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Spatial and temporal patterns in antimicrobial resistance of Salmonella Typhimurium in cattle in England and Wales

  • R. COX (a1) (a2), T. SU (a3), H. CLOUGH (a1), M. J. WOODWARD (a4) and C. SHERLOCK (a1) (a3)...

Salmonella is the second most commonly reported human foodborne pathogen in England and Wales, and antimicrobial-resistant strains of Salmonella are an increasing problem in both human and veterinary medicine. In this work we used a generalized linear spatial model to estimate the spatial and temporal patterns of antimicrobial resistance in Salmonella Typhimurium in England and Wales. Of the antimicrobials considered we found a common peak in the probability that an S. Typhimurium incident will show resistance to a given antimicrobial in late spring and in mid to late autumn; however, for one of the antimicrobials (streptomycin) there was a sharp drop, over the last 18 months of the period of investigation, in the probability of resistance. We also found a higher probability of resistance in North Wales which is consistent across the antimicrobials considered. This information contributes to our understanding of the epidemiology of antimicrobial resistance in Salmonella.

Corresponding author
*Author for correspondence: Dr R. Cox, Centre for Veterinary Epidemiological Research, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada. (Email:
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4. EJ Threlfall , A comparison of antimicrobial susceptibilities in nontyphoidal Salmonellas from humans and food animals in England and Wales in 2000. Microbial Drug Resistance 2003; 9: 183189.

6. A Meakins , Antimicrobial drug resistance in human nontyphoidal Salmonella isolates in Europe 2000–2004: a report from the Enter-net international surveillance network. Microbial Drug Resistance 2008; 14: 3135.

12. JK Varma , Hospitalization and antimicrobial resistance in Salmonella outbreaks, 1984–2002. Emerging Infectious Diseases 2005; 11: 943946.

15. EJ Threlfall , The emergence and spread of antibiotic resistance in food-borne bacteria. International Journal of Food Microbiology 2000; 62: 15.

16. LD Warnick , Risk factors for clinical salmonellosis in Virginia, USA cattle herds. Preventive Veterinary Medicine 2001; 49: 259275.

18. C Lanzas , Transmission dynamics of a multidrug-resistant Salmonella Typhimurium outbreak in a dairy farm. Foodborne Pathogens and Disease 2010; 7: 467474.

20. CJ Murray . Environmental aspects of Salmonella. In: C Wray , A Wray , eds. Salmonella in Domestic Animals. Wallingford: CABI Publishing, 2000, pp. 265284.

28. SE Robinson , RM Christley . Identifying temporal variation in reported births, deaths and movements of cattle in Britain. BMC Veterinary Research 2006; 2.

30. SA McEwen , PJ Fedorka-Cray . Antimicrobial use and resistance in animals. Clinical Infectious Diseases 2002; 34: S93–106.

36. C Baker-Austin , Co-selection of antibiotic and metal resistance. Trends in Microbiology 2006; 14: 176182.

37. LP Randall , Antibiotic resistance genes, integrons and multiple antibiotic resistance in thirty-five serotypes of Salmonella enterica isolated from humans and animals in the UK. Journal of Antimicrobial Chemotherapy 2004; 53: 208216.

38. M Davis , Feedstuffs as a vehicle of cattle exposure to Escherichia coli O157:H7 and Salmonella enterica. Veterinary Microbiology 2003; 95: 199210.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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