Skip to main content
×
×
Home

The association between the serotonin and dopamine neurotransmitters and personality traits

  • G. Delvecchio (a1), M. Bellani (a2), A. C. Altamura (a3) and P. Brambilla (a3) (a4)
Abstract

Evidence from previous studies has reported that complex traits, including psychiatric disorders, are moderately to highly heritable. Moreover, it has also been shown that specific personality traits may increase the risk to develop mental illnesses. Therefore the focus of the research shifted towards the identification of the biological mechanisms underpinning these traits by exploring the effects of a constellation of genetic polymorphisms in healthy subjects. Indeed, studying the effect of genetic variants in normal personality provides a unique means for identifying candidate genes which may increase the risk for psychiatric disorders. In this review, we discuss the impact of two of the most frequently studied genetic polymorphisms on personality in healthy subjects, the 5-HTT polymorphism of the serotonin transporter and the DRD2/DRD4 polymorphisms of the D2/D4 dopamine's receptors. The main aims are: (a) to highlight that the study of candidate genes provides a fruitful ground for the identification of the biological underpinnings of personality without, though, reaching a general consensus about the strength of this relationship; and (b) to outline that the research in personality genetics should be expanded to provide a clearer picture of the heritability of personality traits.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      The association between the serotonin and dopamine neurotransmitters and personality traits
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      The association between the serotonin and dopamine neurotransmitters and personality traits
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      The association between the serotonin and dopamine neurotransmitters and personality traits
      Available formats
      ×
Copyright
Corresponding author
*Address for correspondence: Dr M. Bellani, Department of Public Health and Community Medicine, University of Verona, Piazzale L.A. Scuro 10, 37134 Verona, Italy; Professor P. Brambilla, Department of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, via F. Sforza 35, 20122 Milan, Italy. (Email: marcella.bellani@univr.it; paolo.brambilla1@unimi.it)
Footnotes
Hide All

This Section of Epidemiology and Psychiatric Sciences appears in each issue of the Journal to stress the relevance of epidemiology for behavioral neurosciences, reporting the results of studies that explore the use of an epidemiological approach to provide a better understanding of the neural basis of major psychiatric disorders and, in turn, the utilisation of the behavioural neurosciences for promoting innovative epidemiological research.

The ultimate aim is to help the translation of most relevant research findings into every-day clinical practice. These contributions are written in house by the journal's editorial team or commissioned by the Section Editor (no more than 1000 words, short unstructured abstract, 4 key-words, one Table or Figure and up to ten references).

Paolo Brambilla, Section Editor

Footnotes
References
Hide All
Al-Halabí, S, Herrero, R, Sáiz, PA, García-Portilla, MP, Errasti, JM, Corcoran, (2011). A cross-cultural comparison between Spain and the USA: temperament and character distribution by sex and age. Psychiatry Research 186, 397401.
Benjamin, J, Li, L, Patterson, C, Greenberg, BD, Murphy, DL, Hamer, DH (1996). Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking. Nature Genetics 12, 8184.
Brambilla, P, Fagnani, C, Cecchetto, F, Medda, E, Bellani, M, Salemi, M, Picardi, A, Stazi, MA (2014). Genetic and environmental bases of the interplay between magical ideation and personality. Psychiatry Research 215, 453459.
Brändström, S, Richter, J, Przybeck, T (2001). Distributions by age and sex of the dimensions of Temperament and Character Inventory in a crosscultural perspective among Sweden, Germany, and the USA. Psychological Reports 89, 747758.
Calati, R, Signorelli, MS, Gressier, F, Bianchini, O, Porcelli, S, Comings, DE, De Girolamo, G, Aguglia, E, MacMurray, J, Serretti, A (2014). Modulation of a number of genes on personality traits in a sample of healthy subjects. Neuroscience Letters 566, 320325.
Cloninger, CR, Przybeck, TR, Svrakic, DM, Wetzel, RD (1994). The Temperament and Character Inventory (TCI): a Guide to its Development and Use. Center for Psychobiology of Personality, Washington University: St. Louis, MO.
Comings, D, Gade-Andavolu, R, Gonzalez, N, Wu, S, Muhleman, D, Blake, H (2000). A multi-variate analysis of 59 candidate genes in personality traits: the temperament and character inventory. Clinical Genetics 58, 375385.
Ebstein, RP, Novick, O, Umansky, R, Priel, B, Osher, Y, Blaine, D (1996). Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking. Nature Genetics 12, 7880.
Fresán, A, Robles-García, R, López-Avila, A, Cloninger, CR (2011). Personality differences according to age and sex in a Mexican sample using the Temperament and Character Inventory-Revised. Comprehensive Psychiatry 52, 774779.
Gebhardt, C, Leisch, F, Schüssler, P, Fuchs, K, Stompe, T, Sieghart, W, Hornik, K, Kasper, S, Aschauer, HN (2004). Non-association of dopamine D4 and D2 receptor genes with personality in healthy individuals. American Journal of Medical Genetics Part B, Neuropsychiatric Genetics 126B, 106110.
Gonda, X, Fountoulakis, KN, Juhasz, G, Rihmer, Z, Lazary, J, Laszik, A, Akiskal, HS, Bagdy, G (2009). Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population. European Archives of Psychiatry and Clinical Neuroscience 259, 106113.
Ham, BJ, Kim, YH, Choi, MJ, Cha, JH, Choi, YK, Lee, MS (2004). Serotonergic genes and personality traits in the Korean population. Neuroscience Letters 354, 25.
Herbst, JH, Zonderman, AB, McCrae, RR, Costa, PT (2000). Do the dimensions of the temperament and character inventory map a simple genetic architecture? Evidence from molecular genetics and factor analysis. American Journal of Psychiatry 157, 12851290.
Kuzelova, H, Ptacek, R, Macek, M (2010). The serotonin transporter gene (5-HTT) variant and psychiatric disorders: review of current literature. Neuroendocrinology Letters 31, 410.
Lee, HJ, Lee, HS, Kim, YK, Kim, L, Lee, MS, Jung, IK, Suh, KY, Kim, S (2003). D2 and D4 dopamine receptor gene polymorphisms and personality traits in a young Korean population. American Journal of Medical Genetics Part B, Neuropsychiatric Genetics 121B, 4449.
Lesch, K-P, Bengel, D, Heils, A, Sabol, SZ, Greenberg, BD, Petri, S (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274, 15271531.
Missale, C, Nash, SR, Robinson, SW, Jaber, M, Caron, MG (1998). Dopamine receptors: from structure to function. Physiological Review 78, 189225.
Mohr, C, Ettinger, U (2014). An overview of the association between schizotypy and dopamine. Frontiers in Psychiatry 5, 184.
Noble, EP, Ozkaragoz, TZ, Ritchie, TL, Zhang, X, Belin, TR, Sparkes, RS (1998). D2 and D4 dopamine receptor polymorphisms and personality. American Journal of Medical Genetics: Neuropsychiatric Genetics 81, 257267.
Ono, Y, Manki, H, Yoshimura, K, Muramatsu, T, Mizushima, H, Higuchi, S, Yagi, G, Kanba, S, Asai, M (1997). Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects. American Journal of Medical Genetics 74, 501503.
Pełka-Wysiecka, J, Ziętek, J, Grzywacz, A, Kucharska-Mazur, J, Bienkowski, P, Samochowiec, J (2012). Association of genetic polymorphisms with personality profile in individuals without psychiatric disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry 39, 4046.
Picardi, A, Fagnani, C, Medda, E, Toccaceli, V, Brambilla, P, Stazi, MA (2015). Genetic and environmental influences underlying the relationship between autistic traits and temperament and character dimensions in adulthood. Comprehensive Psychiatry 58, 178188.
Plomin, R, Deary, IJ (2015). Genetics and intelligence differences: five special findings. Molecular Psychiatry 20, 98108.
Saiz, PA, Garcia-Portilla, MP, Herrero, R, Arango, C, Corcoran, P, Morales, B, Bascarán, MT, Alvarez, V, Coto, E, Paredes, B, Fernández, JM, Bobes, J (2010). Interactions between functional serotonergic polymorphisms and demographic factors influence personality traits in healthy Spanish Caucasians. Psychiatry Genetics 20, 171178.
Tsuchimine, S, Yasui-Furukori, N, Sasaki, K, Kaneda, A, Sugawara, N, Yoshida, S, Kaneko, S (2012). Association between the dopamine D2 receptor (DRD2) polymorphism and the personality traits of healthy Japanese participants. Progress in Neuro-Psychopharmacology and Biological Psychiatry 38, 190193.
Van Gestel, S, Van Broeckhoven, C (2003). Genetics of personality: are we making progress? Molecular Psychiatry 8, 840852.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology and Psychiatric Sciences
  • ISSN: 2045-7960
  • EISSN: 2045-7979
  • URL: /core/journals/epidemiology-and-psychiatric-sciences
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 99
Total number of PDF views: 359 *
Loading metrics...

Abstract views

Total abstract views: 724 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 19th August 2018. This data will be updated every 24 hours.