution agar methods and PCR-RFLP analysis. Alimentary Pharmacology and Therapeutics, Vol. 20, Issue. s1, p. 68.


    McLoughlin, Ramona Racz, Istvan Buckley, Martin O'Connor, Humphrey J. and O'Morain, Colm 2004. Therapy of Helicobacter pylori. Helicobacter, Vol. 9, Issue. s1, p. 42.


    Wu, William K.K. and Cho, Chi Hin 2004. The Pharmacological Actions of Nicotine on the Gastrointestinal Tract. Journal of Pharmacological Sciences, Vol. 94, Issue. 4, p. 348.


    Zullo, Angelo Hassan, Cesare Campo, Salvatore MA and Morini, Sergio 2004. Evolving therapy for Helicobacter pylori infection. Expert Opinion on Therapeutic Patents, Vol. 14, Issue. 10, p. 1453.


    ×

Smoking and polymorphisms of fucosyltransferase gene Le affect success of H. pylori eradication with lansoprazole, amoxicillin, and clarithromycin

  • K. MATSUO (a1) (a2), N. HAMAJIMA (a1), Y. IKEHARA (a3), T. SUZUKI (a4), T. NAKAMURA (a4), A. MATSUURA (a4), K. TAJIMA (a1) and S. TOMINAGA (a5)
  • DOI: http://dx.doi.org/10.1017/S0950268802008129
  • Published online: 01 April 2003
Abstract

Identification of factors influencing success of Helicobacter pylori (HP) eradication is important for clinical practice. We have prospectively conducted an HP eradication study in the Aichi Cancer Center with a total of 142 patients available for analysis. The overall success rate was 61·3% (95% confidence interval 52·7–69·3%). Smoking during the medication for eradication significantly decreased the success rate (42·9%), whereas smoking cessation during the treatment was associated with a similar rate as for non-smokers (66·7%). We also examined links between an eradication outcome and polymorphisms of Le, Se, IL1A, IL1B, IL1RN and MPO genes, but with one exception none showed any association. The non-functional le allele of Le polymorphisms, leading to decreased expression of Leb antigen to which HP attaches with adhesin, showed a beneficial effect for success. Although further clarification is necessary, our study indicated that smoking cessation and Le gene polymorphisms may affect the success rate of HP eradication.

Copyright
Corresponding author
Author for correspondence: Division of Epidemiology and Prevention, 1-1 Kanokoden, Chikusa-ku, Nagoya, Japan 464-8681.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×