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The UK Register of HIV Seroconverters: methods and analytical issues

Published online by Cambridge University Press:  15 May 2009

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A Register of HIV-infected persons who have had a negative antibody test within 3 years of their first antibody positive test (seroconverters) is being set up in the UK to monitor the distribution of times from HIV seroconversion to AIDS (the incubation period) and to death. It will also provide a national resource for use by those designing studies in this group of individuals. Clinicians caring for HIV-positive persons in Genito-Urinary Medicine, Infectious Disease and other departments throughout the UK were asked to participate by providing information on eligible subjects. Most laboratories undertaking HIV antibody testing were also contacted and asked to provide the name of the attending clinician for all seroconverters identified through the HIV laboratory reporting systems of the PHLS Communicable Disease Surveillance Centre (CDSC) and the Scottish Centre for Infection and Environmental Health (SCIEH) and for any other seroconverters known to them but not identified by CDSC or SCIEH. Data items sought for the Register include: sex, ethnic group, probable route of HIV transmission, annual CD4 counts, details of therapy and prophylaxis prescribed, AIDS-defining events and vital status. Follow up information is collected annually. Wherever possible, all seroconverters known to a clinic have been identified, whether currently alive or dead, either from clinic records or laboratory reporting or both. The objective is to establish and update a complete register of seroconverters on a long-term basis to provide reliable estimates of the incubation period on which future projections of AIDS cases in the UK can be made.

Information

Type
Research Article
Information
Epidemiology & Infection , Volume 117 , Issue 2 , October 1996 , pp. 305 - 312
Copyright
Copyright © Cambridge University Press 1996

References

1.Hessol, NA, Koblin, BA, van Griensven, GJP, et al. Progression of human immunodeficiency virus type 1 (HIV-1) infection among homosexual men in hepatitis B vaccine trial cohorts in Amsterdam, New York City, and San Francisco, 1978–1991. Am J Epidemiol 1994;139: 1077–87.Google Scholar
2.Muñoz, A, Schrager, LK, Bacellar, H, et al. Trends in the incidence of outcomes defining acquired immunodeficiency syndrome (AIDS) in the Multicentre AIDS Cohort Study: 1985–1991. Am J Epidemiol 1993: 137: 423–38.CrossRefGoogle Scholar
3.Learmont, J, Tindall, B, Evans, L, et al. Long-term symptomless HIV-1 infection in recipients of blood products from a single donor. Lancet 1992; 340: 863–7.Google Scholar
4.Ward, JW, Bush, TJ, Perkins, HA, et al. The natural history of transfusion-associated infection with human immunodeficiency virus. New Engl J Med 1989; 321: 947–52.CrossRefGoogle ScholarPubMed
5.Rosenberg, PS, Goedert, JJ, Biggar, RJ, et al. Effect of age at seroconversion on the natural AIDS incubation distribution. AIDS 1994; 8: 803–10.Google Scholar
6.Saah, AJ, Muñoz, A, Kuo, V, et al. Predictors of the risk of development of Acquired Immunodeficiency Syndrome within 24 months among gay men seropositive for human immunodeficiency virus type I: a report from the Multicenter AIDS Cohort Study. Am J Epidemiol 1992; 135: 1147–55.Google Scholar
7.Margolick, JB, Muñoz, A, Vlahov, D, et al. Changes in T-lymphocyte subsets in intravenous drug users with HIV-l infection. JAMA 1992; 267: 1631–6.CrossRefGoogle Scholar
8.Lang, W, Perkins, H, Anderson, RE, et al. Patterns of T lymphocyte changes with human immunodeficiency virus infection: from seroconversion to the development of AIDS. J Acq Immun Defic Synd 1989; 2: 63–9.Google Scholar
9.Hessol, NA, Lifson, AR, O'Malley, PM, et al. Prevalence, incidence and progression of human immunodeficiency virus infection in homosexual and bisexual men in hepatitis B vaccine trials, 1978–1988. Am J Epidemiol 1989; 130: 1167–75.CrossRefGoogle ScholarPubMed
10.Gorham, ED, Garland, FC, Mayers, DL, et al. CD4 lymphocyte counts within 24 months of human immunodeficiency virus seroconversion. Arch Intern Med 1993; 153: 869–76.Google Scholar
11.Schechter, MT, Boyko, WJ, Craib, KJP, et al. Effects of long-term seropositivity to human immunodeficiency virus in a cohort of homosexual men. AIDS 1987; 1: 77–82.Google Scholar
12.Burcham, J, Marmor, M, Dubin, N, et al. CD4% is the best predictor of development of AIDS in a cohort of HIV-infected homosexual men. AIDS 1991; 5: 365–72.CrossRefGoogle Scholar
13.Keet, IPM, Krijnen, P, Koot, M, et al. Predictors of rapid progression to AIDS in HIV-1 seroconverters. AIDS 1993; 7: 51–7.CrossRefGoogle ScholarPubMed
14.Blaxhult, A, Granath, F, Lidman, K, Giesecke, J.. The influence of age on the latency period to AIDS in people infected by HIV through blood transfusion. AIDS 1990; 4: 125–9.Google Scholar
15.Pedersen, C, Lindhart, BØ, Jensen, BL, et al. Clinical course of primary infection: consequences for subsequent course of infection. BMJ 1989; 299: 154–7.CrossRefGoogle ScholarPubMed
16.Darby, SC, Rizza, CR, Doll, R, et al. Incidence of AIDS and excess of mortality associated with HIV in haemophiliacs in the United Kingdom: report on behalf of the directors of haemophilia centres in the United Kingdom. BMJ 1989; 298: 1064–8.CrossRefGoogle Scholar
17.Phillips, AN, Sabin, CA, Elford, J, et al. Use of CD4 lymphocyte count to predict long term survival free of AIDS after HIV infection. BMJ 1994; 309: 309–13.Google Scholar
18.Brettle, RP, McNeil, AJ, Gore, SM, et al. The Edinburgh City Hospital cohort analysis of enrolment, progression and mortality by baseline covariates. QJM 1995: 88 (7): 479–91.Google ScholarPubMed
19.Msellati, P, Dupon, M, Morlat, P et al. A cohort of 89 HIV-l infected adult patients contaminated by blood products: Bordeaux 1981–1989. AIDS 1990; 4: 1105–9.Google Scholar
20.Chiarotti, F, Palombi, M, Schinaia, N, et al. Median time from seroconversion to AIDS in Italian HIV-positive haemophiliacs: different parametric estimates. Stat Med 1994; 13: 163–75.CrossRefGoogle ScholarPubMed
21.Lepri, AC, Pezzotti, P. Dorrucci, M, et al. HIV disease progression in 854 women and men infected through injecting drug use and heterosexual sex and followed for up to nine years from seroconversion. Br Med J 1994; 309: 1537–42.Google Scholar
22.Veugelers, PJ, Page, KA, Tindall, B, et al. Determinants of HIV disease progression among homosexual men registered in the tricontinental seroconverter study. Am J Epidemiol 1994; 140: 747–58.Google Scholar
23.Ancelle-Park, RA.. European AIDS definition. Lancet 1992; 339: 671.CrossRefGoogle Scholar
24. Report of an expert group (Chairman, Professor NE Day) convened by the Director of the Public Health Laboratory Service on behalf of the Chief Medical Officers. The incidence and prevalence of AIDS and prevalence of other severe HIV disease in England and Wales for 1995–1999: projections using data to the end of 1994. CDR 1996; 6.Google Scholar
25. Report of a Working Group convened by the Chief Medical Officer for Scotland December 1995. AIDS and severe HIV-related disease in Scotland. Predictions to the end of 1999. ANSWER, 29 December 1995.Google Scholar
26.AIDS and HIV-l infection in the United Kingdom: monthly report. CDR, 1996; 6: 25–8.Google Scholar
27.Hendriks, JCM, Medley, GF, van Griensven, GJP, et al. The treatment-free incubation period of AIDS in a cohort of homosexual men. AIDS 1993; 7: 231–9.Google Scholar
28.Kuo, J-M, Taylor, JMG, Detels, R.. Estimating the AIDS incubation period from a prevalent cohort. Am J Epidemiol 1991; 133: 1050–7.Google Scholar