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The use of saliva for viral diagnosis and screening.

  • Philip P. Mortimer (a1) and John V. Parry (a1)

Extract

The strength and diversity of antibody responses to infection are the basis for many of the most rapid and sensitive tests in virology, yet the need to obtain the patient's consent and co–operation, to collect blood from a vein and to separate the serum before the test often deters investigators, particularly if children are involved or if there is added risk, difficulty or cost in doing the venepuncture.

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References

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Brown, D. W. G. (1986). Viral diagnosis by antibody capture assay. In Public Health Virology–12 Reports (ed. Mortimer, P. P.), pp. 92108.
Cohen, B. J., Mortimer, P. P. & Pereira, M. S. (1983). Diagnostic assays with monoclonal antibodies for the human serum parvovirus–like virus (SPLV). Journal of Hygiene (London) 91. 113130.
Duermeyer, W., Wieland, F. & Van Der, Veen J. (1979). A new principle for the detection of specific IgM antibodies as applied in an ELISA for hepatitis A. Journal of Medical Virology 4. 2532.
Flehmig, B., Ranke, M., Berthold, H. & Gerth, H. J. (1979). A solid phase radio–immunoassay for detection of IgM antibodies to hepatitis A virus. Journal of Infectious Diseases 140. 169175.
Golub, L. M. & Kleinberg, I. (1976). Gingival crevicular fluid: A new diagnostic aid in managing the periodontal patient. Oral Sciences Reviews (ed. Melcher, A.H.Zarib, G. A.), pp. 4961.
Henle, G. & Henle, W. (1986). Epstein–Barr virus–specific IgA serum antibodies as an outstanding feature of nasopharyngeal carcinoma. International Journal of Cancer 17, 17.
Jenkins, G. N. (1978). The Physiology and Biochemistry of the Mouth, 4th ed., pp. 324327. Blackwell Scientific publications, Oxford.
Lehner, T. (1982). Immunological Aspects of Oral Disease: Clinical Aspects of Immunology, 4th ed. (ed. Lachman, and Peters, ), pp. 939943. Oxford: Blackwell Scientific Publications.
Murray, P. A., Greive, W. G. & Winkler, J. R. (1987). The humoral immune response in HIV associated periodontitis Abstract (THP 142) presented at IIIrd International Conference on AIDS.
Parry, J. V. (1986). An immunoglobulin G capture assay (GACRIA) for anti–HTLV III/LAV and its use as a confirmatory test. Journal of Medical Virology 19, 387397.
Parry, J. V., Perry, K. R. & Mortimer, P. P. (1987). Sensitive assays for viral antibodies in saliva: an alternative to tests on serum. Lancet 7275.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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