Skip to main content
×
×
Home

Differentiation of mesenchymal stem cells to osteoblasts and chondrocytes: a focus on adenosine receptors

  • Shannon H. Carroll (a1) and Katya Ravid (a2) (a3) (a4)
Abstract

Skeletogenesis, either during development, post-injury or for maintenance, is a carefully coordinated process reliant on the appropriate differentiation of mesenchymal stem cells. Some well described, as well as a new regulator of this process (adenosine receptors), are alike in that they signal via cyclic-AMP (cAMP). This review highlights the known contribution of cAMP signalling to mesenchymal stem cell differentiation to osteoblasts and to chondrocytes. Focus has been given to how these regulators influence the commitment of the osteochondroprogenitor to these separate lineages.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Differentiation of mesenchymal stem cells to osteoblasts and chondrocytes: a focus on adenosine receptors
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Differentiation of mesenchymal stem cells to osteoblasts and chondrocytes: a focus on adenosine receptors
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Differentiation of mesenchymal stem cells to osteoblasts and chondrocytes: a focus on adenosine receptors
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Katya Ravid, Boston University School of Medicine, 700 Albany St Room W602, Boston, MA 02191, USA. E-mail: kravid@bu.edu
References
Hide All
1Olsen, B.R., Reginato, A.M. and Wang, W. (2000) Annual Review of Cell and Developmental Biology 16, 191-220
2Hartmann, C. (2009) Current Opinion in Genetics & Development 19, 437-443
3Schindeler, A. et al. (2008) Seminars in Cell & Developmental Biology 19, 459-466
4Baldridge, D. et al. (2010) Annual Review of Genomics and Human Genetics 11, 189-217
5DeLise, A.M., Fischer, L. and Tuan, R.S. (2000) Osteoarthritis and Cartilage 8, 309-334
6Hall, B.K. and Miyake, T. (2000) Bioessays 22, 138-147
7Enomoto, H. et al. (2000) Journal of Biological Chemistry 275, 8695-8702
8Hill, T.P. et al. (2005) Developmental Cell 8, 727-738
9Day, T.F. et al. (2005) Developmental Cell 8, 739-750
10Hu, H. et al. (2005) Development 132, 49-60
11Foster, J.W. et al. (1994) Nature 372, 525-530
12Wagner, T. et al. (1994) Cell 79, 1111-1120
13Augello, A. and De Bari, C. (2010) Human Gene Therapy 21, 1226-1238
14Smith, N. et al. (2005) Journal of Cellular Physiology 203, 133-143
15Zhou, G. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 19004-19009
16Cheng, A. and Genever, P.G. (2010) Journal of Bone and Mineral Research 25, 2680-2689
17Lengner, C.J. et al. (2005) Journal of Biological Chemistry 280, 15872-15879
18Otto, F. et al. (1997) Cell 89, 765-771
19Komori, T. et al. (1997) Cell 89, 755-764
20Bialek, P. et al. (2004) Developmental Cell 6, 423-435
21Kraus, P. and Lufkin, T. (2006) American Journal of Medical Genetics. Part A 140, 1366-1374
22Lee, M.H. et al. (2005) Journal of Biological Chemistry 280, 35579-35587
23Robledo, R.F. et al. (2002) Genes & Development 16, 1089-1101
24Komori, T. (2006) Journal of Cellular Biochemistry 99, 1233-1239
25Han, J. et al. (2007) Mechanisms of Development 124, 729-745
26Lin, G.L. and Hankenson, K.D. (2011) Journal of Cellular Biochemistry 112, 3491-3501
27Milat, F. and Ng, K.W. (2009) Molecular and Cellular Endocrinology 310, 52-62
28Dong, Y.F. et al. (2006) Journal of Cellular Physiology 208, 77-86
29Topol, L. et al. (2009) Journal of Biological Chemistry 284, 3323-3333
30Chen, J. and Long, F. (2012) Journal of Bone and Mineral Research doi: [10.1002/jbmr.1834] [epub ahead of print]
31Sands, W.A. and Palmer, T.M. (2008) Cellular Signalling 20, 460-466
32Mayr, B. and Montminy, M. (2001) Nature Reviews. Molecular Cell Biology 2, 599-609
33Lee, K.A. and Masson, N. (1993) Biochimica et Biophysica Acta 1174, 221-233
34Beavo, J.A. (1995) Physiological Reviews 75, 725-748
35Wilson, L.C. and Hall, C.M. (2002) Seminars in Musculoskeletal Radiology 6, 273-283
36Riminucci, M. et al. (2010) Journal of Molecular Endocrinology 45, 355-364
37Hsiao, E.C. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 1209-1214
38Sakamoto, A. et al. (2005) Journal of Biological Chemistry 280, 21369-21375
39Wu, J.Y. et al. (2011) Journal of Clinical Investigation 121, 3492-3504
40Datta, N.S. and Abou-Samra, A.B. (2009) Cellular Signalling 21, 1245-1254
41Abou-Samra, A.B. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 2732-2736
42Lanske, B. et al. (1996) Science 273, 663-666
43Jilka, R.L. (2007) Bone 40, 1434-1446
44Fei, Y. and Hurley, M.M. (2012) Journal of Cellular Physiology 227, 3539-3545
45Yu, B. et al. (2012) Journal of Bone and Mineral Research 27, 2001-2014
46Takase, H. et al. (2009) Hormone and Metabolic Research 41, 861-865
47Nakao, Y. et al. (2009) Bone 44, 872-877
48Chan, G.K. et al. (2003) Endocrinology 144, 5511-5520
49Hollnagel, A., Ahrens, M. and Gross, G. (1997) Journal of Bone and Mineral Research 12, 1993-2004
50Vortkamp, A. et al. (1996) Science 273, 613-622
51Ghayor, C. et al. (2009) Biochemical and Biophysical Research Communications 381, 247-252
52Siddappa, R. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 7281-7286
53Lo, K.W. et al. (2012) Journal of Tissue Engineering and Regenerative Medicine 6, 40-48
54Carroll, S.H. et al. (2012) Journal of Biological Chemistry 287, 15718-15727
55Krishnan, V. et al. (2003) Molecular Endocrinology 17, 423-435
56Gharibi, B. et al. (2011) Journal of Bone and Mineral Research 26, 2112-2124
57Xiao, Z.S. et al. (2001) Journal of Cellular Biochemistry 82, 647-659
58Selvamurugan, N. et al. (2000) Journal of Biological Chemistry 275, 5037-5042
59Selvamurugan, N. et al. (2009) FEBS Letters 583, 1141-1146
60Nakashima, K. et al. (2002) Cell 108, 17-29
61Nishio, Y. et al. (2006) Gene 372, 62-70
62Wang, B.L. et al. (2006) Journal of Endocrinological Investigation 29, 101-108
63Hong, S.H. et al. (2009) Journal of Molecular Endocrinology 43, 197-207
64Han, Y. et al. (2011) Biochemical and Biophysical Research Communications 407, 461-465
65Yang, D.C. et al. (2008) PLoS One 3, e1540
66Koh, A.J. et al. (1999) Endocrinology 140, 3154-3162
67Tintut, Y. et al. (1999) Journal of Biological Chemistry 274, 28875-28879
68Turksen, K. et al. (1990) Journal of Cellular Physiology 142, 61-69
69Kanai, Y. and Koopman, P. (1999) Human Molecular Genetics 8, 691-696
70Piera-Velazquez, S. et al. (2007) Experimental Cell Research 313, 1069-1079
71Tsuda, M. et al. (2003) Journal of Biological Chemistry 278, 27224-27229
72Huang, W. et al. (2000) Molecular and Cellular Biology 20, 4149-4158
73Zhao, L., Li, G. and Zhou, G.Q. (2009) Journal of Bone and Mineral Research 24, 826-836
74Yoon, Y.M. et al. (2000) Journal of Bone and Mineral Research 15, 2197-2205
75Fredholm, B.B. et al. (2001) Pharmacological Reviews 53, 527-552
76Fredholm, B.B. (2007) Cell Death and Differentiation 14, 1315-1323
77St Hilaire, C. et al. (2009) Journal of Cellular Physiology 218, 35-44
78Hasko, G. et al. (2009) Trends in Immunology 30, 263-270
79Costa, M.A. et al. (2011) J Journal of Cellular Physiology 226, 1353-1366
80Koolpe, M., Pearson, D. and Benton, H.P. (1999) Arthritis and Rheumatism 42, 258-267
81Shimegi, S. (1996) Calcified Tissue International 58, 109-113
82Orriss, I.R. et al. (2006) Bone 39, 300-309
83Takedachi, M. et al. (2011) Journal of Cellular Physiology 227, 2262-2631
84Gharibi, B. et al. (2012) International Journal of Obesity 36, 397-406
85De Benedetti, F. (2009) Hormone Research 72(Suppl 1), 26-29
86Mountziaris, P.M. and Mikos, A.G. (2008) Tissue Engineering Part B: Reviews 14, 179-186
87Blackburn, M.R. et al. (2009) Handbook of Experimental Pharmacology 195, 215-269
88Nanes, M.S. (2003) Gene 321, 1-15
89Gilbert, L. et al. (2000) Endocrinology 141, 3956-3964
90Gilbert, L. et al. (2002) Journal of Biological Chemistry 277, 2695-2701
91Huang, H. et al. (2011) Cell Proliferation 44, 420-427
92Lacey, D.C. et al. (2009) Osteoarthritis and Cartilage 17, 735-742
93Kaneki, H. et al. (2006) Journal of Biological Chemistry 281, 4326-4333
94Zhao, L. et al. (2011) Stem Cells 29, 1601-1610
95Lu, X. et al. (2006) Journal of Biological Chemistry 281, 6297-6306
96Lu, X. et al. (2011) Journal of Bone and Mineral Research 26, 209-219
97Lee, H.L. et al. (2010) Experimental & Molecular Medicine 42, 437-445
98Lee, S.S. et al. (2012) Biomaterials 33, 4251-4263
99Murakami, S., Lefebvre, V. and de Crombrugghe, B. (2000) Journal of Biological Chemistry 275, 3687-3692
100Sitcheran, R., Cogswell, P.C. and Baldwin, A.S. Jr (2003) Genes & Development 17, 2368-2373
101Nakajima, S. et al. (2009) Cytokine 47, 91-97
102Wehling, N. et al. (2009) Arthritis and Rheumatism 60, 801-812
103Johnston-Cox, H.A., Koupenova, M. and Ravid, K. (2012) Arteriosclerosis, Thrombosis, and Vascular Biology 32, 870-878
104Yang, D. et al. (2006) Journal of Clinical Investigation 116, 1913-1923
105St Hilaire, C. et al. (2008) Biochemical and Biophysical Research Communications 375, 292-296
106Sun, Y. et al. (2012) Journal of Cell Science 125, 4507-4517
107He, W. and Cronstein, B.N. (2012) Purinergic Signal 8, 327-337
108Mediero, A. et al. (2012) American Journal of Pathology 180, 775-786
109Rapuri, P.B. et al. (2001) American Journal of Clinical Nutrition 74, 694-700
110Ilich, J.Z. et al. (2002) Journal of the American College of Nutrition 21, 536-544
111Wetmore, C.M. et al. (2008) Osteoporosis International 19, 519-527
112Waugh, E.J. et al. (2009) Osteoporosis International 20, 1-21
113Hannan, M.T. et al. (2000) Journal of Bone and Mineral Research 15, 710-720
114Conlisk, A.J. and Galuska, D.A. (2000) Preventive Medicine 31, 562-568
115Kiel, D.P. et al. (1990) American Journal of Epidemiology 132, 675-684
116Barone, L.M. et al. (1993) Journal of Cellular Biochemistry 52, 171-182
117Tassinari, M.S. et al. (1991) Journal of Bone and Mineral Research 6, 1029-1036
118Liu, S.H. et al. (2011) Journal of Orthopaedic Research 29, 954-960
119Riksen, N.P. and Rongen, G.A. (2012) Expert Review of Clinical Pharmacology 5, 199-218
120Bauerle, J.D. et al. (2011) Journal of the American Society of Nephrology 22, 14-20
121Eckle, T., Koeppen, M. and Eltzschig, H.K. (2009) Physiology (Bethesda) 24, 298-306
122Colgan, S.P. and Eltzschig, H.K. (2012) Annual Review of Physiology 74, 153-175
123Green, P.G. et al. (1991) Proceedings of the National Academy of Sciences of the United States of America 88, 4162-4165
124Cronstein, B.N., Naime, D. and Ostad, E. (1993) Journal of Clinical Investigation 92, 2675-2682
125Silverman, M.H. et al. (2008) Journal of Rheumatology 35, 41-48
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Expert Reviews in Molecular Medicine
  • ISSN: -
  • EISSN: 1462-3994
  • URL: /core/journals/expert-reviews-in-molecular-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed