Article contents
Vaccination of man with attentuated live adenovirus
Published online by Cambridge University Press: 15 May 2009
Extract
Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Eighteen volunteers were given live adenovirus attenuated by passage in pig kidney tissue culture. Thirteen were given adenovirus Type 7 and five were given adenovirus Type 4. All volunteers who were given Type 7 and who had no homologous neutralizing antibody on inoculation showed antibody rises. Except in one volunteer not in isolation no signficant symptoms were seen.
It is suggested that adenoviruses attenuated in this way might be useful for large-scale vaccination programmes.
- Type
- Research Article
- Information
- Copyright
- Copyright © Cambridge University Press 1960
References
Bell, J. A., Ward, T. G., Huesbner, R. J., Rowe, W. P., Susind, R. G. & Paffenbarger, R. S. Jr, (1956). Amer. J. publ. Hlth, 46, 1130.CrossRefGoogle Scholar
Culver, J. O., Lennette, E. H., Flintjer, J. D., Stevens, T. E. & Fox, V. L. (1959) (ii). Amer. J. Hyg. 69, 112.Google Scholar
Culver, J. O., Lennette, E. H., Fox, V. L. & Flintjer, J. D. (1959) (i). Amer. J. Hyg. 69, 38.Google Scholar
Gundelfinger, B. F., Hantover, M. J., Bell, J. A., Loosli, C. G. & Rowe, W. P. (1958). Amer. J. Hyg. 68, 156.Google Scholar
Hilleman, M. R., Stallones, R. A., Gauld, R. L., Warfield, M. S. & Anderson, S. A. (1956). Proc. Soc. exp. Biol., N.Y., 92, 377.CrossRefGoogle Scholar
Hilleman, M. R., Warfield, M. S., Anderson, S. A. & Werner, J. H. (1957) (i). J. Amer. med. Ass. 163, 4.CrossRefGoogle Scholar
Hilleman, M. R., Flatley, F. J., Anderson, S. A., Luecking, M. L. & Levinson, D. J. (1958) (ii). J. Immunol. 80, 299.CrossRefGoogle Scholar
Hilleman, M. R., Greenberg, J. H., Warfield, M. S., Anderson, S. A. & Glabere, R. R. (1958). Amer. Med. Ass. Arch. Int. Med. 102, 428.CrossRefGoogle Scholar
Huebner, R. J., Bell, J. A., Rowe, W. P., Ward, T. G., Suskind, R. G. & Hartley, J. W. (1955). J. Amer. med. Ass. 159, 986.CrossRefGoogle Scholar
Stallones, R. A., Hilleman, M. R., Gauld, R. L., Warfield, M. S. & Anderson, S. A. (1957). J. Amer. med. Ass. 163, 9.CrossRefGoogle Scholar
You have
Access
- 17
- Cited by