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Heart valve tissue engineering: how far is the bedside from the bench?

Published online by Cambridge University Press:  24 September 2015

Andres Sanz-Garcia ,
Jorge Oliver-de-la-Cruz ,
Vicente Mirabet ,
Carolina Gandía ,
Alejandro Villagrasa ,
Enrique Sodupe  and
Carmen Escobedo-Lucea
Andres Sanz-Garcia
Affiliation:
Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, P.O. Box 56, 00014 Helsinki, Finland Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawada-Cho, 162-8666 Shinjuku-Ku, Tokyo, Japan
Jorge Oliver-de-la-Cruz
Affiliation:
International Clinical Research Center, Integrated Center of Cellular Therapy and Regenerative Medicine, St. Anne's University Hospital, Brno, Czech Republic
Vicente Mirabet
Affiliation:
Cell and Tissue Bank, Regional Transfusion Center, Valencia, Spain
Carolina Gandía
Affiliation:
Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, P.O. Box 56, 00014 Helsinki, Finland
Alejandro Villagrasa
Affiliation:
Hospital Fundación Jimenez Diaz, IIS-FJD, 28040 Madrid, Spain
Enrique Sodupe
Affiliation:
EDMANS Group, University of La Rioja, C/Luis de Ulloa 20, 26004 Logrono, Spain
Carmen Escobedo-Lucea*
Affiliation:
Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, P.O. Box 56, 00014 Helsinki, Finland Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawada-Cho, 162-8666 Shinjuku-Ku, Tokyo, Japan
*
*Corresponding author:Carmen Escobedo-Lucea, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, P.O. Box 56, 00014 Helsinki, Finland. E-mail: carmen.escobedo-lucea@helsinki.fi
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Abstract

Heart disease, including valve pathologies, is the leading cause of death worldwide. Despite the progress made thanks to improving transplantation techniques, a perfect valve substitute has not yet been developed: once a diseased valve is replaced with current technologies, the newly implanted valve still needs to be changed some time in the future. This situation is particularly dramatic in the case of children and young adults, because of the necessity of valve growth during the patient's life. Our review focuses on the current status of heart valve (HV) therapy and the challenges that must be solved in the development of new approaches based on tissue engineering. Scientists and physicians have proposed tissue-engineered heart valves (TEHVs) as the most promising solution for HV replacement, especially given that they can help to avoid thrombosis, structural deterioration and xenoinfections. Lastly, TEHVs might also serve as a model for studying human valve development and pathologies.

Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 17 , 2015 , e16
Copyright
Copyright © Cambridge University Press 2015 

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