Hostname: page-component-848d4c4894-v5vhk Total loading time: 0 Render date: 2024-06-17T00:16:54.015Z Has data issue: false hasContentIssue false
  • English
  • Français

Specificity of early protective responses induced by pseudomonas vaccines

Published online by Cambridge University Press:  15 May 2009

R. J. Jones
R. J. Jones
Affiliation:
MRC Industrial Injuries and Burns Unit, Birmingham Accident Hospital, Bath Row, Birmingham B15 1NA
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A single inoculation of pseudomonas vaccine protected mice against a 1 LD 100 challenge by nine different serotypes of Pseudomonas aeruginosa, 4 days after vaccination. Three inoculations of the same vaccine, given on consecutive days, protected mice for a longer time, against challenge by a wide range of Ps. aeruginosa serotypes, than the single inoculation of vaccine. The amount of vaccine inoculated only marginally influenced the non-specific response. F1 vaccines from eight serotypes of Ps. aeruginosa each induced protection against a different range of serotypes.

Type
Research Article
Information
Journal of Hygiene , Volume 70 , Issue 2 , June 1972 , pp. 343 - 351
Copyright
Copyright © Cambridge University Press 1972

References

REFERENCES

Alexander, J. W., Fisher, M. W., MacMillan, B. G. & Altemeier, W. A. (1969). Prevention of invasive pseudomonas infection in burns with a new vaccine. Archives of Surgery 99, 249.CrossRefGoogle ScholarPubMed
Carney, S. A. & Jones, R. J. (1968). Biological and immunochemical properties of culture filtrates of virulent and avirulent strains of Pseudomonas aeruginosa. British Journal of Experimental Pathology 49, 395.Google ScholarPubMed
Cason, J. & Lowbury, E. J. L. (1968). Mortality and infection in extensively burned patients treated with silver nitrate compresses. Lancet i, 651.Google Scholar
Feller, I. (1966). Research in Burns (ed. Wallace, A. B. and Wilkinson, A. W.), p. 470. Edinburgh: Livingstone.Google Scholar
Fisher, H. W., Devlin, H. B. & Gnabasik, F. J. (1969). A new immunotype schema for Pseudomonas aeruginosa based on protective antigen. Journal of Bacteriology 98, 835.Google Scholar
Jones, R. J., Jackson, D. M. & Lowbury, E. J. L. (1966). Antiserum and antibiotic in the prophylaxis of burns against Pseudomonas aeruginosa. British Journal of Plastic Surgery 19, 43.CrossRefGoogle ScholarPubMed
Jones, R. J. (1969 a). Detoxification of an immunogenic fraction from a culture filtrate of Pseudomonas aeruginosa. Journal of Hygiene 67, 241.Google Scholar
Jones, R. J. (1969 b). Pharmacological Treatment of Burns (ed. Bertelli, A.), p. 301. Excerpta Medica International Congress Series, no. 90.Google Scholar
Jones, R. J. (1971). Passive protection of mice against Pseudomonas aeruginosa by serum from recently vaccinated mice. British Journal of Experimental Pathology 52, 100.Google Scholar
Kefalides, W. A., Aran, J. A., Bazan, A., Verlande, N. & Rosenthal, S. M. (1964). Evaluation of antibiotic prophylaxis and gammaglobulin, plasma, albumin, and saline solution therapy in severe burns. Annals of Surgery 159, 496.Google Scholar
Lindberg, R. E., Moncrief, J. A., Switzer, W. E., Order, S. E. & Mills, W. (1965). The successful control of burn wound sepsis. Journal of Trauma 5, 601.Google ScholarPubMed
Lowbury, E. J. L. & Jackson, D. M. (1970). Further trials of chemoprophylaxis for burns. Injury 1, 204.CrossRefGoogle Scholar
Markley, K. & Smallman, E. (1968). Protection by vaccination against Pseudomonas aeruginosa infection after thermal injury. Journal of Bacteriology 96, 867.CrossRefGoogle ScholarPubMed
Tumbusch, W. J., Vogel, E. H., Butkiewicz, J. V., Grabar, C. D., Larson, D. L. & Mitchell, E. T. (1961). Septicaemia in burn injury. Journal of Trauma 1, 22.Google Scholar