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Trends in encephalitis-associated deaths in the United States

  • N. KHETSURIANI (a1), R. C. HOLMAN (a2), A. C. LAMONTE-FOWLKES (a1), R. M. SELIK (a3) and L. J. ANDERSON (a1)...

The United States national mortality statistics and HIV/AIDS surveillance data were analysed to determine trends in encephalitis-associated deaths and to assess the impact of HIV infection on those deaths during 1979–1998, a period when ICD-9 codes were used for coding deaths in the United States. A total of 25 125 encephalitis deaths were reported; 4779 of them (19%) had concurrent HIV infection. Overall encephalitis death rates remained stable, but they increased for groups where HIV infection was common and declined or remained unchanged for others. For persons without HIV infection, the rates declined in all demographic groups. Encephalitis deaths in HIV-infected persons followed general trends for HIV deaths in the United States. The rates in the HIV-infected population were several hundred- to thousand-fold higher than in the HIV-uninfected population. HIV infection was largely responsible for the lack of overall decline in the considerable mortality associated with encephalitis in the United States during 1979–1998.

Corresponding author
*Author for correspondence: N. Khetsuriani, M.D., Ph.D., Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS-A34, Atlanta, GA 30333, USA. (Email:
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3.  CA Glaser , . In search of encephalitis etiologies: diagnostic challenges in the California Encephalitis Project, 1998–2000. Clinical Infectious Diseases 2003; 36: 731742.

5.  H Kolski , . Etiology of childhood encephalitis at the Hospital for Sick Children, Toronto, 1994–1995. Clinical Infectious Diseases 1998; 26: 398409.

6.  N Khetsuriani , RC Holman , LJ Anderson . Burden of encephalitis-associated hospitalizations in the United States, 1988–1997. Clinical Infectious Diseases 2002; 35: 175182.

7.  GL Armstrong , LA Conn , RW Pinner . Trends in infectious disease mortality in the United States during the 20th century. Journal of the American Medical Association 1999; 281: 6166.

15.  RM Selik , RH Byers Jr., MS Dworkin . Trends in diseases reported on U.S. death certificates that mentioned HIV infection, 1987–1999. Journal of Acquired Immune Deficiency Syndrome 2002; 29: 278287.

19.  RJ Whitley , JW Gnann . Viral encephalitis: familiar infections and emerging pathogens. Lancet 2002; 359: 507513.

20.  RJ Whitley , F Lakeman . Herpes simplex virus infections of the central nervous system: therapeutic and diagnostic considerations. Clinical Infectious Diseases 1995; 20: 414420.

21.  LR Petersen , AA Marfin , DJ Gubler . West Nile Virus. Journal of the American Medical Association 2003; 290: 524528.

22.  KB Chua , . Nipah virus: a recently emergent deadly paramyxovirus. Science 2000; 288: 14321435.

23.  JJ Yan , . An outbreak of enterovirus 71 infection in Taiwan 1998: a comprehensive pathological, virological, and molecular study on a case of fulminant encephalitis. Journal of Clinical Virology 2000; 17: 1322.

27.  LE Barker , ET Luman . Changes in vaccination coverage estimates among children aged 19–35 months in the United States, 1996–1999. American Journal of Preventive Medicine 2001; 20 (4 Suppl.): 2831.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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