Hostname: page-component-848d4c4894-nmvwc Total loading time: 0 Render date: 2024-06-20T10:33:15.919Z Has data issue: false hasContentIssue false

Human Papillomavirus in the Aetiology and Prevention of Genital Cancers

Published online by Cambridge University Press:  09 February 2016

Abstract

In the first part of this paper the molecular epidemiological evidence linking HPV to cervical cancer and other genital cancers is reviewed based mainly on the research work of the author. In the second part, the implications of the epidemiological findings for the prevention of cervical cancer are discussed in two areas: in primary prevention by the use of prophylactic HPV vaccines and in secondary prevention by increasing the accuracy of cervical cancer screening.

Type
Erasmus Lecture 2014
Copyright
© Academia Europaea 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Globocan (2012) http://www.globocan.iarc.fr (accessed June 2014).Google Scholar
2.Muñoz, N. (2009) From causality to prevention – the example of cervical cancer: my personal contribution to this fascinating history. Public Health Genomics, 12, pp. 368371.CrossRefGoogle ScholarPubMed
3.Muñoz, N., Bosch, F. X., de Sanjosé, S., Navarro, C., Moreo, P., Ascunce, N.et al. (1992) The causal link between human papillomavirus and invasive cervical cancer: a population-based case-control study in Colombia and Spa. International Journal of Cancer, 52(5), pp. 743749.CrossRefGoogle Scholar
4.Muñoz, N., Bosch, F. X., de Sanjosé, S., Herrero, R., Castellsagué, X., Shah, K. V.et al. (2003) Epidemiologic classification of human papillomavirus types associated with cervical cancer. New England Journal of Medicine, 348(6), 518527.CrossRefGoogle ScholarPubMed
5.Bouvard, V., Baan, R., Straif, K., Grosse, Y., Secretan, B., El Ghissassi, F.et al. (2009) A review of human carcinogens-part B: biological agents. Lancet Oncology, 10(4), pp. 321322.CrossRefGoogle ScholarPubMed
6.Muñoz, N., Castellsagué, X., de Gonzalez, A. B. and Gismann, L. (2006) Chapter 1: HPV in the etiology of human cancer. Vaccine, 24(3), pp. 110.CrossRefGoogle ScholarPubMed
7.Walboomers, J. M. M., Jacobs, M. V., Manos, M. M., Bosch, F. X., Kummer, J. A., Shah, K. V.et al. (1999) Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. Journal of Pathology, 189(1), pp. 1219.3.0.CO;2-F>CrossRefGoogle ScholarPubMed
8.de Sanjosé, S., Quint, W. G., Alemany, L., Geraets, D. T., Klaustermeier, J. E., Lloveras, B.et al. (2010) Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study. Lancet Oncology, 11(11), pp. 10481056.CrossRefGoogle ScholarPubMed
9.Muñoz, N., Kjaer, S. K., Sigurdsson, K., Iversen, O. E., Hernandez-Avila, M., Wheeler, C. M.et al. (2010) Impact of human papillomavirus (HPV)-6/11/16/18 vaccine on all HPV-associated genital diseases in young women. Journal of National Cancer Institute, 102(5), pp. 325339.CrossRefGoogle Scholar
10.Palefsky, J. M., Giuliano, A. R., Goldstone, S., Moreira, E. D. Jr, Aranda, C., Jessen, H., Hillman, R.et al. (2011) HPV vaccine against anal HPV infection and anal intraepithelial neoplasia. New England Journal of Medicine, 365(17), 15761585.CrossRefGoogle ScholarPubMed
11.Schiller, J. T., Castellsagué, X. and Garland, S. M. (2012) A review of clinical trials of human papillomavirus prophylactic vaccines. Vaccine, 30(Suppl 5), pp. F123F138.CrossRefGoogle ScholarPubMed
12.Human papillomavirus vaccines: WHO position paper, October 2014, 89, pp. 465-492.Google Scholar
13.Muñoz, N., Franco, E. L., Herrero, R., Andrus, J. K., de Quadros, C. A. and Bosch, F. X. (2008) Recommendations for cervical cancer prevention in Latin America and the Caribbean. Vaccine, 26(11), pp. L96L107.CrossRefGoogle ScholarPubMed