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Surveillance of antibiotic susceptibility of Enterobacteriaceae isolated from urine samples collected from community patients in a large metropolitan area, 2010–2012

  • C. S. HORNER (a1) (a2), N. ABBERLEY (a1), M. DENTON (a1) (a2) and M. H. WILCOX (a1) (a2)
Abstract
SUMMARY

Antibiotic susceptibilities of large cohorts of Enterobacteriaceae isolated from urine collected in the community are scarce. We report the susceptibilities of Enterobacteriaceae isolated from urine of non-selected community populations in a metropolitan area (Leeds and Bradford, UK) over 2 years. Isolates (n = 6614) were identified as follows: Escherichia coli (n = 5436), Klebsiella spp. (n = 525), Proteus mirabilis (n = 305), and 15 other species (n = 290); 58 isolates were unidentified. Ampicillin resistance was observed in 53% E. coli and 28% P. mirabilis; ⩾34% E. coli and P. mirabilis were non-susceptible to trimethoprim compared to 20% Klebsiella spp.; nitrofurantoin resistance was observed in 3% E. coli and 15% Klebsiella spp. The occurrence of extended-spectrum β-lactamases (ESBL) was low (6%), as was non-susceptibility to carbapenems, cefipime and tigecycline (<2%). Further surveillance is required to monitor this level of resistance and additional clinical studies are needed to understand the impact on the outcome of current empirical prescribing decisions.

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Corresponding author
*Author for correspondence: Dr C. S. Horner, Leeds Teaching Hospitals NHS Trust, Department of Microbiology, Old Medical School, Leeds General Infirmary, Leeds, UK. (Email: carolyne.horner@leedsth.nhs.uk)
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1. B Foxman . The epidemiology of urinary tract infection. Nature Reviews Urology 2010; 7: 653660.

2. N Woodford , Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. Antimicrobial Agents and Chemotherapy 2009; 53: 44724482.

5. GM Rossolini , MM D'Andrea , C Mugnaioli . The spread of CTX-M-type extended-spectrum beta-lactamases. Clinical Microbiology and Infection 2008; 14 (Suppl. 1): 3341.

9. DM Livermore , Non-susceptibility trends among Enterobacteriaceae from bacteraemias in the UK and Ireland, 2001–06. Journal of Antimicrobial Chemotherapy 2008; 62 (Suppl. 2): ii41ii54.

15. S Hillier , When do general practitioners request urine specimens for microbiology analysis? The applicability of antibiotic resistance surveillance based on routinely collected data. Journal of Antimicrobial Chemotherapy 2006; 58: 13031306.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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