Novel insights into molecular mechanisms of abruption-induced preterm birth

Catalin S. Buhimschi; Frederik Schatz; Graciela Krikun; Irina A. Buhimschi; Charles J. Lockwood

doi:10.1017/S1462399410001675

Novel insights into molecular mechanisms of abruption-induced preterm birth

Published online by Cambridge University Press: 01 November 2010

Catalin S. Buhimschi ,

Frederik Schatz ,

Graciela Krikun ,

Irina A. Buhimschi and

Charles J. Lockwood

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Catalin S. Buhimschi*: Affiliation:
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.
Frederik Schatz: Affiliation:
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.
Graciela Krikun: Affiliation:
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.
Irina A. Buhimschi: Affiliation:
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.
Charles J. Lockwood: Affiliation:
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.
*: *Corresponding author: Catalin S. Buhimschi, Yale University School of Medicine, Department of Obstetrics, Gynecology & Reproductive Sciences, 333 Cedar Street, LLCI 804, New Haven, CT 06520, USA. E-mail: catalin.buhimschi@yale.edu

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Abstract

Preterm birth (PTB) complicates more than 12% of all deliveries. Despite significant research, the aetiology of most cases of PTB remains elusive. Two major antecedents of PTB, intra-amniotic infection and decidual haemorrhage (abruption), can exhibit dissimilar demographic and genetic predispositions, despite sharing common molecular and cellular pathways. The use of high-throughput, high-dimensional technologies reveals substantial crosstalk between the coagulation and inflammation pathways. Tissue factor, thrombin and cytokines are key mediators of this crosstalk. Abruptions are associated with excess thrombin generated from decidual-cell-expressed tissue factor. Although thrombin is a primary mediator of the coagulation cascade, it can also promote inflammation-associated PTB by enhancing expression of matrix metalloproteinase and neutrophil-chemoattracting and -activating chemokines. Here, we provide novel insights into the molecular mechanisms and pathways leading to PTB in the setting of placental abruption.

Type: Review Article
Information: Expert Reviews in Molecular Medicine , Volume 12 , January 2010 , e35

DOI: https://doi.org/10.1017/S1462399410001675 [Opens in a new window]
Copyright: Copyright © Cambridge University Press 2010

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Novel insights into molecular mechanisms of abruption-induced preterm birth

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