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Studies on immunization by a species antigen: III. The presence of an anti-immunity factor in Pneumococcus
Published online by Cambridge University Press: 15 May 2009
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The bodies of pneumococci contain a constituent of protein origin which interferes with immunization.
This constituent can not only counteract the immunizing action of the species antigen, but reduce the immunity response to the type-specific antigen.
In heat-killed pneumococci (ordinary bacterial vaccine) the coagulation of the protein renders the anti-immunity factor relatively insoluble and minimizes its action.
In solutions of pneumococci the anti-immunity factor is liberated and reduces the immunity response to the type-specific antigen.
The immunizing effect of a small dose of heat-killed pneumococci can be abolished if the cocci be dissolved before injection. But a larger dose of dissolved vaccine produces immunity, the effect of the antigen predominating.
The anti-immunity factor is heat resistant at acid pH, but is destroyed by alkaline heat. In these respects it resembles the immunizing antigens.
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References
REFERENCES
Day, H. B. (1942). Studies on immunization by a species antigen. I. Preparation of species antigen from pneumococci. J. Hyg., Camb., 42, 532–46.Google ScholarPubMed
Day, H. B. (1943). Studies on immunization by a species antigen. II. The presence of species antigen and of opposition factor in bacteria other than pneumococci. J. Hyg., Camb., 43, 330–6.Google Scholar
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