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Spatial and temporal patterns in antimicrobial resistance of Salmonella Typhimurium in cattle in England and Wales

  • R. COX (a1) (a2), T. SU (a3), H. CLOUGH (a1), M. J. WOODWARD (a4) and C. SHERLOCK (a1) (a3)...

Salmonella is the second most commonly reported human foodborne pathogen in England and Wales, and antimicrobial-resistant strains of Salmonella are an increasing problem in both human and veterinary medicine. In this work we used a generalized linear spatial model to estimate the spatial and temporal patterns of antimicrobial resistance in Salmonella Typhimurium in England and Wales. Of the antimicrobials considered we found a common peak in the probability that an S. Typhimurium incident will show resistance to a given antimicrobial in late spring and in mid to late autumn; however, for one of the antimicrobials (streptomycin) there was a sharp drop, over the last 18 months of the period of investigation, in the probability of resistance. We also found a higher probability of resistance in North Wales which is consistent across the antimicrobials considered. This information contributes to our understanding of the epidemiology of antimicrobial resistance in Salmonella.

Corresponding author
*Author for correspondence: Dr R. Cox, Centre for Veterinary Epidemiological Research, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada. (Email:
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1. Department for Environment Food and Rural Affairs. Salmonellosis (Salmonella species). In: Zoonoses Report UK 2009 . London, 2009, pp. 121.
2. Health Protection Agency. Salmonella ( Accessed June 2011.
3. ThrelfallEJ. Antimicrobial drug resistance in Salmonella: problems and perspectives in food- and water-borne infections. Microbiology Reviews 2002; 26: 141148.
4. ThrelfallEJ, et al. A comparison of antimicrobial susceptibilities in nontyphoidal Salmonellas from humans and food animals in England and Wales in 2000. Microbial Drug Resistance 2003; 9: 183189.
5. Department for Environment Food and Rural Affairs. Salmonella in livestock production in Great Britain. Weybridge: Veterinary Laboratories Agency, 2005, pp. 1168.
6. MeakinsA, et al. Antimicrobial drug resistance in human nontyphoidal Salmonella isolates in Europe 2000–2004: a report from the Enter-net international surveillance network. Microbial Drug Resistance 2008; 14: 3135.
7. MillerGY, McNamaraPE, SingerRS. Stakeholder position paper: Economist's perspectives on antibiotic use in animals. Preventive Veterinary Medicine 2006; 73: 163168.
8. SmithBP. Salmonellosis in ruminants. In: SmithBP, ed. Large Animal Internal Medicine , 4th edn. St Louis: Mosby, 2008, pp. 877880.
9. MolbakK, et al. An outbreak of multidrug-resistant, quinolone-resistant Salmonella enterica serotype Typhimurium DT104. New England Journal of Medicine 1999; 341: 14201425.
10. FrenzenPD, et al. Salmonella cost estimate updated using FoodNet data. Food Review 1999; 22: 1015.
11. World Health Organization. Joint FAO/OIE/WHO expert workshop on non-human antimicrobial usage and antimicrobial resistance: scientific assessment. Geneva, Switzerland, 2004, pp. 15.
12. VarmaJK, et al. Hospitalization and antimicrobial resistance in Salmonella outbreaks, 1984–2002. Emerging Infectious Diseases 2005; 11: 943946.
13. HelmsM, et al. Excess mortality associated with antimicrobial drug-resistant Salmonella Typhimurium. Emerging Infectious Diseases 2002; 8: 490495.
14. PrescottJF. Antimicrobial drug resistance and its epidemiology. In: PrescottJF, BaggotJD, WalkerRD, eds. Antimicrobial Therapy in Veterinary Medicine . Ames, IA, USA: Iowa State University Press, 2000, pp. 2749.
15. ThrelfallEJ, et al. The emergence and spread of antibiotic resistance in food-borne bacteria. International Journal of Food Microbiology 2000; 62: 15.
16. WarnickLD, et al. Risk factors for clinical salmonellosis in Virginia, USA cattle herds. Preventive Veterinary Medicine 2001; 49: 259275.
17. PangloliP, et al. Seasonal incidence and molecular characterization of Salmonella from dairy cows, calves, and farm environment. Foodborne Pathogens and Disease 2008; 5: 8796.
18. LanzasC, et al. Transmission dynamics of a multidrug-resistant Salmonella Typhimurium outbreak in a dairy farm. Foodborne Pathogens and Disease 2010; 7: 467474.
19. DigglePJ. Statistical Analysis of Spatial Point Patterns, 2nd edn. Oxford, UK: Hodder Arnold, 2003.
20. MurrayCJ. Environmental aspects of Salmonella. In: WrayC, WrayA, eds. Salmonella in Domestic Animals . Wallingford: CABI Publishing, 2000, pp. 265284.
21. FentonS, et al. Spatial and spatio-temporal analysis of Salmonella infection in dairy herds in England and Wales. Epidemiology and Infection 2009; 137: 847857.
22. GibbensJC, et al. Use of laboratory data to reduce the time taken to detect new diseases: VIDA to FarmFile. Veterinary Record 2008; 162: 771776.
23. DavisonHC, et al. Prevalence, incidence and geographical distribution of serovars of Salmonella on dairy farms in England and Wales. Veterinary Record 2005; 157: 703711.
24. HastieTJ, TibshiraniRJ. Generalized Additive Models: Chapman and Hall/CRC (Monographs on Statistics and Applied Probability), 1987, pp. 352.
25. DigglePJ, RibeiroPJJr.. Model-based Geostatistics. New York: Springer, 2007.
26. MichelP, et al. Regional, seasonal, and antimicrobial resistance distribution of Salmonella Typhimurium in Canada. Canadian Journal of Public Health 2006; 97: 470474.
27. BatemanKG. Antimicrobial drug use in cattle. In: PrescottJF, BaggotJD, WalkerRD, eds. Antimicrobial Therapy in Veterinary Medicine . Ames, IA, USA: Iowa State University Press, 2000, pp. 576590.
28. RobinsonSE, ChristleyRM. Identifying temporal variation in reported births, deaths and movements of cattle in Britain. BMC Veterinary Research 2006; 2.
29. Department for Environment Food and Rural Affairs. The cattle book 2008. Descriptive statistics of cattle numbers in Great Britain on 1 June 2008. Defra, 2008.
30. McEwenSA, Fedorka-CrayPJ. Antimicrobial use and resistance in animals. Clinical Infectious Diseases 2002; 34: S93–106.
31. WegenerHC. Antibiotics in animal feed and their role in resistance development. Current Opinion in Microbiology 2003; 6: 439445.
32. BywaterR, et al. The susceptibility to growth-promoting antibiotics of Entercoccus faecium isolates from pigs and chickens in Europe. Journal of Antimicrobial Chemotherapy 2005; 56: 11391143.
33. BywaterR, et al. A European survey of antimicrobial susceptibility among zoonotic and commensal bacteria isolated from food-producing animals. Journal of Antimicrobial Chemotherapy 2004; 54: 744754.
34. Department for Environment Food and Rural Affairs. Land use and livestock ( Accessed 18 March 2010.
35. Department for Environment Food and Rural Affairs. Salmonella in livestock production in Great Britain. Weybridge: Veterinary Laboratories Agency, 2008, pp. 1168.
36. Baker-AustinC, et al. Co-selection of antibiotic and metal resistance. Trends in Microbiology 2006; 14: 176182.
37. RandallLP, et al. Antibiotic resistance genes, integrons and multiple antibiotic resistance in thirty-five serotypes of Salmonella enterica isolated from humans and animals in the UK. Journal of Antimicrobial Chemotherapy 2004; 53: 208216.
38. DavisM, et al. Feedstuffs as a vehicle of cattle exposure to Escherichia coli O157:H7 and Salmonella enterica . Veterinary Microbiology 2003; 95: 199210.
39. DavisonHC, et al. Risk factors associated with the Salmonella status of dairy farms in England and Wales. Veterinary Record 2006; 159: 871880.
40. EvansSJ. A case control study of multiple resistant Salmonella Typhimurium DT104 infection of cattle in Great Britain. Cattle Practice 1996; 4: 259266.
41. WilsonSJ, et al. Nontyphoidal Salmonellae in United Kingdom Badgers: Prevalence and spatial distribution. Applied and Environmental Microbiology 2003; 69: 43124315.
42. RobinsonSE, ChristleyRM. Exploring the role of auction markets in cattle movements within Great Britain. Preventive Veterinary Medicine 2007; 81: 2137.
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