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Differentiation of mesenchymal stem cells to osteoblasts and chondrocytes: a focus on adenosine receptors

  • Shannon H. Carroll (a1) and Katya Ravid (a2) (a3) (a4)
Abstract

Skeletogenesis, either during development, post-injury or for maintenance, is a carefully coordinated process reliant on the appropriate differentiation of mesenchymal stem cells. Some well described, as well as a new regulator of this process (adenosine receptors), are alike in that they signal via cyclic-AMP (cAMP). This review highlights the known contribution of cAMP signalling to mesenchymal stem cell differentiation to osteoblasts and to chondrocytes. Focus has been given to how these regulators influence the commitment of the osteochondroprogenitor to these separate lineages.

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Corresponding author
*Corresponding author: Katya Ravid, Boston University School of Medicine, 700 Albany St Room W602, Boston, MA 02191, USA. E-mail: kravid@bu.edu
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1 B.R. Olsen , A.M. Reginato and W. Wang (2000) Annual Review of Cell and Developmental Biology 16, 191-220

2 C. Hartmann (2009) Current Opinion in Genetics & Development 19, 437-443

3 A. Schindeler (2008) Seminars in Cell & Developmental Biology 19, 459-466

4 D. Baldridge (2010) Annual Review of Genomics and Human Genetics 11, 189-217

5 A.M. DeLise , L. Fischer and R.S. Tuan (2000) Osteoarthritis and Cartilage 8, 309-334

6 B.K. Hall and T. Miyake (2000) Bioessays 22, 138-147

7 H. Enomoto (2000) Journal of Biological Chemistry 275, 8695-8702

8 T.P. Hill (2005) Developmental Cell 8, 727-738

9 T.F. Day (2005) Developmental Cell 8, 739-750

10 H. Hu (2005) Development 132, 49-60

11 J.W. Foster (1994) Nature 372, 525-530

12 T. Wagner (1994) Cell 79, 1111-1120

13 A. Augello and C. De Bari (2010) Human Gene Therapy 21, 1226-1238

14 N. Smith (2005) Journal of Cellular Physiology 203, 133-143

15 G. Zhou (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 19004-19009

16 A. Cheng and P.G. Genever (2010) Journal of Bone and Mineral Research 25, 2680-2689

17 C.J. Lengner (2005) Journal of Biological Chemistry 280, 15872-15879

18 F. Otto (1997) Cell 89, 765-771

19 T. Komori (1997) Cell 89, 755-764

20 P. Bialek (2004) Developmental Cell 6, 423-435

22 M.H. Lee (2005) Journal of Biological Chemistry 280, 35579-35587

23 R.F. Robledo (2002) Genes & Development 16, 1089-1101

24 T. Komori (2006) Journal of Cellular Biochemistry 99, 1233-1239

25 J. Han (2007) Mechanisms of Development 124, 729-745

26 G.L. Lin and K.D. Hankenson (2011) Journal of Cellular Biochemistry 112, 3491-3501

27 F. Milat and K.W. Ng (2009) Molecular and Cellular Endocrinology 310, 52-62

28 Y.F. Dong (2006) Journal of Cellular Physiology 208, 77-86

29 L. Topol (2009) Journal of Biological Chemistry 284, 3323-3333

30 J. Chen and F. Long (2012) Journal of Bone and Mineral Research doi: [10.1002/jbmr.1834] [epub ahead of print]

31 W.A. Sands and T.M. Palmer (2008) Cellular Signalling 20, 460-466

32 B. Mayr and M. Montminy (2001) Nature Reviews. Molecular Cell Biology 2, 599-609

33 K.A. Lee and N. Masson (1993) Biochimica et Biophysica Acta 1174, 221-233

35 L.C. Wilson and C.M. Hall (2002) Seminars in Musculoskeletal Radiology 6, 273-283

36 M. Riminucci (2010) Journal of Molecular Endocrinology 45, 355-364

37 E.C. Hsiao (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 1209-1214

38 A. Sakamoto (2005) Journal of Biological Chemistry 280, 21369-21375

39 J.Y. Wu (2011) Journal of Clinical Investigation 121, 3492-3504

40 N.S. Datta and A.B. Abou-Samra (2009) Cellular Signalling 21, 1245-1254

41 A.B. Abou-Samra (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 2732-2736

42 B. Lanske (1996) Science 273, 663-666

43 R.L. Jilka (2007) Bone 40, 1434-1446

44 Y. Fei and M.M. Hurley (2012) Journal of Cellular Physiology 227, 3539-3545

45 B. Yu (2012) Journal of Bone and Mineral Research 27, 2001-2014

46 H. Takase (2009) Hormone and Metabolic Research 41, 861-865

47 Y. Nakao (2009) Bone 44, 872-877

48 G.K. Chan (2003) Endocrinology 144, 5511-5520

49 A. Hollnagel , M. Ahrens and G. Gross (1997) Journal of Bone and Mineral Research 12, 1993-2004

50 A. Vortkamp (1996) Science 273, 613-622

51 C. Ghayor (2009) Biochemical and Biophysical Research Communications 381, 247-252

52 R. Siddappa (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 7281-7286

53 K.W. Lo (2012) Journal of Tissue Engineering and Regenerative Medicine 6, 40-48

54 S.H. Carroll (2012) Journal of Biological Chemistry 287, 15718-15727

55 V. Krishnan (2003) Molecular Endocrinology 17, 423-435

56 B. Gharibi (2011) Journal of Bone and Mineral Research 26, 2112-2124

57 Z.S. Xiao (2001) Journal of Cellular Biochemistry 82, 647-659

58 N. Selvamurugan (2000) Journal of Biological Chemistry 275, 5037-5042

59 N. Selvamurugan (2009) FEBS Letters 583, 1141-1146

60 K. Nakashima (2002) Cell 108, 17-29

61 Y. Nishio (2006) Gene 372, 62-70

62 B.L. Wang (2006) Journal of Endocrinological Investigation 29, 101-108

63 S.H. Hong (2009) Journal of Molecular Endocrinology 43, 197-207

64 Y. Han (2011) Biochemical and Biophysical Research Communications 407, 461-465

65 D.C. Yang (2008) PLoS One 3, e1540

66 A.J. Koh (1999) Endocrinology 140, 3154-3162

67 Y. Tintut (1999) Journal of Biological Chemistry 274, 28875-28879

68 K. Turksen (1990) Journal of Cellular Physiology 142, 61-69

69 Y. Kanai and P. Koopman (1999) Human Molecular Genetics 8, 691-696

70 S. Piera-Velazquez (2007) Experimental Cell Research 313, 1069-1079

71 M. Tsuda (2003) Journal of Biological Chemistry 278, 27224-27229

72 W. Huang (2000) Molecular and Cellular Biology 20, 4149-4158

73 L. Zhao , G. Li and G.Q. Zhou (2009) Journal of Bone and Mineral Research 24, 826-836

74 Y.M. Yoon (2000) Journal of Bone and Mineral Research 15, 2197-2205

76 B.B. Fredholm (2007) Cell Death and Differentiation 14, 1315-1323

77 C. St Hilaire (2009) Journal of Cellular Physiology 218, 35-44

78 G. Hasko (2009) Trends in Immunology 30, 263-270

79 M.A. Costa (2011) J Journal of Cellular Physiology 226, 1353-1366

80 M. Koolpe , D. Pearson and H.P. Benton (1999) Arthritis and Rheumatism 42, 258-267

81 S. Shimegi (1996) Calcified Tissue International 58, 109-113

82 I.R. Orriss (2006) Bone 39, 300-309

84 B. Gharibi (2012) International Journal of Obesity 36, 397-406

85 F. De Benedetti (2009) Hormone Research 72(Suppl 1), 26-29

86 P.M. Mountziaris and A.G. Mikos (2008) Tissue Engineering Part B: Reviews 14, 179-186

88 M.S. Nanes (2003) Gene 321, 1-15

89 L. Gilbert (2000) Endocrinology 141, 3956-3964

90 L. Gilbert (2002) Journal of Biological Chemistry 277, 2695-2701

91 H. Huang (2011) Cell Proliferation 44, 420-427

92 D.C. Lacey (2009) Osteoarthritis and Cartilage 17, 735-742

93 H. Kaneki (2006) Journal of Biological Chemistry 281, 4326-4333

94 L. Zhao (2011) Stem Cells 29, 1601-1610

95 X. Lu (2006) Journal of Biological Chemistry 281, 6297-6306

96 X. Lu (2011) Journal of Bone and Mineral Research 26, 209-219

97 H.L. Lee (2010) Experimental & Molecular Medicine 42, 437-445

98 S.S. Lee (2012) Biomaterials 33, 4251-4263

99 S. Murakami , V. Lefebvre and B. de Crombrugghe (2000) Journal of Biological Chemistry 275, 3687-3692

100 R. Sitcheran , P.C. Cogswell and A.S. Baldwin Jr (2003) Genes & Development 17, 2368-2373

101 S. Nakajima (2009) Cytokine 47, 91-97

102 N. Wehling (2009) Arthritis and Rheumatism 60, 801-812

103 H.A. Johnston-Cox , M. Koupenova and K. Ravid (2012) Arteriosclerosis, Thrombosis, and Vascular Biology 32, 870-878

104 D. Yang (2006) Journal of Clinical Investigation 116, 1913-1923

105 C. St Hilaire (2008) Biochemical and Biophysical Research Communications 375, 292-296

106 Y. Sun (2012) Journal of Cell Science 125, 4507-4517

107 W. He and B.N. Cronstein (2012) Purinergic Signal 8, 327-337

108 A. Mediero (2012) American Journal of Pathology 180, 775-786

110 J.Z. Ilich (2002) Journal of the American College of Nutrition 21, 536-544

111 C.M. Wetmore (2008) Osteoporosis International 19, 519-527

112 E.J. Waugh (2009) Osteoporosis International 20, 1-21

113 M.T. Hannan (2000) Journal of Bone and Mineral Research 15, 710-720

114 A.J. Conlisk and D.A. Galuska (2000) Preventive Medicine 31, 562-568

116 L.M. Barone (1993) Journal of Cellular Biochemistry 52, 171-182

117 M.S. Tassinari (1991) Journal of Bone and Mineral Research 6, 1029-1036

118 S.H. Liu (2011) Journal of Orthopaedic Research 29, 954-960

119 N.P. Riksen and G.A. Rongen (2012) Expert Review of Clinical Pharmacology 5, 199-218

120 J.D. Bauerle (2011) Journal of the American Society of Nephrology 22, 14-20

121 T. Eckle , M. Koeppen and H.K. Eltzschig (2009) Physiology (Bethesda) 24, 298-306

122 S.P. Colgan and H.K. Eltzschig (2012) Annual Review of Physiology 74, 153-175

123 P.G. Green (1991) Proceedings of the National Academy of Sciences of the United States of America 88, 4162-4165

124 B.N. Cronstein , D. Naime and E. Ostad (1993) Journal of Clinical Investigation 92, 2675-2682

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