Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 21
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Djidjou Demasse, Ramses Tewa, Jean-Jules Bowong, Samuel and Emvudu, Yves 2016. Optimal control for an age-structured model for the transmission of hepatitis B. Journal of Mathematical Biology, Vol. 73, Issue. 2, p. 305.


    Liang, Peifeng Zu, Jian Yin, Juan Li, Hao Gao, Longfei Cui, Fuqiang Wang, Fuzhen Liang, Xiaofeng and Zhuang, Guihua 2015. The independent impact of newborn hepatitis B vaccination on reducing HBV prevalence in China, 1992–2006: A mathematical model analysis. Journal of Theoretical Biology, Vol. 386, p. 115.


    Zou, Lan Ruan, Shigui and Zhang, Weinian 2015. On the sexual transmission dynamics of hepatitis B virus in China. Journal of Theoretical Biology, Vol. 369, p. 1.


    Miller, Mark A. and Hinman, Alan R. 2013. Vaccines.


    van Rijckevorsel, Gini Whelan, Jane Kretzschmar, Mirjam Siedenburg, Evelien Sonder, Gerard Geskus, Ronald Coutinho, Roel and van den Hoek, Anneke 2013. Targeted vaccination programme successful in reducing acute hepatitis B in men having sex with men in Amsterdam, The Netherlands. Journal of Hepatology, Vol. 59, Issue. 6, p. 1177.


    Xiridou, Maria van Houdt, Robin Hahné, Susan Coutinho, Roel van Steenbergen, Jim and Kretzschmar, Mirjam 2013. Hepatitis B vaccination of men who have sex with men in the Netherlands: should we vaccinate more men, younger men or high-risk men?. Sexually Transmitted Infections, Vol. 89, Issue. 8, p. 666.


    Zhou, Xichuan Li, Qin Zhu, Zhenglin Zhao, Han Tang, Hao and Feng, Yujie 2013. Monitoring Epidemic Alert Levels by Analyzing Internet Search Volume. IEEE Transactions on Biomedical Engineering, Vol. 60, Issue. 2, p. 446.


    Mann, Joanne and Roberts, Mick 2011. Modelling the epidemiology of hepatitis B in New Zealand. Journal of Theoretical Biology, Vol. 269, Issue. 1, p. 266.


    Khlangwiset, P. and Wu, F. 2010. Costs and efficacy of public health interventions to reduce aflatoxin-induced human disease. Food Additives & Contaminants: Part A, Vol. 27, Issue. 7, p. 998.


    Liu, Yan and Wu, Felicia 2010. Global Burden of Aflatoxin-Induced Hepatocellular Carcinoma: A Risk Assessment. Environmental Health Perspectives, Vol. 118, Issue. 6, p. 818.


    Medley, Graham F. and Nokes, D. James 2010. Topley & Wilson's Microbiology and Microbial Infections.


    Zou, Lan Zhang, Weinian and Ruan, Shigui 2010. Modeling the transmission dynamics and control of hepatitis B virus in China. Journal of Theoretical Biology, Vol. 262, Issue. 2, p. 330.


    Zou, Lan Ruan, Shigui and Zhang, Weinian 2010. An Age-Structured Model for the Transmission Dynamics of Hepatitis B. SIAM Journal on Applied Mathematics, Vol. 70, Issue. 8, p. 3121.


    Kretzschmar, Mirjam Mangen, Marie-Josee van de Laar, Marita and de Wit, Ardine 2009. Model based analysis of hepatitis B vaccination strategies in the Netherlands. Vaccine, Vol. 27, Issue. 8, p. 1254.


    Akmatov, Manas K. Kretzschmar, Mirjam Krämer, Alexander and Mikolajczyk, Rafael T. 2008. Timeliness of vaccination and its effects on fraction of vaccinated population. Vaccine, Vol. 26, Issue. 31, p. 3805.


    Sutton, A.J. Gay, N.J. and Edmunds, W.J. 2006. Modelling the impact of prison vaccination on hepatitis B transmission within the injecting drug user population of England and Wales. Vaccine, Vol. 24, Issue. 13, p. 2377.


    Williams, John R. 2006. Handbook of Models for Human Aging.


    Zuckerman, Jane and Langer, Barbara 2005. Hepatitis B vaccination in a school age population: a feasibility study. Journal of Medical Virology, Vol. 76, Issue. 1, p. 47.


    Hughes, James P. Garnett, Geoff P. and Koutsky, Laura 2002. The Theoretical Population-Level Impact of a Prophylactic Human Papilloma Virus Vaccine. Epidemiology, Vol. 13, Issue. 6, p. 631.


    CUNNINGHAM, ANTHONY L. MINDEL, ADRIAN and DWYER, DOMINIC E. 2000. Sexually Transmitted Diseases.


    ×

The transmission dynamics of hepatitis B in the UK: a mathematical model for evaluating costs and effectiveness of immunization programmes

  • J. R. Williams (a1), D. J. Nokes (a1), G. F. Medley (a2) and R. M. Anderson (a1)
  • DOI: http://dx.doi.org/10.1017/S0950268800058970
  • Published online: 01 May 2009
Abstract
Summary

Complex hepatitis B (HBV) epidemiology makes it difficult to evaluate and compare effectiveness of different immunization policies. A method for doing so is presented using a mathematical model of HBV transmission dynamics which can represent universal infant and adolescent vaccination strategies and those targeted at genito-urinary (GU) clinic attenders and infants born to infectious mothers. Model structure, epidemiological underpinning, and parameterization, are described. Data from the UK National Survey of Sexual Attitudes and Lifestyles is used to define patterns of sexual activity and GU clinic attendance; data deficiencies are discussed, in particular that of UK seroprevalence of HBV markers stratified by age, sex, and risk factors. General model predictions of endemic HBV marker prevalence in homosexual and heterosexual populations seem consistent with published UK data. The simulations exhibit non-linearities in the impact of different vaccination strategies. Estimated number of carriers prevented per vaccine dose for each strategy provides a measure of costs and benefits, varying temporally over the course of a programme, and with level of vaccine coverage. Screening before vaccination markedly increases payback per dose in homosexuals but not in heterosexuals; mass infant vaccination gives the poorest effectiveness ratio and vaccination of infants after antenatal screening the best; in general, increasing vaccine coverage yields lower pay-back per dose. The model provides a useful framework for evaluating costs and benefits of immunization programmes, but for precise quantitative comparison more UK epidemiological data is urgently needed.

Copyright
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1.S Sherlock . Hepatitis B: the disease. Vaccine 1990; 8 (Suppl.): 69.

2.WJ Edmund , GF Medley , DJ Nokes , AJ Hall , HC Whittle . The influence of age on the development of the hepatitis B carrier state. Proc R Soc Lond B 1993; 253: 197201.

4.A Derso , EH Boxall , MJ Tarlow , TH Flewett . Transmission of HBsAg from mother to infant in four ethnic groups. BMJ 1978; 1: 949–52.

7.Y Ghendon . WHO strategy for the global elimination of new cases of hepatitis B. Vaccine 1990; 8 (Suppl.): 129–33.

10.BS Bloom , AL Hillman , AM Fendrick , JS Schwartz . A reappraisal of Hepatitis B virus vaccination strategies using cost-effectiveness analysis. Ann Intern Med 1993; 118: 298306.

11.DA Asch . Cost and effectiveness of hepatitis B immunization. Ann Intern Med 1993; 119: 536–7.

12.RM Anderson , RM May . Infectious diseases of humans: dynamics and control. Oxford: Oxford University Press, 1991.

16.JE Banatvala , IL Chrystie , SJ Palmer , A Kenny . Retrospective study of HIV, hepatitis B, and HTLV-1 infection at a London antenatal clinic. Lancet 1990; 335: 859–60.

17.N Bhatti , RJC Gilson , M Beecham , Failure to deliver hepatitis B vaccine: confessions from a genitourinary medicine clinic. BMJ 1991; 303: 97101.

18.GJ Hart , J Dawson , RM Fitzpatrick , Risk behaviour, anti-HIV and anti-hepatitis B core prevalence in clinic and non-clinic samples of gay men in England. 1991–1992. AIDS 1993; 7: 863–9.

19.JC Coleman , BA Evans , A Thornton , AJ Zuckerman . Homosexual hepatitis. J Infect 1979; 1: 61–6.

21.BA Evans , SM McCormack , RA Bond , KD MacRae , RW Thorp . Human immunodeficiency virus infection, hepatitis B virus infection, and sexual behaviour of women attending a genitourinary medicine clinic. BMJ 1988; 296: 473–5.

22.KS Lim , RD Catterall , R Simon , DS Dane , M Briggs , RS Tedder . A reservoir of hepatitis B. J Infect 1979; 1: 163–70.

23.JAJ Barbara , DR Howell , TE Cleghorn , CH Cameron , M Briggs , DS Dane . A comparison of different methods of screening blood donations for HBsAg. Vox Sanguinis 1977; 32: 49.

26.HM Smith , GJM Alexander , G Webb , T McManus , IG McFarlane , R Williams . Hepatitis B and delta virus infection among [at risk] populations in south east London. J Epidemiol Commun Hlth 1992; 46: 144–7.

27.AD Kitchen , TJ Harrison , TJ Meacock , AJ Zuckerman , JF Harrison . Incidence and significance of hepatitis B core antibody in a healthy donor population. J Med Virol 1988; 25: 6975.

28.AG Redeker , JW Mosley , DJ Gocke , AP McKee , W Pollack . Hepatitis B immune globulin as a prophylactic measure for spouses exposed to acute type B hepatitis. New Eng J Med 1975; 293: 1055–9.

29.WLM Alward , BJ McMahon , DB Hall , WL Heyward , DP Francis , TP Bender . The long term serological course of asymptomatic hepatitis B virus carriers and the development of primary hepatocellular carcinoma. J Infect Dis 1985; 151: 604–9.

31.JR Williams , RM Anderson . Mathematical models of the transmission dynamics of human immunodeficiency virus in England and Wales: mixing between different risk groups. J R Statist Soc A 1994; 157: 6987.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×