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    Bazin, Dominique Jouanneau, Chantal Bertazzo, Sergio Sandt, Christophe Dessombz, Arnaud Réfrégiers, Matthieu Dumas, Paul Frederick, Joni Haymann, Jean-Philippe Letavernier, Emmanuel Ronco, Pierre and Daudon, Michel 2015. Combining field effect scanning electron microscopy, deep UV fluorescence, Raman, classical and synchrotron radiation Fourier transform Infra-Red Spectroscopy in the study of crystal-containing kidney biopsies. Comptes Rendus Chimie,

    Jiménez-Gallo, D. Ossorio-García, L. and Linares-Barrios, M. 2015. Calcinosis cutis y calcifilaxis. Actas Dermo-Sifiliográficas, Vol. 106, Issue. 10, p. 785.

    Jiménez-Gallo, D. Ossorio-García, L. and Linares-Barrios, M. 2015. Calcinosis Cutis and Calciphylaxis. Actas Dermo-Sifiliográficas (English Edition), Vol. 106, Issue. 10, p. 785.

  • Expert Reviews in Molecular Medicine, Volume 16
  • 2014, e6

Biochemical and molecular aspects of spectral diagnosis in calcinosis cutis

  • Shan-Yang Lin (a1)
  • DOI:
  • Published online: 11 March 2014

Calcinosis cutis (CC) is a type of calcinosis wherein insoluble compounds or salts deposited on the skin. Clinical diagnosis of CC is usually achieved through time consuming histopathological or immunohistochemical procedures, but it can only be empirically identified by experienced practitioners. The use of advanced vibrational spectroscopy has been recently shown to have great potential as a diagnostic technique for various diseased tissues because it analyses the chemical composition of diseased tissue rather than its anatomy and predicts disease progression. This review article includes a summary of the application of Fourier transform infrared (FT-IR) and Raman spectroscopic or microspectroscopic analysis for the rapid diagnosis and identification of the chemical composition of skin calcified deposits in patients with various CC symptoms. Both advanced techniques not only can detect the types of insoluble salts such as calcium phosphate, calcium carbonate, and monosodium urate, and β-carotene in the calcified deposits of human skin tissue but also can directly differentiate the carbonate substitution in the apatite structure of the skin calcified deposits. In particular, the combination of both vibrational techniques may provide complementary information to simultaneously assess the intact components of the calcified deposits. In the future, both FT-IR and Raman vibrational microspectroscopic techniques will become available tools to support the standard test techniques currently used in some clinical diagnoses. Molecular spectroscopy technique is rapidly changing disease diagnosis and management.

Corresponding author
Corresponding author: Prof. Shan-Yang Lin, PhD., Lab. Pharm. Biopharm., Department of Biotechnology and Pharmaceutical Technology, Yuanpei University, Hsin Chu, Taiwan, Republic of China. + 886-3-610-2439; + 886-3-610-2328; E-mail:
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